Article
Agriculture, Multidisciplinary
Yingfei Kong, Nianjie Feng, Yinggang Liang, Chen Zhou, Weiting Jiao, Jingyi Wang, Mengzhou Zhou, Qian Wu
Summary: Research shows that lotus seedpod oligomeric procyanidins (LSOPC) can effectively inhibit the absorption of oligopeptide-advanced glycation end products (OLP-AGEs) by altering their surface properties and secondary structure, weakening their affinity to transporter proteins.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Nianjie Feng, Shaowen She, Hengfeng Hu, Shimiao Tang, Jiangying Tan, Qian Wu, Juan Xiao
Summary: The study found that oligomeric procyanidins from lotus seedpod (LSOPC) could effectively delay the retrogradation process of rice starch (RS), with the inhibitory effect depending on the concentration of LSOPC. Molecular simulation revealed interactions between RS and LSOPC, highlighting the competition of hydrogen bonds as a critical factor in anti-retrogradation. This suggests potential applications of LSOPC in preventing starch retrogradation.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Qian Wu, Kuoquan Zhao, Yuanyuan Chen, Yu Ouyang, Yingna Feng, Shuyi Li, Liang Zhang, Nianjie Feng
Summary: LSOPC and CC effectively inhibit the formation of AGEs during digestion and protect Caco-2 cells; CC is more effective in inhibiting the formation of AGEs compared to LSOPC.
Article
Nutrition & Dietetics
Ziting Chen, Jiangying Tan, Jiabin Qin, Nianjie Feng, Qianting Liu, Chan Zhang, Qian Wu
Summary: LSOPC, as an additive, can significantly improve the antioxidant capacity and AGEs scavenging rate of tough biscuits, and enhance the chromatic aberration of the biscuits. Higher addition of LSOPC effectively reduces the moisture content, water activity, and pH of the tough biscuits, while improving the sensory quality of the biscuits.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Ziping Wang, Xiaolong Li, Xiaotong Ren, Siqi Zhao, Wenwen Chen, Cheng Fan, Yangliu Xu, Xuejiao Pi, Yidan Zhang, Ting Wang, Shuang Rong
Summary: This study investigated the effects of procyanidins from lotus seedpod (LSPC) on cognitive function in Alzheimer's disease (AD). The results showed that LSPC significantly improved cognitive dysfunction, reduced A beta deposition, restored CREB phosphorylation and BDNF expression, and enhanced LTP in APP/PS1 mice.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Qian Wu, Fen Zhang, Yaxiong Wang, Jia Yan, Chen Zhou, Yang Xu, Jianhua Xu, Lin Shi, He Xiong, Nianjie Feng
Summary: In this study, carboxymethyl chitosan-lotus seedpod oligomeric procyanidin nanoparticles were constructed to enhance the stability of LSOPC during digestion and inhibit the release of AGEs from G-CS. The CMC-LSOPC NPs formed cohesions to encapsulate G-CS in the gastric phase and inhibited G-CS hydrolysis. In the intestinal phase, LSOPC was released and bound to trypsin, resulting in changes in protein structure and significant reduction in trypsin activity. The CMC-LSOPC NPs also increased the antioxidant capacity of digestive fluid.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Qian Wu, Yingna Feng, Yu Ouyang, Yinggang Liang, Kuoquan Zhao, Ying Wang, Qing Luo, Juan Xiao, Nianjie Feng, Mengzhou Zhou
Summary: The study demonstrated that LSOPC inhibited AGEs formation, alleviated AGEs-induced liver injury by suppressing NF-kappa B nuclear translocation and MAPK signaling pathway activation. Additionally, LSOPC also inhibited the expression of TNF-alpha and IL-6. In conclusion, LSOPC treatment potentially modulated liver injury caused by long-term dietary AGEs by suppressing the RAGE-MAPK-NF-kappa B pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Cell Biology
Angelika Klimek, Anna Nowakowska, Hanna Kletkiewicz, Joanna Wyszkowska, Justyna Maliszewska, Milena Jankowska, Lukasz Peplowski, Justyna Rogalska
Summary: This study aimed to evaluate the effects of repeated exposure to extremely low-frequency electromagnetic field (EMF) on oxidative stress and antioxidant defense markers in the prefrontal cortex of adult rats, and to explore whether repeated EMF exposure can modify the oxidative/antioxidative status in response to other stress factors. The results showed that repeated exposure to EMF changed the oxidative/antioxidative status depending on the intensity of the EMF and the number of exposures. Weak EMF could adapt to the organism, while strong EMF exceeded the organism's adaptive capacity and increased oxidative processes when exposed to the next stress factor.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cell Biology
Dong Lin, Ruijie Qin, Lixin Guo
Summary: DR is a common complication of diabetes, with high TSH levels being associated with an increased prevalence; TSH may regulate glucose-induced PCs loss through mitochondrial apoptosis involving TSHR.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Environmental Sciences
Huixia Geng, Qihang An, Jie Song, Dongling He, Huimin Han, Lai Wang
Summary: Environmental cadmium exposure during pregnancy or adolescence can lead to neurodevelopmental toxicity and cognitive impairment. This study explored the impact of cadmium exposure on mitochondrial dynamics and apoptosis using cultured hippocampal neurons. The results showed that cadmium exposure changed mitochondrial morphology and function, increased genome methylation levels, and caused neurotoxic effects.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cen Ze-Nan, Huang Wei-Wei, Bao Jia-Li, Zheng Xiu-Xiu, Zhu Chao-Yang
Summary: The study proposed a method for real-time observation of the effects of ELF-EMFs on hippocampal neurons, finding that ROS and Ca2+ exhibited complex real-time response characteristics to ELF-EMFs, with delayed and inconsistent responses, as well as dose-dependent relationships.
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Rocio Garcia-Arroyo, Gemma Marfany, Serena Mirra
Summary: Mutations in the CERKL gene cause retinal dystrophies, but it also plays a role in regulating mitochondrial health and homeostasis in other affected tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Yunkyung Eom, Sung Rae Kim, Yeong-Kyeong Kim, Sung Hoon Lee
Summary: Mitochondria play a critical role in cellular Ca2+ homeostasis and their dysfunction has been implicated in psychological and neurological disorders. This study investigated mitochondrial Ca2+ waves in hippocampal neurons and found that they are regulated by action potentials and frequency of electrical stimulation. The results provide new insights into the mechanisms underlying mitochondrial Ca2+ buffering and the molecular basis of mitochondrial Ca2+ waves.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yanling Lin, Qinzhi Zhang, Baofu Xie, Haiyang Jiang, Jianzhong Shen, Shusheng Tang, Chongshan Dai
Summary: In this study, the cytotoxicity of Chelerythrine (CHE) was investigated using human HepG2 cells. The results showed that CHE treatment induced dose-dependent cytotoxicity and oxidative stress in HepG2 cells. Moreover, CHE treatment activated the mitochondrial apoptotic pathway and inhibited the Akt pathway, leading to cell apoptosis. N-acetylcysteine supplementation attenuated CHE-induced cytotoxicity. These findings provide new insights into the toxic mechanisms and health risks of CHE.
Article
Pharmacology & Pharmacy
Guangchan Jing, Huanyuan Wang, Fengwei Nan, Yuqin Liu, Mengren Zhang
Summary: The study demonstrated that Naofucong can inhibit neuronal injury induced by high glucose in HT22 hippocampal neurons, decrease apoptosis, IL-1 beta and IL-18 levels, and suppress NLRP1/caspase-1 mediated neuronal injury with the involvement of P2X7.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
