Article
Biochemistry & Molecular Biology
Rui Li, Weiheng Zhao, Chen Jin, Huihua Xiong
Summary: In this study, a series of platinum(IV) complexes with 4-amino-quinazoline as ligands were synthesized and evaluated for their anticancer activities. Among them, 17b exhibited higher cytotoxicity against lung cancer cells and lower cytotoxicity towards normal cells, suggesting it as a novel strategy to overcome resistance to platinum(II) drugs.
BIOORGANIC CHEMISTRY
(2023)
Article
Engineering, Biomedical
Kun Shang, Lingpu Zhang, Yingjie Yu, Haihua Xiao, Yajuan Gao, Liu Yang, Jia Huang, Haiqin Song, Hongbin Han
Summary: The study designed composite nanoparticles that encapsulate USP1 inhibitor and platinum (IV) prodrug using a glutathione-sensitive amphiphilic polymer. These nanoparticles can target USP1 to inhibit DNA damage repair, increase the sensitivity of tumor cells to cisplatin, and enhance the anti-cancer efficacy of cisplatin.
MATERIALS TODAY BIO
(2023)
Article
Oncology
Shinichi Tate, Kyoko Nishikimi, Ayumu Matsuoka, Satoyo Otsuka, Makio Shozu
Summary: The study evaluated the safety and efficacy of weekly paclitaxel and cisplatin chemotherapy in patients with ovarian cancer who developed carboplatin hypersensitivity reaction. The majority of patients were able to complete the treatment without hypersensitivity reactions, and the therapy was found to be well-tolerated and effective for most patients.
Article
Medicine, Research & Experimental
Tushar Date, Kaushik Kuche, Rohan Ghadi, Pradeep Kumar, Sanyog Jain
Summary: Cisplatin is an anticancer drug with challenges in drug delivery. Cisplatin(IV) prodrug formation can effectively resolve these challenges. The selection of axial ligands plays a key role in determining the therapeutic outcomes. Rational design of cisplatin(IV) derivatives can improve their stability and cellular uptake, reducing side effects and offering potential in resolving cisplatin drug delivery challenges.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Steve Harakeh, Mohammed S. Almuhayawi, Isaac O. Akefe, Saber H. Saber, Soad K. Al Jaouni, Torki Alzughaibi, Yousef Almehmadi, Soad Shaker Ali, Dhruba J. Bharali, Shaker Mousa
Summary: Pomegranate nanoparticles can effectively ameliorate cisplatin-induced nephrotoxicity without compromising its antitumor efficacy.
Article
Chemistry, Multidisciplinary
Ivana Predarska, Mohamad Saoud, Dijana Draca, Ibrahim Morgan, Teodora Komazec, Thomas Eichhorn, Ekatarina Mihajlovic, Dusko Dunderovic, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Evamarie Hey-Hawkins, Goran N. Kaluderovic
Summary: Platinum(IV) conjugates based on a cisplatin scaffold containing derivatives of caffeic and ferulic acid demonstrated higher or comparable activity with respect to cisplatin against different human breast cancer cell lines, while showing superior antiproliferative activity upon immobilization in mesoporous silica nanoparticles. Mechanistic investigations revealed that these compounds induce apoptotic cell death causing strong caspase activation in a mouse breast cancer cell line.
Article
Biochemistry & Molecular Biology
Hongliang Wang, Lin Li, Jun Ye, Wujun Dong, Xing Zhang, You Xu, Jinping Hu, Rubing Wang, Xuejun Xia, Yanfang Yang, Dujia Jin, Renyun Wang, Zhihui Song, Lili Gao, Yuling Liu
Summary: CAT3 is a novel oral anti-glioma pro-drug with potent anti-tumor effects. However, its active metabolite PF403 causes significant gastrointestinal side effects. By using a self-microemulsifying drug delivery system to modify CAT3 metabolism, the bioavailability of CAT3 can be increased while reducing the generation of PF403, leading to improved anti-glioma effects and reduced gastrointestinal side effects simultaneously.
Article
Multidisciplinary Sciences
Mohammed Qari, Steve Harakeh, Isaac O. Akefe, Saber H. Saber, Rajaa Al-Raddadi, Zakaria Y. Abd Elmageed, Turki Alamri, Nagla El-Shitany, Soad S. Ali, Mohammed S. Almuhayawi, Shaker Mousa
Summary: A novel nanoparticle encapsulating pomegranate was found to improve its bioavailability and solubility, enhancing its protective effects against cisplatin-induced testicular toxicity. The nanoparticle effectively reduced oxidative stress and inflammation in testicular tissues caused by cisplatin without compromising its antitumor activity.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Steve Harakeh, Yousef Qari, Hanaa Tashkandi, Mohammed Almuhayawi, Saber H. Saber, Emad Aljahdali, Nagla El-Shitany, Soad Shaker, Filipa Lucas, Turki Alamri, Soad Al-Jaouni, Shaker Mousa
Summary: This study evaluated the protective effects of a novel nanoparticle encapsulating thymoquinone (THY) against cisplatin (CISP)-induced nephrotoxicity. The results showed that NP THY effectively prevented kidney toxicity, improved kidney function and pathology. It also ameliorated oxidative stress conditions and reduced inflammation induced by CISP in the kidney tissue.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Chemistry, Medicinal
Bo Fang, Xue Chen, Xingui Zhou, Xindan Hu, Yan Luo, Zhigang Xu, Cheng-He Zhou, Jiang-Ping Meng, Zhong-Zhu Chen, Chunsheng Hu
Summary: This study presents platinum(IV) compounds with multiple-bond ligands, which exhibited superior activity against tumor cells, proliferation, and metastasis compared to cisplatin. Compounds 2 and 5 with meta-substituted groups showed excellent performance. Research further demonstrated that compounds 2 and 5 had appropriate reduction potential and outperformed cisplatin in cellular uptake, reactive oxygen species response, apoptosis regulation, DNA damage-related gene up-regulation, and drug-resistant cell activity. The title compounds displayed better antitumor potential and fewer side effects in vivo compared to cisplatin. Introduction of multiple-bond ligands improved absorption, overcame drug resistance, and exhibited potential for mitochondrial targeting and inhibition of tumor cell detoxification.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Shunzhe Zheng, Guanting Li, Jianbin Shi, Xinying Liu, Meng Li, Zhonggui He, Chutong Tian, Ken-ichiro Kamei
Summary: Due to the severe dose-dependent toxicity and drug resistance, platinum (Pt)-based chemotherapy has limitations. Pt(IV) prodrug nanotherapeutics have emerged as a promising approach to improve the antitumor performance of Pt drugs. This article summarizes the latest advances in Pt(IV) prodrug nano-therapeutics, including their potential for overcoming biological barriers and their synergistic effects with other therapies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
Angelico D. Aputen, Maria George Elias, Jayne Gilbert, Jennette A. Sakoff, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich-Wright
Summary: The development of new and versatile platinum(IV) complexes is a rapidly evolving research strategy for cancer drug discovery. In this study, platinum(IV) complexes conjugated with non-steroidal anti-inflammatory molecules were synthesized and showed significantly improved anti-tumor potential compared to traditional platinum(II) chemotherapy drugs. These complexes also demonstrated the ability to reduce cellular and mitochondrial activity, decrease cancer cell resistance to chemotherapy, and inhibit COX-2 enzyme, thereby reducing inflammation in cancer cells.
Review
Chemistry, Inorganic & Nuclear
Quan-Bing Chen, Ling-Yue Zhou, Ling-Xin Shi, Yang Cheng, Kui Wu, Qiong Yuan, Zhi-Jun Dong, Hua-Zhi Gu, Xian-Zheng Zhang, Tao Zou
Summary: Many cisplatin analogs have been synthesized and used clinically, but they can cause adverse reactions and drug resistance. To address these issues, researchers are focusing on Pt(IV) complexes with unique chemical structures. Loading Pt(IV) complexes into nanoparticles can enhance targeted therapy and achieve multimodal theranostics through photosensitive activity.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
David Schweer, J. Robert McCorkle, Jurgen Rohr, Oleg V. Tsodikov, Frederick Ueland, Jill Kolesar
Summary: Ovarian cancer is a highly deadly malignancy with poor outcomes in cases of platinum-based chemotherapy resistance, highlighting the importance of novel therapeutic approaches. Recent advancements in semisynthetic methods have led to mithramycin analogs with improved pharmacological properties that show potential in treating platinum-resistant ovarian cancer by inhibiting the activity of the transcription factor Sp1.
Article
Nanoscience & Nanotechnology
Xiaoqian Zhao, Guoshan Zhang, Jianlin Ke, Jianguo Wang, Hongqing Zhuo
Summary: Gastric cancer is the fourth most common cancer and the second leading cause of cancer-related deaths. Finding a suitable drug delivery system for gastric cancer chemotherapy has been of great value. Platinum-based drugs, while popular, have severe side effects that limit their use. Pt(IV) prodrugs and nanocarriers may be the future of platinum-based drugs.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Chemistry, Applied
Min-Zhao Lin, Wei-Xiong Li, Tian Hu, Huaitian Bu, Zeng-Lin Li, Tianfu Wu, Xia-Xiao Wu, Chao Sun, Yongtao Li, Gang-Biao Jiang
Summary: The study developed a novel method to remove harmful algal blooms by combining flocculation and flotation functions using self-branched chitosan and CaO2@PEG. Experimental results demonstrated the effectiveness and biocompatibility of this method, which can improve water quality and reduce total phosphorus concentrations.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Yingshi Zhao, Qinyong Song, Yuebin Lin, Feng Chu, Yanchun Wei, Sen Liu, Changjiang Pan, Li Quan, Yiqing Wang
Summary: The modification of fluorescein molecules with polycaprolactone (PCL) and subsequent assembly with PEG-PCL to form fluorescent nanoparticles (PPxF) can effectively address the issues of agglomeration-induced fluorescence quenching and photobleaching. This method improves the fluorescence properties and hydrophilic nature of traditional organic fluorescent dyes, expanding their application potential significantly.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Zuan-Tao Lin, Jianhua Gu, Huie Wang, Albon Wu, Jingying Sun, Shuo Chen, Yaxi Li, Yifei Kong, Mei X. Wu, Tianfu Wu
Summary: This study reports a dual-function polymer scaffold for monitoring cell activity and drug screening in 3D cell culture. The system quantitatively monitors cell activity through conductance changes, providing a simple and direct method for evaluating drug effects.
Article
Endocrinology & Metabolism
Min Xiao, Shoujun Bai, Jing Chen, Yaxi Li, Shu Zhang, Zhao Hu
Summary: The study showed that CDKN2B-AS1 promotes apoptosis and fibrosis in HPCs and HK-2 cells induced by high glucose through the miR-98-5p/NOTCH2 axis.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Review
Immunology
Gongjun Tan, Binila Baby, Yuqiu Zhou, Tianfu Wu
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multifactorial etiology. The current diagnostic criteria for SLE have limited sensitivity and specificity, calling for the development of more accurate tools. Emerging omics technologies have potential in discovering biomarkers for SLE, but further validation is required.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yaxi Li, Hongting Wang, Zijing Zhang, Chenling Tang, Xinjin Zhou, Chandra Mohan, Tianfu Wu
Summary: The Aurora-A -> PLK1 -> mTOR signaling axis may play a central role in the pathogenesis of lupus, and emerges as a potential therapeutic target. Inhibition of PLK1 can alleviate pathological changes and symptoms in lupus mice, suggesting it as a potential treatment approach.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Yongning Li, Zhenfei Peng, Yaxi Li, Min Xiao, Gongjun Tan, Wenlian Wang, Yu Wang, Min Fang, Shu Zhang, Chenling Tang, Bowen Yang, Tianfu Wu
Summary: The development of a novel aptamer-chip-based biosensor for ochratoxin A (OTA) detection is presented, which offers rapid, sensitive, and accurate detection capabilities with potential application in food safety testing. The system showed excellent performance in detecting OTA in rice samples and could be a promising platform for toxin detection in various food products.
Article
Clinical Neurology
Li Quan, Ines Moreno-Gonzalez, Zhigang Xie, Nazaret Gamez, Laura Vegas-Gomez, Qinyong Song, Jianhua Gu, Wenhai Lin, Ruben Gomez-Gutierrez, Tianfu Wu
Summary: This study successfully detected soluble and insoluble Aβ using a near-infrared imaging probe NB, showing great potential in the early detection of AD and the deceleration and halting of AD onset and progression.
ALZHEIMERS & DEMENTIA
(2023)
Article
Immunology
Chenling Tang, Min Fang, Gongjun Tan, Shu Zhang, Bowen Yang, Yaxi Li, Ting Zhang, Ramesh Saxena, Chandra Mohan, Tianfu Wu
Summary: The objective of this study was to discover novel circulating immune complexes (ICx) as potential biomarkers for lupus nephritis (LN). A total of 77 proteins were identified as LN-specific immunoglobulin-binding proteins, and 10 potential ICx markers were further selected using bioinformatics and single-cell RNA sequencing databases. Prolyl 3-hydroxylase 1 (P3H1), phosphatase and actin regulator 4 (PHACTR4), and regulator of G-protein signaling 12 (RGS12) ICx showed discriminative capability in distinguishing LN from healthy controls, and a biomarker panel including CD14, CD34, cystatin A, myocyte enhancer factor 2C (MEF2C), RGS12, and ubiquitin C (UBC) ICx could distinguish active LN from inactive LN.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Guang Yang, Yaxi Li, Chenling Tang, Feng Lin, Tianfu Wu, Jiming Bao
Summary: A smartphone-based application was developed in this study for the analysis of signals from protein microarrays to quantify disease biomarkers. The application, using fast data processing and fluorescence intensity quantification techniques, provides multiple user functions including reading, analyzing, calculating, and reporting. The efficacy of the application was verified through testing antigens and showed a high correlation with standard tests. This smartphone application tool shows promise for cheap, efficient, and portable on-site detection in point-of-care diagnostics.
Article
Rheumatology
Chenling Tang, Shu Zhang, Aygun Teymur, Bowen Yang, Fariz Nazir, Qi Cai, Ramesh Saxena, Nancy J. Olsen, Chandra Mohan, Tianfu Wu
Summary: New serum biomarkers, including VSIG4, have been identified as potential diagnostic and predictive tools in patients with lupus nephritis (LN). These markers were validated using multiple patient cohorts, and serum VSIG4 levels were found to be correlated with LN disease activity and renal pathology.
ARTHRITIS & RHEUMATOLOGY
(2023)
Meeting Abstract
Immunology
Tianfu Wu, Yaxi Li, Shu Zhang
JOURNAL OF IMMUNOLOGY
(2022)
Article
Chemistry, Physical
Xinlei Chen, Shiyi Chen, Xuele Lin, Jingxuan Zhou, Xingjun Gao, Yaoqi Zhen, Xiaodan Ma, Shouwen Jin, Linfang Shi, Hui Liu, Daqi Wang
Summary: Nine mixed-ligand Cd2+ complexes with different geometric structures were synthesized and characterized. The complexes exhibit various coordination modes and form both intra- and intermolecular hydrogen bonds.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Rupali Mahajan, Abhishek Sharma, Bhagyashree Patra, Lijo Mani, Parul Grover, Sandeep Kumar, Santosh Kumar Guru, Gananadhamu Samanthula, Amol G. Dikundwar, Amit Asthana
Summary: This research article provides a comprehensive characterization and toxicological assessment of a photoisomeric impurity of the antianemic drug Roxadustat. The impurity has a distinct structure compared to the drug and its formation due to light exposure is a concern. Through various experiments, including single crystal XRD, physicochemical characterization, and in vitro cytotoxicity assays, the researchers confirmed the structure of the impurity, evaluated its conversion with Roxadustat, and assessed its toxicological activity. These findings contribute to the understanding of drug stability, safety, and formulation development.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Laila S. Alqarni, Azzah M. Alghamdi, Nuha Y. Elamin, A. Rajeh
Summary: The solution casting method was used to produce a new type of nanocomposites made of chitosan, gelatin, and co-doped ZnO nanoparticles. The addition of 3.5% co-doped ZnO nanoparticles improved the physicochemical characteristics and antimicrobial effects of the nanocomposites, indicating their significant potential in food packaging and energy storage.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ruchi Gaur
Summary: The structure and intermolecular interactions of a newly synthesized bis-chalcone THXA were studied using experimental and computational methods. The importance of non-covalent interactions such as pi center dot center dot center dot pi, C-H center dot center dot center dot S, and C-H center dot center dot center dot pi was revealed.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Andrii Bazylevich, Leonid Patsenker, Sarit Aviel-Ronen, Gary Gellerman
Summary: Drug combination therapy is commonly used for treating various skin disorders, but its effectiveness is often limited. In this study, researchers synthesized conjugates of anti-pigmenting drugs and hyaluronic acid (HA) to improve treatment efficacy. These HA-drug conjugates exhibited measurable drug release profiles and demonstrated superior depigmentation effects compared to control groups in a swine model.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Xiaodan Ma, Xinlei Chen, Yaoqi Zhen, Xunjie Zheng, Chengzhe Shi, Shouwen Jin, Bin Liu, Bin Chen, Daqi Wang
Summary: Cocrystallization experiments between minoxidil and aryl acids coformers resulted in the successful formation of multi-component samples. The nature of these samples was determined using various techniques and their structural and supramolecular aspects were investigated. The outcomes revealed the importance of nonbonding contacts and different types of interactions in stabilizing and expanding the crystal structures.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Najla A. Alshaye, Magdy A. Ibrahim, Al-Shimaa Badran
Summary: The chemical behavior of 3-substituted-6,8-dimethylchromones towards phenylhydrazine was examined. Different reaction conditions produced various products, and the molecular geometries and reactivity descriptors of the compounds were also investigated. The results suggest that these compounds are suitable for nonlinear optical applications.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Hayette Alliouche, Houria Bouria, Rafik Bensegueni, Mounia Guergouri, Abdelmalek Bouraiou, Ali Belfaitah
Summary: In this paper, a combined experimental and theoretical study was conducted to synthesize and characterize new 2-quinolone-piperidine and -morpholine hybrids. The results from experiments were validated using computational calculations, and the affinity between these compounds and Acetylcholinesterase/Butyrylcholinesterase was estimated through molecular docking.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Wei-Min Chen, Juan-Juan Shao, Yi Zhang, Zhen-Dong Xue, Peng-Lai Liu, Jian-Ling Ni, Li-Zhuang Chen, Qiang Gao, Fang-Ming Wang
Summary: This study synthesized and characterized a novel Mn-based LMOF, and achieved good results in detecting heavy metal Al3+ in water, showing good stability, high selectivity and sensitivity. This provides new insights into the potential applications of Mn-based MOFs in chemical sensing.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Jun-Xia Li, Yi-Jing Lu, Ke-Ying Quan, Li-Bing Wu, Xun Feng, Wei-Zhou Wang
Summary: This study synthesized two cobalt(II) complexes and analyzed their crystal structures using single-crystal X-ray diffraction. The results showed that the crystal structures of these complexes were different, and they exhibited different crystal packing and magnetic properties.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Yang Li, Yan Zhang, Hong Xu, Min Li, Zhen Li, Zi-yu Song, Ji-shi Chen, Yan-Jun Liu, Yong Sun, Zhao Yang
Summary: This study reports the synthesis and solid-state characterization of a new pharmaceutical cocrystal, PRO-BPE, which can enhance the solubility of the highly water-insoluble prodrug probenecid. The PRO-BPE cocrystals were found to have superior water solubility compared to pure PRO. This research provides valuable insights into improving the solubility of poorly soluble drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Lucas G. B. Felicio, Bianca B. M. Vieira, Ivana S. Lula, Renata Diniz, Frank Alexis, Flavio B. Miguz, Frederico B. De Sousa
Summary: A novel spiropyran derivative was synthesized for heavy metals sensing in water. The results demonstrated that the new derivative can serve as a rapid, sensitive, and simple tool for detecting Hg2+ ions in water with high selectivity.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Junqing Meng, Jie Wang, Lijuan Wang, Chunhui Lyu, Haiyan Chen, Yingpei Lyu, Baisheng Nie
Summary: Material modification with low surface energy can achieve lower surface free energy on micro-and nano-rough structures, which is crucial for developing superhydrophobic surfaces. In this study, attapulgite (APT) was modified with alkylamine, alkylammonium salt, and stearic acid, and the interaction between low surface materials and attapulgite was explained. The results showed that the hydrophobicity of APT was significantly modified by the modifiers, and the surface free energy of the composites first decreased and then increased with increasing molecular number of low surface energy monomers.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Karan Goswami, Dipak Das, Parthasarathi Bera, Sounak Roy, Md. Motin Seikh, Prasanta Kumar Sinha, Arup Gayen
Summary: This work presents the development of a simple and highly active heterogeneous Pd catalyst for Suzuki-Miyaura carbon-carbon cross-coupling reaction. The NiPdFe-1 catalyst shows the best activity and stability among the prepared catalysts. It efficiently promotes the coupling reaction between aryl bromide and phenyl boronic acid under mild reaction conditions with high isolated yields.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ekta Pardhi, Devendra Singh Tomar, Rahul Khemchandani, Gananadhamu Samanthula, Pankaj Kumar Singh, Neelesh Kumar Mehra
Summary: The main aim of this study was to prepare a drug-drug coamorphous system to improve the physiochemical properties, solubility and stability of Apremilast and Indomethacin. Various solid-state characterization techniques were used to characterize the prepared system. Molecular level interactions were studied using molecular modeling and ATR-FTIR and 1H NMR. Solubility and dissolution studies showed the benefits of the coamorphous system. The system was found to be stable for a period of five months. Permeation study also demonstrated improved flux for both drugs compared to their crystalline forms. The coamorphous system showed anti-psoriatic and anti-melanogenic activity based on molecular docking results. Overall, the developed CAM-based supersaturated system exhibited improved physicochemical properties and physical stability.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
