Expression of mitochondrial membrane–linked SAB determines severity of sex-dependent acute liver injury

Acetaminophen Responsive miR-19b Modulates SIRT1/Nrf2 Signaling Pathway in Drug-Induced Hepatotoxicity

(2019) Xing Liu et al.   TOXICOLOGICAL SCIENCES

SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress

(2018) Patricia Rada et al.   ANTIOXIDANTS & REDOX SIGNALING

Acetaminophen-induced Acute Liver Failure Is More Common and More Severe in Women

(2018) Jessica B. Rubin et al.   Clinical Gastroenterology and Hepatology

Estrogen Receptors: New Directions in the New Millennium

(2018) Sylvia C Hewitt et al.   ENDOCRINE REVIEWS

New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases

(2018) Sanda Win et al.   HEPATOLOGY

Sab concentrations indicate chemotherapeutic susceptibility in ovarian cancer cell lines

(2018) Iru Paudel et al.   BIOCHEMICAL JOURNAL

PUMA induction mediates acetaminophen‐induced necrosis and liver injury

(2018) Dongshi Chen et al.   HEPATOLOGY

Protective role of p53 in acetaminophen hepatotoxicity

(2017) Yazhen Huo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides

(2017) Mark J. Graham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sab mediates mitochondrial dysfunction involved in imatinib mesylate-induced cardiotoxicity

(2017) Tara P. Chambers et al.   TOXICOLOGY

The role of MAP2 kinases and p38 kinase in acute murine liver injury models

(2017) Jun Zhang et al.   Cell Death & Disease

Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J

(2016) Luqi Duan et al.   FOOD AND CHEMICAL TOXICOLOGY

Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury

(2016) Francisco Javier Cubero et al.   GASTROENTEROLOGY

A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease

(2016) Jagpal Singh Klair et al.   HEPATOLOGY

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src

(2016) Sanda Win et al.   HEPATOLOGY

Is severe progressive liver disease caused by alpha-1-antitrypsin deficiency more common in children or adults?

(2016) Andrew S. Chu et al.   LIVER TRANSPLANTATION

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

Inactivation of Sirt1 in mouse livers protects against endotoxemic liver injury by acetylating and activating NF-κB

(2016) Xiaolan Cui et al.   Cell Death & Disease

Sub-chronic administration of LY294002 sensitizes cervical cancer cells to chemotherapy by enhancing mitochondrial JNK signaling

(2015) Tara P. Chambers et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pathophysiological significance of c-junN-terminal kinase in acetaminophen hepatotoxicity

(2015) Kuo Du et al.   Expert Opinion on Drug Metabolism & Toxicology

Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity

(2015) Sanda Win et al.   JOURNAL OF HEPATOLOGY

Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1–p53 signaling pathways

(2015) Ying Wang et al.   TOXICOLOGY LETTERS

Sex Differences in Liver Toxicity—Do Female and Male Human Primary Hepatocytes React Differently to Toxicants In Vitro?

(2015) Milena Mennecozzi et al.   PLoS One

miR-34 and p53: New Insights into a Complex Functional Relationship

(2015) Francisco Navarro et al.   PLoS One

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

(2014) Y Shi et al.   CELL DEATH AND DIFFERENTIATION

The PPARα-FGF21 Hormone Axis Contributes to Metabolic Regulation by the Hepatic JNK Signaling Pathway

(2014) Santiago Vernia et al.   Cell Metabolism

Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase

(2014) Kuo Du et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death

(2014) S Win et al.   Cell Death & Disease

MicroRNA-34a: a potential therapeutic target in human cancer

(2014) X J Li et al.   Cell Death & Disease

The p53-Estrogen Receptor Loop in Cancer

(2013) C. Berger et al.   CURRENT MOLECULAR MEDICINE

Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis

(2013) Ju Dong Yang et al.   HEPATOLOGY

Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease

(2013) Nagy A. Youssef et al.   LIVER INTERNATIONAL

Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma

(2012) Manujendra N. Saha et al.   PLoS One

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

MicroRNA Regulation of SIRT1

(2012) Munekazu Yamakuchi   Frontiers in Physiology

Mispairing C57BL/6 Substrains of Genetically Engineered Mice and Wild-Type Controls Can Lead to Confounding Results as It Did in Studies of JNK2 in Acetaminophen and Concanavalin A Liver Injury

(2011) Mohammed Bourdi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Role of cAMP-responsive Element-binding Protein (CREB)-regulated Transcription Coactivator 3 (CRTC3) in the Initiation of Mitochondrial Biogenesis and Stress Response in Liver Cells

(2011) Tin Aung Than et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Jun N-terminal Kinase (JNK)-dependent Acute Liver Injury from Acetaminophen or Tumor Necrosis Factor (TNF) Requires Mitochondrial Sab Protein Expression in Mice

(2011) Sanda Win et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation

(2011) Jeremy W. Chambers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A selective estrogen receptor α agonist ameliorates hepatic steatosis in the male aromatase knockout mouse

(2011) Jenny D Y Chow et al.   JOURNAL OF ENDOCRINOLOGY

Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments

(2010) James H Bullard et al.   BMC BIOINFORMATICS

Silencing Glycogen Synthase Kinase-3β Inhibits Acetaminophen Hepatotoxicity and Attenuates JNK Activation and Loss of Glutamate Cysteine Ligase and Myeloid Cell Leukemia Sequence 1

(2010) Mie Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

(2010) Chieko Saito et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

JNK regulation of hepatic manifestations of the metabolic syndrome

(2010) Mark J. Czaja   TRENDS IN ENDOCRINOLOGY AND METABOLISM

JNK1-dependent PUMA Expression Contributes to Hepatocyte Lipoapoptosis

(2009) Sophie C. Cazanave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of the G Protein-Coupled Receptor 30 Impairs Glucose Tolerance, Reduces Bone Growth, Increases Blood Pressure, and Eliminates Estradiol-Stimulated Insulin Release in Female Mice

(2008) Ulrika E. A. Mårtensson et al.   ENDOCRINOLOGY

Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

(2008) Hayato Nakagawa et al.   GASTROENTEROLOGY

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute Liver Failure Including Acetaminophen Overdose

(2008) Robert J. Fontana   MEDICAL CLINICS OF NORTH AMERICA

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA