Review
Neurosciences
Taekyun Shin, Meejung Ahn, Jeongtae Kim, Kyungsook Jung, Changjong Moon, Moon-Doo Kim
Summary: Visual disabilities are important symptoms in central nervous system autoimmune diseases such as multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Past studies have focused on neuro-inflammatory changes in the white matter of the brain, but lesions have been found in the visual pathway and retina/optic nerves. While retina and optic nerves are immunologically privileged sites, inflammation can occur via other routes.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Chiara Tremolanti, Chiara Cavallini, Laurence Meyer, Christian Klein, Eleonora Da Pozzo, Barbara Costa, Lorenzo Germelli, Sabrina Taliani, Christine Patte-Mensah, Ayikoe-Guy Mensah-Nyagan
Summary: Research suggests that phenylindoleglyoxylamydes (PIGAs) translocator protein (TSPO) ligands may have therapeutic potential in mice with myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) that mimics primary progressive multiple sclerosis (PPMS) in humans. Treatment with PIGA1138 significantly reduced clinical symptoms and improved motor function in MOG-EAE mice, while preserving myelin and axonal integrity. PIGA1138 also inhibited immune cell infiltration, reducing inflammation, and increased anti-inflammatory cytokine levels.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Immunology
Xinyu Li, Yaojuan Chu, Rui Ma, Mengmeng Dou, Silu Li, Yifan Song, Ying Lv, Lin Zhu
Summary: Ferroptosis, a unique form of regulated cell death, may be involved in the pathogenesis of neurodegenerative disorders. This study provides evidence that ferroptosis is associated with oligodendrocyte loss and demyelination in an animal model of multiple sclerosis.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Muhammad Faraz Raghib, Evanthia Bernitsas, Masaru Tanaka
Summary: This systematic review examines the effect of antimicrobials on multiple sclerosis (MS). While animal models have shown promising results, studies in humans have been limited, with only some antibiotics and antiparasitic drugs showing improvement. Further large, multicenter, well-designed studies are needed to evaluate the effect of antimicrobials in MS.
Article
Cell Biology
Changjie Shi, Jiaxue Cha, Junyuan Gong, Shaodeng Wang, Peng Zeng, Junjiang Lian, Bowen Zhang, Qiuhong Hua, Jie Lv, Changsheng Du, Xin Xie, Ru Zhang
Summary: The coexistence of multiple sclerosis (MS) and Alzheimer's disease (AD) has been observed, and A beta, one of the supervillains of AD, may play a beneficial role in preventing the progression of MS.
Article
Medicine, Research & Experimental
Arezoo Hosseini, Tohid Gharibi, Adel Mohammadzadeh, Abbas Ebrahimi-Kalan, Farhad Jadidi-niaragh, Zohreh Babaloo, Dariush Shanehbandi, Elham Baghbani, Behzad Baradaran
Summary: Ruxolitinib ameliorated the severity of EAE by modulating the balance between Th17 cells and Tregs, reducing inflammatory markers levels and increasing levels of anti-inflammatory cytokines.
Article
Food Science & Technology
Qianye Zhang, Wei Sun, Qingpeng Wang, Xuexing Zheng, Ruiyan Zhang, Ning Zhang
Summary: This study evaluated the therapeutic potential of a ketogenic diet (KD) in experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS). The results showed that KD reduces demyelination and microglial activation, decreases pro-inflammatory cytokine production, and increases anti-inflammatory cytokine production in the spinal cord and spleen. Additionally, KD inhibits the activation of certain cells and modulates specific signaling pathways. These findings suggest that KD may be an effective strategy in the treatment of MS.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Zoology
Dan Yang, Xiao-Jing Li, De-Zhen Tu, Xiu-Li Li, Bin Wei
Summary: Viral infections, especially neurotropic virus-induced viral encephalitis, have caused major public health crises. Understanding the transmission routes of these viruses and the host immune responses is crucial for controlling the spread and improving antiviral therapy outcomes.
ZOOLOGICAL RESEARCH
(2023)
Review
Neurosciences
Rhonda R. Voskuhl, Allan MacKenzie-Graham
Summary: There are many similarities in neuropathology between MS and chronic EAE induced in C57BL/6 mice, including lesions in the spinal cord and various structures in the brain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Nutrition & Dietetics
Wei-Sheng Lin, Shan-Ju Lin, Pei-Yin Liao, Divya Suresh, Ting-Rong Hsu, Pei-Yu Wang
Summary: The ketogenic diet shows promise as a safe and potentially effective therapy for multiple sclerosis, but more research is needed to confirm its effects and mechanisms.
ADVANCES IN NUTRITION
(2022)
Article
Immunology
Yossi Nishri, Nina Fainstein, Smadar Goldfarb, David Hampton, Caterina Macrini, Edgar Meinl, Siddharthan Chandran, Tamir Ben-Hur
Summary: The study found that chronic EAE in Biozzi mice exhibits similar clinical features to progressive MS, including relapsing and progressing disease, partial closure of the blood-brain barrier, reduced tissue inflammatory activity, and the development of meningeal ectopic lymphoid tissue. Late chronic Biozzi EAE also transitions from a T cell predominant disease to a B cell predominant disease, with high serum anti-MOG reactivity, making it suitable for developing disease modifying and regenerative therapies.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Article
Immunology
Davide Cossu, Kazumasa Yokoyama, Shigeto Sato, Sachiko Noda, Tamami Sakanishi, Leonardo Antonio Sechi, Nobutaka Hattori
Summary: Research shows that PINK1 protein plays a crucial role in modulating the immune response during EAE, potentially contributing to the pathogenesis of neuroinflammatory and other associated conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Qing Wang, Yang-yang Chen, Zhi-chao Yang, Hai-jun Yuan, Yi-wei Dong, Qiang Miao, Yan-qing Li, Jing Wang, Jie-zhong Yu, Bao-guo Xiao, Cun-gen Ma
Summary: This study investigates the anti-inflammatory effect of grape seed extract (GSE) in animal and cellular models, and explores its mechanism of action. The results show that GSE inhibits the secretion of inflammatory cytokines and reduces the differentiation of Th1 and Th17 cells. Moreover, GSE improves the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) mice and inhibits spinal cord demyelination and inflammatory cell infiltration.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Immunology
Ping Li, Zengli Guo, Yisong Y. Wan
Summary: Research has shown that SKI expression plays a critical role in the differentiation of pathogenic Th17 cells, and controlling SKI expression can modulate the function of these cells and treat Th17-related diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Neurosciences
Argelia Calvillo-Robledo, Cynthia Ramirez-Farias, Fernando Valdez-Urias, Erika P. Huerta-Carreon, Andres Quintanar-Stephano
Summary: Multiple sclerosis (MS) is a chronic neurodegenerative disease that affects the central nervous system. It is associated with immune system dysfunction and the breakdown of blood-brain and spinal cord barriers. The incidence of MS is increasing globally, and current therapies have significant side effects. Animal models, such as experimental autoimmune encephalomyelitis (EAE), are important for developing new treatments. The hormone arginine vasopressin (AVP) plays a role in MS development, and a blocker of AVP receptors, conivaptan, shows potential as a therapeutic target in MS treatment.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Bruno Lomonte, Paola Rey-Suarez, Julian Fernandez, Mahmood Sasa, Davinia Pla, Nancy Vargas, Melisa Benard-Valle, Libia Sanz, Carlos Correa-Netto, Vitelbina Nunez, Alberto Alape-Giron, Alejandro Alagon, Jose Maria Gutierrez, Juan J. Calvete
Article
Pharmacology & Pharmacy
M. Madrigal, A. Alape-Giron, E. Barboza-Arguedas, W. Aguilar-Ulloa, M. Flores-Diaz
Article
Pharmacology & Pharmacy
Andres Sanchez, Alvaro Segura, Mariangela Vargas, Maria Herrera, Mauren Villalta, Ricardo Estrada, Francisco Wu, Thea Litschka-Koen, Michael Alfred Perry, Alberto Alape-Giron, Guillermo Leon
Article
Infectious Diseases
Marvin Madrigal, Davinia Pla, Libia Sanz, Elexandra Barboza, Cynthia Arroyo-Portilla, Carlos Correa-Netto, Jose Maria Gutierrez, Alberto Alape-Giron, Marietta Flores-Diaz, Juan J. Calvete
PLOS NEGLECTED TROPICAL DISEASES
(2017)
Article
Biochemistry & Molecular Biology
Patricia Urbina, M. Isabel Collado, Alicia Alonso, Felix M. Goni, Marietta Flores-Diaz, Alberto Alape-Giron, Jean-Marie Ruysschaert, Marc F. Lensink
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2011)
Article
Biotechnology & Applied Microbiology
Jordi Durban, Paula Juarez, Yamileth Angulo, Bruno Lomonte, Marietta Flores-Diaz, Alberto Alape-Giron, Mahmood Sasa, Libia Sanz, Jose M. Gutierrez, Joaquin Dopazo, Ana Conesa, Juan J. Calvete
Article
Cell Biology
Laura Monturiol-Gross, Marietta Flores-Diaz, Diana Campos-Rodriguez, Rodrigo Mora, Mariela Rodriguez-Vega, David L. Marks, Alberto Alape-Giron
CELLULAR MICROBIOLOGY
(2014)
Article
Immunology
Laura Monturiol-Gross, Marietta Flores-Diaz, Cindy Araya-Castillo, Maria-Jose Pineda-Padilla, Graeme C. Clark, Richard W. Titball, Alberto Alape-Giron
JOURNAL OF INFECTIOUS DISEASES
(2012)
Article
Biochemical Research Methods
Jose Maria Gutierrez, Libia Sanz, Marietta Flores-Diaz, Lucia Figueroa, Marvin Madrigal, Maria Herrera, Mauren Villalta, Guillermo Leon, Ricardo Estrada, Adolfo Borges, Alberto Alape-Giron, Juan J. Calvete
JOURNAL OF PROTEOME RESEARCH
(2010)
Article
Biochemical Research Methods
Julian Fernandez, Alberto Aape-Giron, Yamileth Angulo, Libia Sanz, Jose Maria Gutierrez, Juan J. Calvete, Bruno Lomonte
JOURNAL OF PROTEOME RESEARCH
(2011)
Article
Multidisciplinary Sciences
Laura Monturiol-Gross, Marietta Flores-Diaz, Maria Jose Pineda-Padilla, Ana Cristina Castro-Castro, Alberto Alape-Giron
Article
Immunology
Ana Mariel Zuniga-Pereira, Carlos Santamaria, Jose Maria Gutierrez, Alberto Alape-Giron, Marietta Flores-Diaz
INFECTION AND IMMUNITY
(2019)
Article
Clinical Neurology
Fernando Gracia, Deyanira Ramirez, Alexander Parajeles-Vindas, Alejandro Diaz, Amado Diaz de la Fe, Nicia Eunice Ramirez Sanchez, Romy Castro Escobar, Luis Alberto Garcia Valle, Roberto Weiser, Biany Santos, Awilda Candelario, Aron Benzadon, Pahola Araujo, Carlos Valderrama, Mario Larreategui, Gabriela Carrillo, Karla Gracia, Johana Vazquez-Cespedes, Priscilla Monterrey-Alvarez, Kenneth Carazo-Cespedes, Alfredo Sanabria-Castro, Gustavo Miranda-Loria, Andrea Balmaceda-Meza, Ligia Ibeth Portillo Rivera, Irma Olivera Leal, Luis Cesar Rodriguez Salinas, Arnold Thompson, Ericka Lopez Torres, Daniel Enrique Pereira, Carolina Zepeda, Cesar Abdon Lopez, Ernesto Arturo Cornejo Valse, Karla Zinica Corea Urbina, Marco Antonio Urrutia, Ivonne Van Sijtveld, Blas Armien, Victor M. Rivera
Summary: This study provides a descriptive analysis of NMOSD in Central America and the Caribbean. It involves data from 186 subjects from 25 institutions across 9 countries. The study reveals a low prevalence of NMOSD in this region, with optic neuritis-transverse myelitis being the most common manifestation. Associated autoimmune diseases were also observed.
NEUROLOGY INTERNATIONAL
(2022)