Hemodynamic regulation of perivalvular endothelial gene expression prevents deep venous thrombosis

Human venous valve disease caused by mutations inFOXC2andGJC2

(2017) Oliver Lyons et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves

(2016) Boksik Cha et al.   GENES & DEVELOPMENT

GATA2 is required for lymphatic vessel valve development and maintenance

(2015) Jan Kazenwadel et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymphatic vessel development: fluid flow and valve-forming cells

(2015) Tsutomu Kume   JOURNAL OF CLINICAL INVESTIGATION

FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature

(2015) Amélie Sabine et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymph flow regulates collecting lymphatic vessel maturation in vivo

(2015) Daniel T. Sweet et al.   JOURNAL OF CLINICAL INVESTIGATION

Venous thrombosis and cancer: from mouse models to clinical trials

(2015) Y. Hisada et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Venous thrombosis

(2015) Alisa S. Wolberg et al.   Nature Reviews Disease Primers

Forkhead box C2 Promoter Variant c.-512C>T Is Associated with Increased Susceptibility to Chronic Venous Diseases

(2014) Sumi Surendran et al.   PLoS One

The contribution of immobility risk factors to the incidence of venous thrombosis in an older population

(2013) M. J. Engbers et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mechanotransduction, PROX1, and FOXC2 Cooperate to Control Connexin37 and Calcineurin during Lymphatic-Valve Formation

(2012) Amélie Sabine et al.   DEVELOPMENTAL CELL

Generation of conditional alleles forFoxc1andFoxc2in mice

(2012) Amy Sasman et al.   GENESIS

Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning

(2012) Kim-Chew Lim et al.   JOURNAL OF CLINICAL INVESTIGATION

New insights into the mechanisms of venous thrombosis

(2012) Nigel Mackman   JOURNAL OF CLINICAL INVESTIGATION

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves

(2011) R. S. Srinivasan et al.   GENES & DEVELOPMENT

The endothelial microenvironment in the venous valvular sinus: thromboresistance trends and inter-individual variation

(2011) W. E. Trotman et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice

(2011) Eleni Bazigou et al.   JOURNAL OF CLINICAL INVESTIGATION

Venous Thromboembolism

(2010) Michele G. Beckman et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse

(2010) I. Choi et al.   BLOOD

Differential regulation of human and murine P-selectin expression and function in vivo

(2010) Zhenghui Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Valves of the deep venous system: an overlooked risk factor

(2009) E. G. Brooks et al.   BLOOD

Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia

(2009) Anne Limbourg et al.   Nature Protocols

Murine Model of Hindlimb Ischemia

(2009) Hiroshi Niiyama et al.   Jove-Journal of Visualized Experiments

Del-1, an Endogenous Leukocyte-Endothelial Adhesion Inhibitor, Limits Inflammatory Cell Recruitment

(2008) E. Y. Choi et al.   SCIENCE