Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3

ALK3 undergoes ligand-independent homodimerization and BMP-induced heterodimerization with ALK2

(2018) Lisa Traeger et al.   FREE RADICAL BIOLOGY AND MEDICINE

Liver iron sensing and body iron homeostasis

(2018) Chia-Yu Wang et al.   BLOOD

Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice

(2016) Susanna Canali et al.   BLOOD

Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis

(2016) Philipp-Sebastian Koch et al.   BLOOD

Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of  -thalassemia

(2015) L. Kautz et al.   BLOOD

BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism

(2014) C. Mayeur et al.   BLOOD

Identification of erythroferrone as an erythroid regulator of iron metabolism

(2014) Léon Kautz et al.   NATURE GENETICS

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

(2011) A. U. Steinbicker et al.   BLOOD

Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice

(2011) Elena Corradini et al.   HEPATOLOGY

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS