A Review on Bioactive Porcine Peptide, Protegrin-1

Protective Effects of Protegrin in Dextran Sodium Sulfate-Induced Murine Colitis

(2019) Evanna Huynh et al.   Frontiers in Pharmacology

Beyond electrostatics: Antimicrobial peptide selectivity and the influence of cholesterol-mediated fluidity and lipid chain length on protegrin-1 activity

(2019) J. Michael Henderson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Application of Antimicrobial Peptides of the Innate Immune System in Combination With Conventional Antibiotics—A Novel Way to Combat Antibiotic Resistance?

(2019) Maria S. Zharkova et al.   Frontiers in Cellular and Infection Microbiology

In vitro activity of Protegrin-1, alone and in combination with clinically useful antibiotics, against Acinetobacter baumannii strains isolated from surgical wounds

(2019) Gianluca Morroni et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Protegrin-1 cytotoxicity towards mammalian cells positively correlates with the magnitude of conformational changes of the unfolded form upon cell interaction

(2019) Nagasundarapandian Soundrarajan et al.   Scientific Reports

Identification of protegrin-1 as a stable and non-toxic scaffold among protegrin family- A computational approach

(2018) Shruti S. R. et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Protegrin 1 Enhances Innate Cellular Defense via the Insulin-Like Growth Factor 1 Receptor Pathway

(2018) Jenna Penney et al.   Frontiers in Cellular and Infection Microbiology

Computational prediction of the optimal oligomeric state for membrane-insertedβ-barrels of protegrin-1 and related mutants

(2017) Richard Lipkin et al.   JOURNAL OF PEPTIDE SCIENCE

Sensing lymphoma cells based on a cell-penetrating/apoptosis-inducing/electron-transfer peptide probe

(2016) Kazuharu Sugawara et al.   ANALYTICA CHIMICA ACTA

Topical delivery of low-cost protein drug candidates made in chloroplasts for biofilm disruption and uptake by oral epithelial cells

(2016) Yuan Liu et al.   BIOMATERIALS

A Thermodynamic Study of the Effects of cholesterol on the Activity of Antimicrobial Peptide Protegrin-1

(2016) Nishanth S. Iyengar et al.   BIOPHYSICAL JOURNAL

Interaction of the Antimicrobial Peptides Rhesus θ-Defensin and Porcine Protegrin-1 with Anionic Phospholipid Monolayers

(2016) Ivana Knyght et al.   LANGMUIR

Activity of Antimicrobial Peptide Protegrin-1 is Tuned by Membrane Cholesterol Content

(2015) J. Michael Henderson et al.   BIOPHYSICAL JOURNAL

Expression of porcine protegrin-1 in Pichia pastoris and its anticancer activity in vitro

(2015) MINGFU NIU et al.   Experimental and Therapeutic Medicine

Activation of human mast cells by retrocyclin and protegrin highlight their immunomodulatory and antimicrobial properties

(2015) Kshitij Gupta et al.   Oncotarget

Cholesterol Incorporation in Membranes Attenuates the Disruption Ability of Antimicrobial Peptide Protegrin-1

(2015) J. Michael Henderson et al.   BIOPHYSICAL JOURNAL

Inhibitory activity and molecular mechanism of protegrin-1 against porcine reproductive and respiratory syndrome virus in vitro

(2014) Chunhe Guo et al.   ANTIVIRAL THERAPY

Hauteigene Antibiotika

(2014) J. Cordes et al.   HAUTARZT

Membrane Interactions and Pore Formation by the Antimicrobial Peptide Protegrin

(2013) Themis Lazaridis et al.   BIOPHYSICAL JOURNAL

In Vitro Characterization of Novel Protegrin-1 Analogues Against Neoplastic Cells

(2013) Hussin A. Rothan et al.   International Journal of Peptide Research and Therapeutics

Transient expression and characterization of the antimicrobial peptide protegrin-1 in Nicotiana tabacum for control of bacterial and fungal mammalian pathogens

(2013) Omar Patiño-Rodríguez et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Membrane Disruption by Antimicrobial Peptide Protegrin-1 is Tuned by Incorporation of Cholesterol and Phosphoethanolamine Lipids

(2012) J. Michael Henderson et al.   BIOPHYSICAL JOURNAL

Multiscale Models of the Antimicrobial Peptide Protegrin-1 on Gram-Negative Bacteria Membranes

(2012) Dan S. Bolintineanu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structures of β-Hairpin Antimicrobial Protegrin Peptides in Lipopolysaccharide Membranes: Mechanism of Gram Selectivity Obtained from Solid-State Nuclear Magnetic Resonance

(2011) Yongchao Su et al.   BIOCHEMISTRY

Assessing Pore Forming Capability of Protegrin-1 in Lipid Bilayers of Varying Cholesterol Content

(2011) Eddie Maldonado et al.   BIOPHYSICAL JOURNAL

Antimicrobial Protegrin-1 Forms Amyloid-Like Fibrils with Rapid Kinetics Suggesting a Functional Link

(2011) Hyunbum Jang et al.   BIOPHYSICAL JOURNAL

Thermodynamic Analysis of Protegrin-1 Insertion and Permeation through a Lipid Bilayer

(2011) Victor Vivcharuk et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Dimerization of Protegrin-1 in Different Environments

(2010) Victor Vivcharuk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Free Energy Profile of the Interaction between a Monomer or a Dimer of Protegrin-1 in a Specific Binding Orientation and a Model Lipid Bilayer

(2010) Victor Vivcharuk et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Expression and characterization of antimicrobial peptides Retrocyclin-101 and Protegrin-1 in chloroplasts to control viral and bacterial infections

(2010) Seung-Bum Lee et al.   PLANT BIOTECHNOLOGY JOURNAL

The Origin of Antimicrobial Resistance and Fluidity Dependent Membrane Structural Transformation by Antimicrobial Peptide Protegrin-1

(2009) Matthew R. Chapman et al.   BIOPHYSICAL JOURNAL

Comparative Molecular Dynamics Simulation Studies of Protegrin-1 Monomer and Dimer in Two Different Lipid Bilayers

(2009) Huan Rui et al.   BIOPHYSICAL JOURNAL

Antimicrobial mechanism of pore-forming protegrin peptides: 100 pores to kill E. coli

(2009) Dan Bolintineanu et al.   PEPTIDES

Determining the Orientation of Protegrin-1 in DLPC Bilayers Using an Implicit Solvent-Membrane Model

(2009) Abdallah Sayyed-Ahmad et al.   PLoS One

Poisson-Nernst-Planck Models of Nonequilibrium Ion Electrodiffusion through a Protegrin Transmembrane Pore

(2009) Dan S. Bolintineanu et al.   PLoS Computational Biology

Enhanced Resistance to Bacterial Infection in Protegrin-1 Transgenic Mice

(2008) Q. C. K. Cheung et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Using Fluorous Amino Acids To Probe the Effects of Changing Hydrophobicity on the Physical and Biological Properties of the β-Hairpin Antimicrobial Peptide Protegrin-1†

(2008) Lindsey M. Gottler et al.   BIOCHEMISTRY

Models of Toxic β-Sheet Channels of Protegrin-1 Suggest a Common Subunit Organization Motif Shared with Toxic Alzheimer β-Amyloid Ion Channels

(2008) Hyunbum Jang et al.   BIOPHYSICAL JOURNAL

Pore Structure, Thinning Effect, and Lateral Diffusive Dynamics of Oriented Lipid Membranes Interacting with Antimicrobial Peptide Protegrin-1:31P and2H Solid-State NMR Study

(2008) Sungsool Wi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

On the Nature of Antimicrobial Activity:  A Model for Protegrin-1 Pores

(2008) Allison A. Langham et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protegrin interaction with lipid monolayers: grazing incidence X-ray diffraction and X-ray reflectivity study

(2008) Frances Neville et al.   Soft Matter