CRL3–SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling

The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation

(2019) Maria Guillamot et al.   NATURE IMMUNOLOGY

MYD88L265P Mutation in Lymphoid Malignancies

(2018) Xinfang Yu et al.   CANCER RESEARCH

OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling

(2018) Yu Zhao et al.   MOLECULAR CELL

Biomarkers for checkpoint inhibition in hematologic malignancies

(2018) Djordje Atanackovic et al.   SEMINARS IN CANCER BIOLOGY

Speckle-type POZ protein functions as a tumor suppressor in non-small cell lung cancer due to DNA methylation

(2018) Sumei Yao et al.   Cancer Cell International

Architecture of the human interactome defines protein communities and disease networks

(2017) Edward L. Huttlin et al.   NATURE

Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

(2017) Jinfang Zhang et al.   NATURE

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation

(2017) Pingzhao Zhang et al.   NATURE MEDICINE

Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors

(2017) Hana Janouskova et al.   NATURE MEDICINE

Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer

(2017) Xiaofeng Jin et al.   PLoS Genetics

Mechanisms of NF-κB deregulation in lymphoid malignancies

(2016) Daniel Krappmann et al.   SEMINARS IN CANCER BIOLOGY

Silencing speckle-type POZ protein by promoter hypermethylation decreases cell apoptosis through upregulating Hedgehog signaling pathway in colorectal cancer

(2016) Xiaofei Zhi et al.   Cell Death & Disease

Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation

(2015) Jian An et al.   MOLECULAR CELL

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression

(2015) Wenjian Gan et al.   MOLECULAR CELL

Deubiquitinase CYLD acts as a negative regulator for bacterium NTHi-induced inflammation by suppressing K63-linked ubiquitination of MyD88

(2015) Byung-Cheol Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover

(2015) P Zhang et al.   Cell Death & Disease

Activation of lymphoma-associated MyD88 mutations via allostery-induced TIR-domain oligomerization

(2014) M. Avbelj et al.   BLOOD

Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer

(2014) J.-P. P. Theurillat et al.   SCIENCE

Destruction of Full-Length Androgen Receptor by Wild-Type SPOP, but Not Prostate-Cancer-Associated Mutants

(2014) Jian An et al.   Cell Reports

Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma

(2013) Bjoern Chapuy et al.   CANCER CELL

Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes

(2012) Matthieu Le Gallo et al.   NATURE GENETICS

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

MYD88 L265P Somatic Mutation in IgM MGUS

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia

(2012) Steven P. Treon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1

(2011) C Li et al.   ONCOGENE

Oncogenically active MYD88 mutations in human lymphoma

(2010) Vu N. Ngo et al.   NATURE

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

(2009) Min Zhuang et al.   MOLECULAR CELL

The expression of 16 genes related to the cell of origin and immune response predicts survival in elderly patients with diffuse large B-cell lymphoma treated with CHOP and rituximab

(2008) J-P Jais et al.   LEUKEMIA