PIEZO1 and TRPV4, which Are Distinct Mechano-Sensors in the Osteoblastic MC3T3-E1 Cells, Modify Cell-Proliferation

The mechanosensitive Piezo1 channel is required for bone formation

(2019) Weijia Sun et al.   eLife

PIEZO1 Channel Is a Potential Regulator of Synovial Sarcoma Cell-Viability

(2018) Takahisa Suzuki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TRPM3/TRPV4 regulates Ca2+-mediated RANKL/NFATc1 expression in osteoblasts

(2018) Aran Son et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Calcium signaling of in situ chondrocytes in articular cartilage under compressive loading: Roles of calcium sources and cell membrane ion channels

(2017) Mengxi Lv et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance

(2017) Baptiste Rode et al.   Nature Communications

Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes

(2017) M Rocio Servin-Vences et al.   eLife

Na+ entry through heteromeric TRPC4/C1 channels mediates (−)Englerin A-induced cytotoxicity in synovial sarcoma cells

(2017) Katsuhiko Muraki et al.   Scientific Reports

Piezo type mechanosensitive ion channel component 1 functions as a regulator of the cell fate determination of mesenchymal stem cells

(2017) Asuna Sugimoto et al.   Scientific Reports

Piezo1 Channels Are Inherently Mechanosensitive

(2016) Ruhma Syeda et al.   Cell Reports

Functional role of mechanosensitive ion channel Piezo1 in human periodontal ligament cells

(2015) Ying Jin et al.   ANGLE ORTHODONTIST

Shear stress-induced Ca2+ elevation is mediated by autocrine-acting glutamate in osteoblastic MC3T3-E1 cells

(2015) Norika Tsuchiya et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Chemical activation of the mechanotransduction channel Piezo1

(2015) Ruhma Syeda et al.   eLife

Inserted rest period resensitizes MC3T3-E1 cells to fluid shear stress in a time-dependent manner via F-actin-regulated mechanosensitive channel(s)

(2014) Xiaoyuan Gong et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

(2014) Whasil Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading

(2014) C. J. O'Conor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osteoblastic differentiation enhances expression of TRPV4 that is required for calcium oscillation induced by mechanical force

(2013) Takafumi Suzuki et al.   BONE

The puzzle of TRPV4 channelopathies

(2013) Bernd Nilius et al.   EMBO REPORTS

TRPV4 partially participates in proliferation of human brain capillary endothelial cells

(2013) Noriyuki Hatano et al.   LIFE SCIENCES

Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

(2012) R. Zarychanski et al.   BLOOD

Mechanical Signaling for Bone Modeling and Remodeling

(2012) Alexander G. Robling et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading

(2012) Shane A Lloyd et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

Loss of the Integrin-Activating Transmembrane Protein Fam38A (Piezo1) Promotes a Switch to a Reduced Integrin-Dependent Mode of Cell Migration

(2012) Brian J. McHugh et al.   PLoS One

The Involvement of TRP Channels in Bone Homeostasis

(2012) Liesbet Lieben et al.   Frontiers in Endocrinology

Mutations in TRPV4 cause an inherited arthropathy of hands and feet

(2011) Shireen R Lamandé et al.   NATURE GENETICS

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Expression of transient receptor potential (TRP) channels in human and murine osteoblast-like cells

(2009) Elie Abed et al.   MOLECULAR MEMBRANE BIOLOGY

Depth-dependent analysis of the role of collagen fibrils, fixed charges and fluid in the pericellular matrix of articular cartilage on chondrocyte mechanics

(2008) Rami K Korhonen et al.   JOURNAL OF BIOMECHANICS

Transient receptor potential vanilloid 4 deficiency suppresses unloading-induced bone loss

(2008) Fumitaka Mizoguchi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca2+- and ATP-dependent in MC3T3-E1 osteoblasts

(2007) Dawei Liu et al.   BONE