Hydrogen-Deuterium Exchange and Hydroxyl Radical Footprinting for Mapping Hydrophobic Interactions of Human Bromodomain with a Small Molecule Inhibitor

Recognition of Human IgG1 by Fcγ Receptors: Structural Insights from Hydrogen–Deuterium Exchange and Fast Photochemical Oxidation of Proteins Coupled with Mass Spectrometry

(2019) Liuqing Shi et al.   BIOCHEMISTRY

Mass Spectrometry-Based Fast Photochemical Oxidation of Proteins (FPOP) for Higher Order Structure Characterization

(2018) Ke Sherry Li et al.   ACCOUNTS OF CHEMICAL RESEARCH

Conformational Assessment of Adnectin and Adnectin-Drug Conjugate by Hydrogen/Deuterium Exchange Mass Spectrometry

(2018) Richard Y.-C. Huang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Delineating the role of cooperativity in the design of potent PROTACs for BTK

(2018) Adelajda Zorba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The use of fast photochemical oxidation of proteins coupled with mass spectrometry in protein therapeutics discovery and development

(2018) Jing Li et al.   DRUG DISCOVERY TODAY

An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery

(2017) Glenn R. Masson et al.   Expert Opinion on Drug Discovery

Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing

(2017) Xin Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping the Binding Interface of VEGF and a Monoclonal Antibody Fab-1 Fragment with Fast Photochemical Oxidation of Proteins (FPOP) and Mass Spectrometry

(2017) Ying Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Quantitative Protein Topography Measurements by High Resolution Hydroxyl Radical Protein Footprinting Enable Accurate Molecular Model Selection

(2017) Boer Xie et al.   Scientific Reports

Conformational-Sensitive Fast Photochemical Oxidation of Proteins and Mass Spectrometry Characterize Amyloid Beta 1–42 Aggregation

(2016) Ke Sherry Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Incorporation of a Reporter Peptide in FPOP Compensates for Adventitious Scavengers and Permits Time-Dependent Measurements

(2016) Ben Niu et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

High Structural Resolution Hydroxyl Radical Protein Footprinting Reveals an Extended Robo1-Heparin Binding Interface

(2015) Zixuan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications

(2015) E. Megan Flynn et al.   STRUCTURE

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

(2014) Stuart W. J. Ember et al.   ACS Chemical Biology

Applications of Hydrogen/Deuterium Exchange MS from 2012 to 2014

(2014) Gregory F. Pirrone et al.   ANALYTICAL CHEMISTRY

HDX-MS guided drug discovery: small molecules and biopharmaceuticals

(2014) David P Marciano et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Fast Photochemical Oxidation of Proteins (FPOP) Maps the Epitope of EGFR Binding to Adnectin

(2014) Yuetian Yan et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen

(2013) Enrico Malito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry

(2013) Lenka Hernychova et al.   PROTEOMICS

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

(2012) Panagis Filippakopoulos et al.   CELL

Fast Photochemical Oxidation of Proteins and Mass Spectrometry Follow Submillisecond Protein Folding at the Amino-Acid Level

(2012) Jiawei Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fast Photochemical Oxidation of Proteins for Epitope Mapping

(2011) Lisa M. Jones et al.   ANALYTICAL CHEMISTRY

Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains

(2011) Chun-wa Chung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fast Photochemical Oxidation of Proteins for Comparing Structures of Protein−Ligand Complexes: The Calmodulin−Peptide Model System

(2010) Hao Zhang et al.   ANALYTICAL CHEMISTRY

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

(2010) Jianming Zhang et al.   NATURE

Fast Photochemical Oxidation of Protein Footprints Faster than Protein Unfolding

(2009) Brian C. Gau et al.   ANALYTICAL CHEMISTRY

Analysis of Protein Conformation and Dynamics by Hydrogen/Deuterium Exchange MS

(2009) John R. Engen   ANALYTICAL CHEMISTRY

Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method

(2008) S. Y. Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA