Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis

A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

(2019) Wenli Dai et al.   eLife

Multi-ethnic genome-wide association study for atrial fibrillation

(2018) Carolina Roselli et al.   NATURE GENETICS

A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart

(2018) Lavanya M Iyer et al.   NUCLEIC ACIDS RESEARCH

Biobank-driven genomic discovery yields new insight into atrial fibrillation biology

(2018) Jonas B. Nielsen et al.   NATURE GENETICS

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

(2017) Ingrid E Christophersen et al.   NATURE GENETICS

Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm

(2017) Xinan H Yang et al.   eLife

Intermolecular Interactions of Cardiac Transcription Factors NKX2.5 and TBX5

(2016) Lagnajeet Pradhan et al.   BIOCHEMISTRY

Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis

(2016) Yen-Sin Ang et al.   CELL

Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis

(2016) Luis Luna-Zurita et al.   CELL

A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels

(2016) Milena B. Furtado et al.   DIFFERENTIATION

Phospholamban Inhibition by a Single Dose of Locked Nucleic Acid Antisense Oligonucleotide Improves Cardiac Contractility in Pressure Overload-Induced Systolic Dysfunction in Mice

(2016) Hirofumi Morihara et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation

(2016) Stanley Nattel et al.   Nature Reviews Cardiology

Pitx2 modulates a Tbx5 -dependent gene regulatory network to maintain atrial rhythm

(2016) Rangarajan D. Nadadur et al.   Science Translational Medicine

Genetics of Congenital Heart Defects: The NKX2-5 Gene, a Key Player

(2016) Ill-Min Chung et al.   Genes

Phospholamban Ablation Using CRISPR/Cas9 System Improves Mortality in a Murine Heart Failure Model

(2016) Manami Kaneko et al.   PLoS One

A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia

(2015) Guan-Sheng Liu et al.   CARDIOVASCULAR RESEARCH

The Current and Future Landscape of SERCA Gene Therapy for Heart Failure: A Clinical Perspective

(2015) Carl Hayward et al.   HUMAN GENE THERAPY

Emerging Directions in the Genetics of Atrial Fibrillation

(2014) Nathan R. Tucker et al.   CIRCULATION RESEARCH

Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation

(2014) Chaitali Misra et al.   HUMAN MOLECULAR GENETICS

Atrial Fibrillation Ablation

(2014) Kunihiro Nishida et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development

(2014) Sonia Stefanovic et al.   Nature Communications

SERCA2a gene therapy in heart failure: an anti-arrhythmic positive inotrope

(2013) Markus B Sikkel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transcription factors and atrial fibrillation

(2013) S. Mahida   CARDIOVASCULAR RESEARCH

Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients With Paroxysmal Atrial Fibrillation

(2013) Niels Voigt et al.   CIRCULATION

Weighted Gene Coexpression Network Analysis of Human Left Atrial Tissue Identifies Gene Modules Associated With Atrial Fibrillation

(2013) Nicholas Tan et al.   Circulation-Cardiovascular Genetics

Prevalence and spectrum of Nkx2.5 mutations associated with idiopathic atrial fibrillation

(2013) WH Xie et al.   Clinics

A novel NKX2.5 loss-of-function mutation responsible for familial atrial fibrillation

(2013) RI-TAI HUANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

SNP rs3825214 in TBX5 Is Associated with Lone Atrial Fibrillation in Chinese Han Population

(2013) Xiaobiao Zang et al.   PLoS One

Enhanced Sarcoplasmic Reticulum Ca 2+ Leak and Increased Na + -Ca 2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation

(2012) Niels Voigt et al.   CIRCULATION

Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy

(2012) Paul A. van der Zwaag et al.   EUROPEAN JOURNAL OF HEART FAILURE

New Advances in the Genetic Basis of Atrial Fibrillation

(2012) SAAGAR MAHIDA et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

TBX5 drives Scn5a expression to regulate cardiac conduction system function

(2012) David E. Arnolds et al.   JOURNAL OF CLINICAL INVESTIGATION

New insights into the molecular basis of atrial fibrillation: mechanistic and therapeutic implications

(2011) D. Dobrev et al.   CARDIOVASCULAR RESEARCH

Human Atrial Action Potential and Ca 2+ Model

(2011) Eleonora Grandi et al.   CIRCULATION RESEARCH

GATA4 loss-of-function mutations in familial atrial fibrillation

(2011) Yi-Qing Yang et al.   CLINICA CHIMICA ACTA

Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart

(2011) A. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CaMKII-Dependent Diastolic SR Ca 2+ Leak and Elevated Diastolic Ca 2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation

(2010) Stefan Neef et al.   CIRCULATION RESEARCH

Mutations in the cardiac transcription factor GATA4 in patients with lone atrial fibrillation

(2010) Maximilian G. Posch et al.   European Journal of Medical Genetics

Several common variants modulate heart rate, PR interval and QRS duration

(2010) Hilma Holm et al.   NATURE GENETICS

Genome-wide association study of PR interval

(2010) Arne Pfeufer et al.   NATURE GENETICS

An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation

(2010) M. Nadeau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational analysis of the PITX2 and NKX2-5 genes in patients with idiopathic atrial fibrillation

(2009) Leif-Hendrik Boldt et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Generation of Functional Murine Cardiac Myocytes From Induced Pluripotent Stem Cells

(2008) Christina Mauritz et al.   CIRCULATION

A Gain-of-Function TBX5 Mutation Is Associated With Atypical Holt–Oram Syndrome and Paroxysmal Atrial Fibrillation

(2008) Alex V. Postma et al.   CIRCULATION RESEARCH

Perinatal Loss of Nkx2-5 Results in Rapid Conduction and Contraction Defects

(2008) Laura E. Briggs et al.   CIRCULATION RESEARCH

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development

(2008) Meenakshi Maitra et al.   DEVELOPMENTAL BIOLOGY

Tbx5-dependent pathway regulating diastolic function in congenital heart disease

(2008) Y. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA