STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease

cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING

(2018) Zhao Lei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

STING dependent sensing – Does HIV actually care?

(2018) Christian Krapp et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

(2018) Oliver Krenkel et al.   HEPATOLOGY

Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation

(2018) Chun-Seok Cho et al.   HEPATOLOGY

Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030

(2018) Chris Estes et al.   JOURNAL OF HEPATOLOGY

Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease

(2018) Cynthia Lebeaupin et al.   JOURNAL OF HEPATOLOGY

Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease

(2018) J.T. Qiao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice

(2018) Xianjun Luo et al.   GASTROENTEROLOGY

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

(2018) Yongsheng Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysis

(2017) Parambir S. Dulai et al.   HEPATOLOGY

Targeting hepatic macrophages to treat liver diseases

(2017) Frank Tacke   JOURNAL OF HEPATOLOGY

The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications

(2017) Anna Alisi et al.   MEDIATORS OF INFLAMMATION

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

(2016) Cynthia Ju et al.   Cellular & Molecular Immunology

Histology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in Adults and Children

(2016) David E. Kleiner et al.   Clinics in Liver Disease

Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease

(2016) Yaron Rotman et al.   GUT

Chemokine (C-C motif) receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury

(2016) Jana C. Mossanen et al.   HEPATOLOGY

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection

(2016) Martin K. Thomsen et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes

(2016) Arvin Iracheta-Vellve et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The macrophage activation marker sCD163 is associated with morphological disease stages in patients with non-alcoholic fatty liver disease

(2016) Konstantin Kazankov et al.   LIVER INTERNATIONAL

Positive feedback regulation of type I interferon by the interferon-stimulated gene STING

(2015) F. Ma et al.   EMBO REPORTS

Association of Adipose Tissue Inflammation With Histologic Severity of Nonalcoholic Fatty Liver Disease

(2015) Johannie du Plessis et al.   GASTROENTEROLOGY

The immunophenotype of antigen presenting cells of the mononuclear phagocyte system in normal human liver – A systematic review

(2015) Otto Strauss et al.   JOURNAL OF HEPATOLOGY

Arginase 2 deficiency results in spontaneous steatohepatitis: A novel link between innate immune activation and hepatic de novo lipogenesis

(2015) Laura A. Navarro et al.   JOURNAL OF HEPATOLOGY

CD163L1 and CLEC5A discriminate subsets of human resident and inflammatory macrophages in vivo

(2015) E. Gonzalez-Dominguez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis

(2014) Josef Ehling et al.   GUT

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Secretory leukocyte protease inhibitor: A pivotal mediator of anti-inflammatory responses in acetaminophen-induced acute liver failure

(2013) Charalambos Gustav Antoniades et al.   HEPATOLOGY

The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease

(2013) Victoria L. Gadd et al.   HEPATOLOGY

Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis

(2013) A. Wehr et al.   JOURNAL OF IMMUNOLOGY

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

(2013) J. Petrasek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING-dependent cytosolic DNA sensing pathways

(2013) Glen N. Barber   TRENDS IN IMMUNOLOGY

Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans

(2012) Charalambos Gustav Antoniades et al.   HEPATOLOGY

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury

(2011) Christer Baeck et al.   GUT

Circulating CD14+CD16+ monocyte levels predict tissue invasive character of cholangiocarcinoma

(2010) C. Subimerb et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE