期刊
BIOMATERIALS
卷 74, 期 -, 页码 280-291出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.10.004
关键词
Liposomes; Gold nanoparticles; Cluster bomb structure; Reconstruction; Multi-order drug release
资金
- Natural Science Foundation of China [31470916, 31200695, 31500769]
- Program for New Century Excellent Talents in University [NCET-100816]
- Fundamental Research Funds for the Central Universities [2015PT036, 2016PT014]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Open Project Program of MOE Key Laboratory of Drug Quality Control and Pharmacovigilance [DQCP2015MS01]
Hybrid drug delivery system containing both organic and inorganic nanocarriers is expected to achieve its complementary advantages for the aim of improving the performance of antineoplastic drugs in tumor therapy. Here we report the use of liposomes and gold nanoparticles to construct a liposome with a hybrid Cluster Bomb structure and discuss its unique multi-order drug release property for liver tumor treatment. A very simple method is used for the hybrid liposome preparation and involves mixing two solutions containing liposomes loaded with either non-covalent or covalent Paclitaxel (PTX, namely free PTX or PTX-conjugated GNPs, respectively) by different ratio of volume (25:75, 50:50, 25:75, v/v). Various mixed liposomes were tested to determine the optimal conditions for maximum drug delivery. The optimized liposome was then tested using xenograft Heps tumor-bearing mice and showed the best efficacy for chemotherapeutic inhibition of tumor at PTX liposome: PTX-conjugated GNP liposome of 25:75 ratio (v/v). This system allows for simple and easy preparation while providing a more accurate site- and time-release mode for tumor treatment using antitumor drugs. (C) 2015 Elsevier Ltd. All rights reserved.
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