Speckle-type POZ protein functions as a tumor suppressor in non-small cell lung cancer due to DNA methylation

A tumor suppressor role for C/EBPα in solid tumors: more than fat and blood

(2017) A R Lourenço et al.   ONCOGENE

Decreased expression of speckle-type POZ protein for the prediction of poor prognosis in patients with non-small cell lung cancer

(2017) Jing-Jing Li et al.   Oncology Letters

Selective inhibition of EZH2 by ZLD10A blocks H3K27 methylation and kills mutant lymphoma cells proliferation

(2016) Xuejiao Song et al.   BIOMEDICINE & PHARMACOTHERAPY

C/EBPα Short-Activating RNA Suppresses Metastasis of Hepatocellular Carcinoma through Inhibiting EGFR/β-Catenin Signaling Mediated EMT

(2016) Hongbo Huan et al.   PLoS One

Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover

(2015) P Zhang et al.   Cell Death & Disease

Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts

(2015) Francesca Fasanelli et al.   Nature Communications

Down-regulation of the expression of CCAAT/enhancer binding protein α gene in cervical squamous cell carcinoma

(2014) Zemin Pan et al.   BMC CANCER

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The emerging role of speckle-type POZ protein (SPOP) in cancer development

(2014) Ram-Shankar Mani   DRUG DISCOVERY TODAY

Refining standard practice and admitting uncertainty

(2014) Stephen V. Liu et al.   Nature Reviews Clinical Oncology

Somatic mutation ofSPOPtumor suppressor gene is rare in breast, lung, liver cancers, and acute leukemias

(2013) Min Sung Kim et al.   APMIS

The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications

(2013) Pascal Genschik et al.   EMBO JOURNAL

Chromatin proteins and modifications as drug targets

(2013) Kristian Helin et al.   NATURE

Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover

(2013) C. Geng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of DNA Methylation Is Linked to Genetic Aberrations in Chronic Lymphocytic Leukemia

(2013) C. C. Oakes et al.   Cancer Discovery

Mutational and expressional analyses ofSPOP, a candidate tumor suppressor gene, in prostate, gastric and colorectal cancers

(2012) Min S. Kim et al.   APMIS

Gene silencing of SLC5A8 identified by genome-wide methylation profiling in lung cancer

(2012) Jong Y. Park et al.   LUNG CANCER

The significance of epigenetic alterations in lung carcinogenesis

(2012) Ewa Brzeziańska et al.   MOLECULAR BIOLOGY REPORTS

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

(2012) Sarah K Knutson et al.   Nature Chemical Biology

Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes

(2012) Matthieu Le Gallo et al.   NATURE GENETICS

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1

(2011) C Li et al.   ONCOGENE

Lung cancer screening

(2010) U Pastorino   BRITISH JOURNAL OF CANCER

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

Lung cancer

(2010) Arnaud Van Den Broeck et al.   Cell Adhesion & Migration

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

(2009) Min Zhuang et al.   MOLECULAR CELL

Analysis of Drosophila Segmentation Network Identifies a JNK Pathway Factor Overexpressed in Kidney Cancer

(2009) J. Liu et al.   SCIENCE

PPAR  and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale

(2008) M. I. Lefterova et al.   GENES & DEVELOPMENT

Different estrogen receptor β expression in distinct histologic subtypes of lung adenocarcinoma

(2008) Greta Alì et al.   HUMAN PATHOLOGY