Inducible Cardiac-Specific Deletion of Sirt1 in Male Mice Reveals Progressive Cardiac Dysfunction and Sensitization of the Heart to Pressure Overload

Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress

(2019) Guiping Luo et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Mitochondrial Morphology, Dynamics, and Function in Human Pressure Overload or Ischemic Heart Disease With Preserved or Reduced Ejection Fraction

(2019) Antoine H. Chaanine et al.   Circulation-Heart Failure

Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca 2+ -ATPase in Heart Failure

(2019) Przemyslaw A Gorski et al.   CIRCULATION RESEARCH

SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection

(2018) Nunzia D'Onofrio et al.   ANTIOXIDANTS & REDOX SIGNALING

Sirtuin 1 activation attenuates cardiac fibrosis in a rodent pressure overload model by modifying Smad2/3 transactivation

(2018) Antoinette Bugyei-Twum et al.   CARDIOVASCULAR RESEARCH

Cardiomyocyte-specific deletion of Sirt1 gene sensitizes myocardium to ischaemia and reperfusion injury

(2018) Lin Wang et al.   CARDIOVASCULAR RESEARCH

SIRT1 increases cardiomyocyte binucleation in the heart development

(2018) Alexandra N Shin et al.   Oncotarget

PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis

(2018) Maayan Waldman et al.   EXPERIMENTAL CELL RESEARCH

Sirtuin 1 protects the aging heart from contractile dysfunction mediated through the inhibition of endoplasmic reticulum stress-mediated apoptosis in cardiac-specific Sirtuin 1 knockout mouse model

(2017) Yu-Juei Hsu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cobalamin and folate protect mitochondrial and contractile functions in a murine model of cardiac pressure overload

(2017) Jérôme Piquereau et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation

(2016) Alexandre Prola et al.   CELL DEATH AND DIFFERENTIATION

The role of sirtuins in cardiac disease

(2015) Shouji Matsushima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Reduced SIRT1 expression correlates with enhanced oxidative stress in compensated and decompensated heart failure

(2015) Feridun Akkafa et al.   Redox Biology

Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction

(2014) Julien Maizel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Protective role of PARK2/Parkin in sepsis-induced cardiac contractile and mitochondrial dysfunction

(2013) Jérôme Piquereau et al.   Autophagy

Cardiac fibrosis in mice expressing an inducible myocardial-specific Cre driver

(2013) J. Lexow et al.   Disease Models & Mechanisms

Moderate and high amounts of tamoxifen in  MHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death

(2013) K. Bersell et al.   Disease Models & Mechanisms

SIRT1 and energy metabolism

(2012) X. Li   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease

(2012) Dao-Fu Dai et al.   ANTIOXIDANTS & REDOX SIGNALING

Emerging beneficial roles of sirtuins in heart failure

(2012) Masaya Tanno et al.   BASIC RESEARCH IN CARDIOLOGY

PARP-2 knockdown protects cardiomyocytes from hypertrophy via activation of SIRT1

(2012) Biao Geng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Suppression of ERR targets by a PPARα/Sirt1 complex in the failing heart

(2012) Shin-ichi Oka et al.   CELL CYCLE

Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart

(2012) A. Planavila et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Protection of the Heart Against Ischemia/Reperfusion by Silent Information Regulator 1

(2012) Takanobu Yamamoto et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Systolic dysfunction in cardiac-specific ligand-inducible MerCreMer transgenic mice

(2011) Michael E. Hall et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway

(2011) Shinichi Oka et al.   Cell Metabolism

Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice

(2011) Tsuneaki Kawashima et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

(2011) N. R. Sundaresan et al.   Science Signaling

PGC-1 coactivators in the cardiovascular system

(2011) Ian S. Patten et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Silent Information Regulator 1 Protects the Heart From Ischemia/Reperfusion

(2010) Chiao-Po Hsu et al.   CIRCULATION

Postnatal development of mouse heart: formation of energetic microdomains

(2010) Jérôme Piquereau et al.   JOURNAL OF PHYSIOLOGY-LONDON

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 

(2008) R. Ventura-Clapier et al.   CARDIOVASCULAR RESEARCH

PGC-1α and ERRα target gene downregulation is a signature of the failing human heart

(2008) Smita Sihag et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells

(2008) Andrey V Kuznetsov et al.   Nature Protocols