Structural basis of chemokine interactions with heparan sulfate, chondroitin sulfate, and dermatan sulfate

Direct detection of lysine side chain NH3+ in protein–heparin complexes using NMR spectroscopy

(2018) Krishna Mohan Sepuru et al.   ANALYST

Glycosaminoglycan Interactions Fine-Tune Chemokine-Mediated Neutrophil Trafficking: Structural Insights and Molecular Mechanisms

(2018) Krishna Rajarathnam et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Distinct differences in structural states of conserved histidines in two related proteins: NMR studies of the chemokines CXCL1 and CXCL8 in the free form and macromolecular complexes

(2018) Krishna Mohan Sepuru et al.   BIOCHEMISTRY

Structural basis, stoichiometry, and thermodynamics of binding of the chemokines KC and MIP2 to the glycosaminoglycan heparin

(2018) Krishna Mohan Sepuru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions

(2018) Prem Raj B. Joseph et al.   Scientific Reports

How do chemokines navigate neutrophils to the target site: Dissecting the structural mechanisms and signaling pathways

(2018) Krishna Rajarathnam et al.   CELLULAR SIGNALLING

Chondroitin sulfates and their binding molecules in the central nervous system

(2017) L Djerbal et al.   GLYCOCONJUGATE JOURNAL

Glycosaminoglycan-Mediated Downstream Signaling of CXCL8 Binding to Endothelial Cells

(2017) Rupert Derler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of Regulation of the Chemokine-Receptor Network

(2017) Martin Stone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: implications for gradients and neutrophil trafficking

(2017) Prem Raj B. Joseph et al.   Open Biology

Solution structure of CXCL13 and heparan sulfate binding show that GAG binding site and cellular signalling rely on distinct domains

(2017) Yoan R. Monneau et al.   Open Biology

Platelet-Derived Chemokine CXCL7 Dimer Preferentially Exists in the Glycosaminoglycan-Bound Form: Implications for Neutrophil–Platelet Crosstalk

(2017) Aaron J. Brown et al.   Frontiers in Immunology

Shedding of Syndecan-1/CXCL1 Complexes by Matrix Metalloproteinase 7 Functions as an Epithelial Checkpoint of Neutrophil Activation

(2016) Sean E. Gill et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Molecular Basis of Chemokine CXCL5-Glycosaminoglycan Interactions

(2016) Krishna Mohan Sepuru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions

(2016) Kirti V. Sawant et al.   Scientific Reports

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

(2015) P. R. B. Joseph et al.   BIOCHEMICAL JOURNAL

Current structural biology of the heparin interactome

(2015) Vitor H Pomin et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

CXCL1/MGSA Is a Novel Glycosaminoglycan (GAG)-binding Chemokine

(2015) Krishna Mohan Sepuru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemokine CXCL1-Mediated Neutrophil Trafficking in the Lung: Role of CXCR2 Activation

(2015) Kirti V. Sawant et al.   Journal of Innate Immunity

The sweet spot: how GAGs help chemokines guide migrating cells

(2015) Yoan Monneau et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Heparan sulfate and heparin interactions with proteins

(2015) Maria C. Z. Meneghetti et al.   Journal of the Royal Society Interface

Interactions of the Chemokine CCL5/RANTES with Medium-Sized Chondroitin Sulfate Ligands

(2015) Courtney Deshauer et al.   STRUCTURE

Demystifying Heparan Sulfate–Protein Interactions

(2014) Ding Xu et al.   Annual Review of Biochemistry

CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis

(2014) Geraldine Nouailles et al.   JOURNAL OF CLINICAL INVESTIGATION

CXCL5 Drives Neutrophil Recruitment in TH17-Mediated GN

(2014) E. M. Disteldorf et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Solution Structure of CXCL5 — A Novel Chemokine and Adipokine Implicated in Inflammation and Obesity

(2014) Krishna Mohan Sepuru et al.   PLoS One

Chemokine CXCL1 Dimer Is a Potent Agonist for the CXCR2 Receptor

(2013) Aishwarya Ravindran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemokine contribution to neuropathic pain: Respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons

(2013) Zhi-Jun Zhang et al.   PAIN

Syndecan-4 Regulates Early Neutrophil Migration and Pulmonary Inflammation in Response to Lipopolysaccharide

(2012) Yoshinori Tanino et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inflammatory Chemokines Direct and Restrict Leukocyte Migration within Live Tissues as Glycan-Bound Gradients

(2012) Milka Sarris et al.   CURRENT BIOLOGY

Heparin Oligosaccharides Inhibit Chemokine (CXC Motif) Ligand 12 (CXCL12) Cardioprotection by Binding Orthogonal to the Dimerization Interface, Promoting Oligomerization, and Competing with the Chemokine (CXC Motif) Receptor 4 (CXCR4) N Terminus

(2012) Joshua J. Ziarek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice

(2012) Junjie Mei et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemokine oligomerization and interactions with receptors and glycosaminoglycans: The role of structural dynamics in function

(2011) C.L. Salanga et al.   EXPERIMENTAL CELL RESEARCH

Characterization of the interaction of interleukin-8 with hyaluronan, chondroitin sulfate, dermatan sulfate and their sulfated derivatives by spectroscopy and molecular modeling

(2011) Annelie Pichert et al.   GLYCOBIOLOGY

The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

(2011) Pavani Gangavarapu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transmembrane Signaling Proteoglycans

(2010) John R. Couchman   Annual Review of Cell and Developmental Biology

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

(2010) S. Massena et al.   BLOOD

Heparan sulfate proteoglycans in extravasation: assisting leukocyte guidance

(2010) Johanna et al.   Frontiers in Bioscience-Landmark

CXCL5 Regulates Chemokine Scavenging and Pulmonary Host Defense to Bacterial Infection

(2010) Junjie Mei et al.   IMMUNITY

NMR Analysis of the Structure, Dynamics, and Unique Oligomerization Properties of the Chemokine CCL27

(2010) Ariane L. Jansma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetics of Chemokine–Glycosaminoglycan Interactions Control Neutrophil Migration into the Airspaces of the Lungs

(2010) Yoshi Tanino et al.   JOURNAL OF IMMUNOLOGY

CXCL1 Regulates Pulmonary Host Defense to Klebsiella Infection via CXCL2, CXCL5, NF- B, and MAPKs

(2010) S. Cai et al.   JOURNAL OF IMMUNOLOGY

Structural Basis for Differential Binding of the Interleukin-8 Monomer and Dimer to the CXCR1 N-Domain: Role of Coupled Interactions and Dynamics

(2009) Aishwarya Ravindran et al.   BIOCHEMISTRY

Proteoglycans: from structural compounds to signaling molecules

(2009) Liliana Schaefer et al.   CELL AND TISSUE RESEARCH

The Structure of Glycosaminoglycans and their Interactions with Proteins

(2008) Neha S. Gandhi et al.   Chemical Biology & Drug Design

Chemokines in and out of the central nervous system: much more than chemotaxis and inflammation

(2008) Astrid E. Cardona et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The role of chemokines in neutrophil biology

(2007) Yoshiro Kobayashi   Frontiers in Bioscience-Landmark