Article
Chemistry, Multidisciplinary
Paola Aguei-Gonzalez, Tal M. Dankovich, Silvio O. Rizzoli, Nhu T. N. Phan
Summary: By using gold nanoprobes for NanoSIMS imaging, specific molecular imaging with highly selective identification of proteins and sensitive SIMS detection has been achieved. This enables the correlation of cellular isotopic turnover with the positions of specific proteins and organelles, enhancing understanding of functional and structural relationships.
Article
Chemistry, Multidisciplinary
Tho Duc Khanh Nguyen, Stefania Rabasco, Alicia A. Lork, Andre Du Toit, Andrew G. Ewing
Summary: In this study, TEM and NanoSIMS imaging were used to quantify subvesicular compartments and measure the partial release fraction of C-13-dopamine in cellular nanovesicles. Three modes of exocytosis were examined and it was found that there was no correlation between vesicle size and the fraction of partial release. The presence of isotopic dopamine indicated vesicle content, while an I-127-labelled drug was used to identify vesicles that underwent partial release.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yuejia Song, Yaqian Huang, Fang Zhou, Jinsong Ding, Wenhu Zhou
Summary: This review summarizes the recent progress of macrophage-targeted nanomedicine for chronic diseases immunotherapy. The origin, polarization, and biological functions of macrophages are introduced. The disorder of macrophages in different chronic diseases is reviewed, and the pathological contributions of macrophages in representative diseases are discussed in detail. Strategies to regulate macrophages for disease immunotherapy, with a focus on bio-functional nanomaterials, are summarized. Methods for macrophage-targeting delivery nanosystems are discussed. Finally, the potential clinical translation and the development of novel macrophage-targeting nanomedicine for precise, effective, and biosafe therapy are speculated.
CHINESE CHEMICAL LETTERS
(2022)
Review
Neurosciences
Seoyeon Won, Jeongyeon An, Hwayoung Song, Subin Im, Geunho You, Seungho Lee, Kyo-in Koo, Chang Ho Hwang
Summary: Currently, neurointervention, surgery, medication, and CNS stimulation are the main treatments for CNS diseases. However, these methods have limitations and the development of targeted delivery methods is necessary. Recent research has focused on spatiotemporally direct and indirect targeted delivery methods to minimize side effects and improve patient's quality of life.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Cheng Gao, Qingfu Wang, Junyan Li, Cheryl H. T. Kwong, Jianwen Wei, Beibei Xie, Siyu Lu, Simon M. Y. Lee, Ruibing Wang
Summary: This study reports an in vivo strategy to construct cell-based nanomedicine carriers using bacteria-mimetic gold nanoparticles, which are selectively phagocytosed by immune cells and self-assemble into intracellular aggregates. The optimized carriers improve drug delivery and enhance antitumor immunotherapy through photothermal treatment and immune checkpoint blockade.
Article
Nanoscience & Nanotechnology
Hanghang Fang, Yongjie Sha, Liang Yang, Jingjing Jiang, Lichen Yin, Jiaying Li, Bin Li, Bert Klumperman, Zhiyuan Zhong, Fenghua Meng
Summary: By nano-formulating hydroxychloroquine and designing it as a macrophage-targeted nanotherapeutic, it is possible to achieve highly effective treatment for rheumatoid arthritis. This therapeutic approach can induce repolarization of macrophages towards an anti-inflammatory phenotype, effectively reducing inflammation, and has shown significant therapeutic effects in mouse models.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Nanoscience & Nanotechnology
Hanxiao Liu, Hui Lv, Xuehui Duan, Yan Du, Yixuan Tang, Wei Xu
Summary: Macrophages undergo abnormal polarization in diseases, disrupting tissue regulation and impairing normal behavior. Nanomedicine offers customized drug delivery systems targeting macrophages, with potential for improved efficacy and reduced side effects. This review explores the roles of macrophages in major diseases, provides an overview of targeted drug delivery strategies, and evaluates the strengths and limitations of existing approaches.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Pharmacology & Pharmacy
Lanlan Fan, Zheng Wang, Dunyun Shi
Summary: Melanoma, a highly lethal form of skin cancer, can be treated with targeted nanoparticle drug delivery systems. Nanoparticles functionalized with different ligands are used to deliver drugs specifically to melanoma cells, reducing systemic toxicity. Coating nanoparticles with melanoma or immune cell membranes further enhances drug accumulation at the tumor site and improves therapeutic effects. This review highlights recent advances in targeted nanoparticle drug delivery systems for melanoma therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemical Research Methods
Youyou Li, Wenbo Han, Chunbai He, Xiaomin Jiang, Yingjie Fan, Wenbin Lin
Summary: The study demonstrated the design of carb/pyro nanoscale coordination polymer nanoparticles for the treatment of breast and colorectal cancer, showing promising anticancer efficacy in mouse models. Additionally, the combination therapy of carb/pyro with light irradiation and an anti-CD47 antibody achieved complete eradication of tumors in certain mice.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Evangelia Bolli, Maximilian Scherger, Sana M. Arnouk, Ana Rita Pombo Antunes, David Strassburger, Moritz Urschbach, Judith Stickdorn, Karen De Vlaminck, Kiavash Movahedi, Hans Joachim Rader, Sophie Hernot, Pol Besenius, Jo A. Van Ginderachter, Lutz Nuhn
Summary: The site-specific and quantitative coupling of Toll-like receptor agonist with single chain antibody fragments can repolarize macrophages, leading to a decline in tumor growth and enhancement of anti-tumor immune responses.
Review
Chemistry, Multidisciplinary
Luyao Dai, Shuaijun Li, Qian Hao, Ruina Zhou, Hui Zhou, Wenxi Lei, Huafeng Kang, Hao Wu, Yuanpei Li, Xiaobin Ma
Summary: Low-density lipoprotein (LDL) is a crucial component in lipid metabolism control and has unique physicochemical properties that make it an ideal targeted delivery carrier. This review covers the structure, composition, advantages, defects, and reconstruction of LDL delivery systems. It also summarizes the research status and progress of LDL as a targeted diagnosis and therapy tool, as well as its potential clinical applications.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Haidi Feng, Lu Zhao, Zhiqiang Bai, Zhihui Xin, Chaoyu Wang, Lizhen Liu, Jinping Song, Haifei Zhang, Yunfeng Bai, Feng Feng
Summary: In this study, an aptamer modified nanoplatform was designed for active-targeted chemo-photodynamic therapy of tumors. The nanoplatform showed enhanced therapeutic effect and active targeting efficiency under 808 nm laser irradiation.
Article
Materials Science, Multidisciplinary
Xu Xu, Chengge Jiao, Kexue Li, Min Hao, Katie. L. Moore, Timothy. L. Burnett, Xiaorong Zhou
Summary: High-spatial-resolution secondary ion mass spectrometry is a powerful tool for mapping lithium at nanoscale lateral resolution. Two state-of-the-art methods demonstrate the visualization of nanoscale Li-rich phases in an aluminium-lithium alloy, providing insight into the distribution and size of T-1 (Al2CuLi) precipitates. Correlation with high resolution electron microscopy confirms the identification of T-1 precipitates and their sizes observed during SIMS mapping.
MATERIALS CHARACTERIZATION
(2021)
Article
Materials Science, Multidisciplinary
Shuyu Shi, Hongze Ren, Yujie Xie, Meihua Yu, Yu Chen, Liqun Yang
Summary: This article provides an overview of advanced nanoengineering technologies for the delivery of neurotherapeutics, explaining how nanotherapeutics overcome the blood-brain barriers for enhanced therapeutic effects in CNS diseases. It discusses typical paradigms of nanomaterials and their impacts on the treatment of central nervous system disorders.
Review
Medicine, Research & Experimental
Zeinab Jan, Samaneh Mollazadeh, Khalil Abnous, Seyed Mohammad Taghdisi, Abolghasem Danesh, Mohammad Ramezani, Mona Alibolandi
Summary: Multiple sclerosis is a neurodegenerative disease of the central nervous system that requires timely and effective management. Nanoscale platforms offer practical and ideal approaches to improve conventional therapies and have potential in the diagnosis and treatment of MS.
MOLECULAR PHARMACEUTICS
(2022)
Review
Psychology, Developmental
Nicole Stuart, Andrew Whitehouse, Romina Palermo, Ellen Bothe, Nicholas Badcock
Summary: Reduced eye contact early in life may be a factor in the development of autism spectrum disorder, but there are conflicting theories about the neural mechanisms involved. The amygdala theory suggests that reduced eye contact is due to a hypoactive amygdala that fails to recognize eyes as important. In contrast, the eye avoidance hypothesis proposes that amygdala hyperactivity leads to eye avoidance. A review of studies found that most supported the eye avoidance hypothesis, indicating that individuals on the autism spectrum use eye avoidance to reduce amygdala-related hyperarousal.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Clinical Neurology
Gabrielle K. King, Louise M. Goodes, Carly Hartshorn, Jeffery Thavaseelan, Sheryl Jonescu, Anne Watts, Matthew Rawlins, Peter Woodland, Emma-Leigh Synnott, Trent Barrett, Dickon Hayne, Peter Boan, Sarah A. Dunlop
Summary: Intravesical hyaluronic acid with chondroitin sulphate (HA+CS) instillations can effectively and safely prevent urinary tract infections after spinal cord injury. The treatment course is well-tolerated in both acute and chronic spinal cord injury patients, although recruitment is more challenging in the acute setting.
JOURNAL OF SPINAL CORD MEDICINE
(2023)
Article
Geriatrics & Gerontology
Shaun J. Markovic, Sarah C. Hellewell, Vincent Dore, Ying Xia, Brendan R. Scott, Jeremiah J. Peiffer, Melinda Fitzgerald, Belinda M. Brown
Summary: The study found that a history of mild traumatic brain injury (mTBI) may lead to alterations in grey matter volume in the aging brain. However, variations in cardiorespiratory fitness (CRF) level did not influence the differences in brain volume found based on mTBI exposure status.
Article
Clinical Neurology
Peter Bragge, Breanna Wright, Emily Grundy, Denise Goodwin, Aleksandra Gozt, Lucy Clynes, Mia Calabritto, Melinda Fitzgerald
Summary: Based on a national survey and series of roundtables, researchers found that community-based prevention and support of traumatic brain injury (TBI) are challenging and underresearched. They identified three key themes: accessible, nationally consistent plain-language guidelines; building research literacy; and knowing your role in TBI identification and management.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2023)
Review
Critical Care Medicine
Robert McNamara, Shiv Meka, James Anstey, Daniel Fatovich, Luke Haseler, Toby Jeffcote, Andrew Udy, Rinaldo Bellomo, Melinda Fitzgerald
Summary: Traumatic intracranial hypertension (tIH) is a common complication of moderate to severe traumatic brain injury (m-sTBI) that can be lethal. The development of technology to predict tIH and administer interventions prior to the rise in intracranial pressure (ICP) has been a focus of research. In 2022, the first operationalizable tIH prediction system was developed, allowing for proactive management and protection of patients from potential harm. This review discusses the approaches to ICP forecasting and tIH prediction algorithms that form the foundation for this operational system, offering valuable insights for clinicians and researchers interested in this technology.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Biodiversity Conservation
Shannon Dee, Thomas DeCarlo, Ivan Lozic, Jake Nilsen, Nicola K. Browne
Summary: Bioerosion on inshore reefs is expected to increase with global climate change reducing reef stability and accretionary potential. Most studies investigating bioerosion have focused on external grazers, such as parrotfish and urchins, whose biomass is more easily measured. Yet, cryptic endolithic bioeroders such as macroboring (worms, sponges and bivalves) and microboring taxa (fungus and algae) have the potential to be the dominant source of reef erosion, especially among inshore reef systems exposed to increased nutrient supply.
Article
Biochemistry & Molecular Biology
Brittney R. R. Lins, Chidozie C. C. Anyaegbu, Terence McGonigle, Sarah C. C. Hellewell, Parth Patel, Harry Reagan, Cara Rooke-Wiesner, Andrew Warnock, Michael Archer, Jan M. M. Hemmi, Carole Bartlett, Melinda Fitzgerald
Summary: Adolescence is a critical period of development characterized by social, emotional, and cognitive changes, which are believed to depend on white matter development. However, the impact of injury on adolescent white matter maturation is still unclear. This study investigated the effects of optic nerve injury during early adolescence on myelin structure. The results showed that injury in adolescence altered the developmental trajectory of myelin maturation, resulting in impaired myelin structure in adulthood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Francesca Buhagiar, Melinda Fitzgerald, Jason Bell, Sarah Hellewell, Samantha Moore, Carmela F. Pestell
Summary: This study aimed to explore the neurobiological characteristics of post-concussion symptoms through the association between PCSS scores, brain network connectivity (using qEEG) and cognition in undergraduates. Results showed that, contrary to expectations, there was more frontoparietal network dysregulation in the low PCSS score group. There was no significant difference in cognitive dysfunction between high and low PCSS scorers. Post-hoc analysis revealed that participants reporting a more recent mTBI had greater network dysregulation.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2023)
Review
Immunology
Brittney R. Lins, Chidozie C. Anyaegbu, Sarah C. Hellewell, Melissa Papini, Terence McGonigle, Luca De Prato, Matthew Shales, Melinda Fitzgerald
Summary: Traumatic brain injury is common and lacks approved pharmaceutical interventions, but recent research on the therapeutic benefits of cannabis and its active chemical constituents has shown promise in managing TBI. Cannabinoids interact with neurons, microglia, and astrocytes, exerting anti-inflammatory and neuroprotective effects.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Multidisciplinary Sciences
L. M. Otter, K. Eder, M. R. Kilburn, L. Yang, P. O'Reilly, D. B. Nowak, J. M. Cairney, D. E. Jacob
Summary: The authors investigated the crystallization pathways involved in the formation of nacre and how they affect the incorporation of trace elements. They found that nacre grows through a two-step process and crystallizes through localised dissolution and reprecipitation. These findings provide insights into the incorporation of trace elements in natural biominerals and their hierarchical ultrastructure.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Cameron W. Evans, Abigail Egid, Somayra S. A. Mamsa, David J. Paterson, Diwei Ho, Carole A. Bartlett, Brooke Fehily, Brittney R. Lins, Melinda Fitzgerald, Mark J. Hackett, Nicole M. Smith
Summary: Understanding the chemical events following trauma to the central nervous system could help identify causative mechanisms and potential interventions for protecting neural tissue. In a rat model of partial optic nerve transection injury, researchers used synchrotron X-ray fluorescence microscopy to map the distribution of metals and related elements in white matter tracts. The study found significant changes in copper levels and widespread metal imbalance in response to central nervous system trauma, suggesting that metal homeostasis may be a potential target for intervention in limiting damage following neural injuries.
ACS CHEMICAL NEUROSCIENCE
(2023)
Editorial Material
Surgery
Melinda Fitzgerald
ANZ JOURNAL OF SURGERY
(2023)
Article
Environmental Studies
Aaron Malone, Nicole M. Smith, Eliseo Zeballos Zeballos, Rolando Quispe Aquino, Ubaldo Tapia Huamani, Jeronimo Miguel Gutierrez Soncco, Guido Salas, Zacarias Madariaga Coaquira, Jose Herrera Bedoya
Summary: This paper examines conflicts in artisanal and small-scale mining (ASM), focusing on a case study from Arequipa, Peru. The study highlights structural factors such as limited access to mining concessions, ineffective formalization models, and state weakness that contribute to conflicts and violence in the ASM sector. These findings have relevance not only in Peru but also in other countries with significant ASM sectors.
EXTRACTIVE INDUSTRIES AND SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Nicholas B. Lawler, Arnold Ou, Jessica J. King, Cameron W. Evans, K. Swaminathan Iyer, Nicole M. Smith
Summary: DNA G-quadruplexes (G4s) have been identified as important targets for regulating gene expression and treating human diseases. Two ligands, GTC365 and GQC-05, were found to stabilize G4s with different specificities, leading to altered chromatin accessibility and modified DNA damage response pathways. This work highlights the potential of G4-stabilizing ligands for specific or global chromatin modulation.
Article
Biology
France Champenois, Annette D. George, Kenneth J. Mcnamara, Jeremy Shaw, Maria Cherdantseva
Summary: Frutexites-like microstructures were found in the Late Devonian reef complexes of the northern Canning Basin, Western Australia. Three types of microstructures were identified, each composed of different bacterial communities and exhibiting distinctive textures and compositions.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.