Glucagon Regulation of Energy Expenditure

Intranasal glucagon acutely increases energy expenditure without inducing hyperglycaemia in overweight/obese adults

(2019) Priska Stahel et al.   DIABETES OBESITY & METABOLISM

Glucagon Receptor Signaling and Lipid Metabolism

(2019) Katrine D. Galsgaard et al.   Frontiers in Physiology

The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice

(2019) Jacqueline L. Beaudry et al.   Molecular Metabolism

Repositioning Glucagon Action in the Physiology and Pharmacology of Diabetes

(2019) Brian Finan et al.   DIABETES

Glucagon-receptor Signaling Regulates Energy Metabolism Via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21

(2018) Teayoun Kim et al.   DIABETES

MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study

(2018) Philip Ambery et al.   LANCET

Does glucagon have a positive inotropic effect in the human heart?

(2018) Jesus Hernández-Cascales   Cardiovascular Diabetology

Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists

(2017) Andreas Evers et al.   JOURNAL OF MEDICINAL CHEMISTRY

Understanding the Physiology of FGF21

(2016) Ffolliott Martin Fisher et al.   Annual Review of Physiology

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

(2016) Brian Finan et al.   CELL

Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates

(2016) S. J. Henderson et al.   DIABETES OBESITY & METABOLISM

Glucagon: acute actions on hepatic metabolism

(2016) Russell A. Miller et al.   DIABETOLOGIA

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies

(2015) Christof M. Kazda et al.   DIABETES CARE

Glucagon increases energy expenditure independently of brown adipose tissue activation in humans

(2015) V. Salem et al.   DIABETES OBESITY & METABOLISM

Glucagon signalling in the dorsal vagal complex is sufficient and necessary for high-protein feeding to regulate glucose homeostasis in vivo

(2015) M. P. LaPierre et al.   EMBO REPORTS

Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice

(2015) Nicholas Douris et al.   ENDOCRINOLOGY

Effect of Oxyntomodulin, Glucagon, GLP-1, and Combined Glucagon +GLP-1 Infusion on Food Intake, Appetite, and Resting Energy Expenditure

(2015) Jonatan Ising Bagger et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Glucagon receptor antagonism induces increased cholesterol absorption

(2015) Hong-Ping Guan et al.   JOURNAL OF LIPID RESEARCH

Fibroblast growth factor-21, energy balance and obesity

(2015) Marta Giralt et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Islet α cells and glucagon—critical regulators of energy homeostasis

(2015) Jonathan E. Campbell et al.   Nature Reviews Endocrinology

FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss

(2014) Bryn M. Owen et al.   Cell Metabolism

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

Glucagon Stimulates Hepatic FGF21 Secretion through a PKA- and EPAC-Dependent Posttranscriptional Mechanism

(2014) Holly A. Cyphert et al.   PLoS One

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

(2013) K. M. Habegger et al.   DIABETES

Glucagon Regulation of Oxidative Phosphorylation Requires an Increase in Matrix Adenine Nucleotide Content through Ca2+Activation of the Mitochondrial ATP-Mg/PiCarrier SCaMC-3

(2013) Ignacio Amigo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypothalamic glucagon signaling inhibits hepatic glucose production

(2013) Patricia I Mighiu et al.   NATURE MEDICINE

Hypothalamic glucagon signals through the KATP channels to regulate glucose production

(2013) Mona A. Abraham et al.   Molecular Metabolism

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Direct Control of Brown Adipose Tissue Thermogenesis by Central Nervous System Glucagon-Like Peptide-1 Receptor Signaling

(2012) S. H. Lockie et al.   DIABETES

Coadministration of Glucagon-Like Peptide-1 During Glucagon Infusion in Humans Results in Increased Energy Expenditure and Amelioration of Hyperglycemia

(2012) T. M. Tan et al.   DIABETES

Minireview: Glucagon in Stress and Energy Homeostasis

(2012) B. J. Jones et al.   ENDOCRINOLOGY

Linagliptin Increases Incretin Levels, Lowers Glucagon, and Improves Glycemic Control in Type 2 Diabetes Mellitus

(2012) Thomas Rauch et al.   Diabetes Therapy

Physiologic action of glucagon on liver glucose metabolism

(2011) C. J. Ramnanan et al.   DIABETES OBESITY & METABOLISM

Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese mice

(2011) J. Mu et al.   DIABETOLOGIA

A guide to analysis of mouse energy metabolism

(2011) Matthias H Tschöp et al.   NATURE METHODS

Hepatic FXR: key regulator of whole-body energy metabolism

(2011) João Soeiro Teodoro et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Treatment of severe diabetic hypoglycemia with glucagon: an underutilized therapeutic approach

(2011) Kedia   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

The metabolic actions of glucagon revisited

(2010) Kirk M. Habegger et al.   Nature Reviews Endocrinology

Gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet

(2009) Margriet AB Veldhorst et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice

(2009) A. Pocai et al.   DIABETES

Secretion and Dipeptidyl Peptidase-4-Mediated Metabolism of Incretin Hormones after a Mixed Meal or Glucose Ingestion in Obese Compared to Lean, Nondiabetic Men

(2009) Richard D. Carr et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

(2009) Jonathan W Day et al.   Nature Chemical Biology

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE