Article
Biochemistry & Molecular Biology
Ali Maruf, Malgorzata Milewska, Anna Lalik, Sebastian Student, Ilona Wandzik
Summary: In this study, acrylamide-based nanogels containing cationic groups and redox-sensitive crosslinkers were developed for cellular delivery of anti-miR21 (a-miR21). Successful miRNA loading was confirmed and stable miRNA release was achieved.
Article
Chemistry, Multidisciplinary
Rafael Itzhakov, Hagit Hak, Sudharsan Sadhasivam, Eduard Belausov, Elazar Fallik, Ziv Spiegelman, Edward Sionov, Elena Poverenov
Summary: This work successfully delivers bioactive molecules through designing biocompatible nanogel particles (NGPs) using modified nature-sourced building blocks. NGPs are able to deliver drugs and proteins to plant cells, and can co-deliver multiple biomolecules. Furthermore, NGPs successfully encapsulate amphotericin B and reduce its toxicity.
Article
Chemistry, Multidisciplinary
Rajesh Kumar, Dinesh Pratap Singh, Romina Munoz, Mongi Amami, Rajesh Kumar Singh, Shipra Singh, Vinod Kumar
Summary: This review article introduces the potential and research progress of graphene and its derivatives in biomedical applications, and summarizes their effects on human health and the environment.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Leonard Kaps, Anne Huppertsberg, Niklas Choteschovsky, Adrian Klefenz, Feyza Durak, Babara Schroers, Mustafa Diken, Emma Eichler, Sebastian Rosigkeit, Sascha Schmitt, Christian Leps, Alicia Schulze, Friedrich Foerster, Ernesto Bockamp, Bruno G. De Geest, Kaloian Koynov, Hans-Joachim Raeder, Stefan Tenzer, Federico Marini, Detlef Schuppan, Lutz Nuhn
Summary: In this study, liver fibrosis progression was prevented by repolarizing M2-type macrophages towards a non-fibrotic phenotype using a pH-degradable nanogel carrier system. The nanogels efficiently delivered the drug alendronate to nonparenchymal cells of fibrotic livers, reprogramming profibrotic M2 into antifibrotic M1 macrophages and preventing liver fibrosis progression. This approach has potential implications for the treatment of diseases driven by M2-type macrophages, including cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Chemistry, Multidisciplinary
Hemlata Kaurav, Dhriti Verma, Amit Bansal, Deepak N. Kapoor, Sandeep Sheth
Summary: Carbon dots (CDs), with particle size less than 10 nm, are carbon-based nanomaterials widely used in various applications such as novel drug delivery for cancer, ocular diseases, infectious diseases, and brain disorders. The biocompatibility, eco-friendliness, ease of synthesis, and low toxicity of CDs, along with their excellent chemical inertness, make them an effective nanocarrier system for delivering multi-functional drugs. This review summarizes the advancements in the past 5 years in utilizing CDs as nanocarriers for gene delivery, vaccine delivery, and antiviral delivery.
FRONTIERS IN CHEMISTRY
(2023)
Article
Oncology
Fatemeh Hashemi, Nasrin Mohajeri, Fatemeh Radnia, Nosratollah Zarghami
Summary: This study presents a biocompatible and affordable fluorescence nanocarrier for cell imaging in cancer therapy. The hybrid nanogel, composed of chitosan polymer, carbon dots (CDs), and an anti-cancer drug, demonstrated successful uptake into breast cancer cells and efficient drug release. The nanocarrier provides both therapeutic compounds and fluorescent agents, enhancing therapeutic efficacy and enabling cellular imaging.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Review
Polymer Science
Brielle Stawicki, Tyler Schacher, Hyunah Cho
Summary: Chemotherapy and radiation are mainstays in cancer treatment globally, but some therapies have limited specificity and cause harsh side effects in patients. Nanogels, as a unique drug delivery system, show promise in the treatment of brain cancer, despite complications such as handling and chemical stability. Ongoing development of nanogels offers a patient-centered approach for managing brain cancer.
Article
Chemistry, Multidisciplinary
Tianbao Chen, Jie Xu, Lijuan Zhu, Deyue Yan
Summary: Researchers developed a targeted nanodrug delivery system using the cationic amphiphilic chemodrug mitoxantrone (Mito), which interacts with Bcl-2 ASO through electrostatic interaction and self-assembles into nanoparticles (NP[Bcl-2/Mito]). NP[Bcl-2/Mito] protects the ASO from degradation during delivery and combines gene- and chemotherapies to improve the anticancer effect. Cancer cell membranes (CCMs) derived from homologous tumors were used to camouflage NP[Bcl-2/Mito] (NP[Bcl-2/Mito]@CCM) for immune escape and tumor targeting. Both in vitro and in vivo assessments demonstrate the excellent performance of NP[Bcl-2/Mito]@CCM for drug-resistant breast tumor therapy.
Article
Biotechnology & Applied Microbiology
Yuan Zhong, Ali Maruf, Kai Qu, Malgorzata Milewska, Ilona Wandzik, Nianlian Mou, Yu Cao, Wei Wu
Summary: Atherosclerosis is a common vascular disease characterized by cholesterol-driven plaque formation in arteries. Trehalose-releasing nanogels (TNG) have been developed to restore impaired autophagy and reduce lipid accumulation, leading to a decrease in atherosclerotic plaques.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Engineering, Multidisciplinary
Yu Wang, Cheng Zheng, Ye Wu, Bo Zhang, Cheng Hu, Chuan Guo, Qingquan Kong, Yunbing Wang
Summary: This study developed a self-strengthening hydrogel gene delivery system for the controlled and sustained delivery of antagomir-21 into the nucleus pulposus (NP) to treat intervertebral disc degeneration (IDD). The hydrogel prevented drug leakage, provided mechanical support, and maintained stability of the spinal segment. In vitro and in vivo testing demonstrated the excellent biocompatibility, degradability, anti-inflammatory effects, and ability to regulate the ECM's metabolic balance of the hybrid hydrogels.
COMPOSITES PART B-ENGINEERING
(2023)
Review
Chemistry, Medicinal
Bhushan Phafat, Sankha Bhattacharya
Summary: The use of quantum technology for drug delivery has the potential to enhance the effectiveness of treatments for rare diseases. Semiconductor nanoparticles known as quantum dots have unique properties that make them suitable for applications as medication carriers and biosensors. Recent advancements in research and clinical domains have enabled in-depth exploration of quantum dots. Notable progress has been made in the fluorescence bioimaging research of quantum dots, where they can be applied for gene transport, drug delivery, and improving the biocompatibility of other medications.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Linjiang Song, Jin Yang, Zeyi Qin, Chunqing Ou, Rui Luo, Wen Yang, Li Wang, Ning Wang, Shuang Ma, Qinjie Wu, Changyang Gong
Summary: A multi-targeting and on-demand non-coding RNA regulation nanoplatform (MTOR) is reported to precisely regulate dysregulated miRs in triple-negative breast cancer (TNBC), leading to significant suppression of TNBC growth, metastasis, and recurrence. MTOR can simultaneously downregulate miRNA-21 expression and upregulate miRNA-205 expression in TNBC, showing remarkable synergistic effects on the inhibition of tumor growth, metastasis, and recurrence.
Article
Chemistry, Multidisciplinary
Siyeong Lee, Changhee Woo, Chang Seok Ki
Summary: Pectin nanogels were fabricated as a transcutaneous antigen-delivery carrier using a thiol-norbornene photo-click reaction and ultrasonication. The nanogels showed uniform size, stability, and the ability to penetrate the stratum corneum and be internalized by dendritic cells.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Hiroki Tanaka, Shinya Hagiwara, Daiki Shirane, Takuma Yamakawa, Yuka Sato, Chika Matsumoto, Kota Ishizaki, Miho Hishinuma, Katsuyuki Chida, Kasumi Sasaki, Etsuo Yonemochi, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe, Takashi Tadokoro, Katsumi Maenaka, Sakura Taneichi, Yuta Nakai, Kota Tange, Yu Sakurai, Hidetaka Akita
Summary: There is a growing demand by researchers to test whether their own biological findings might be applicable for use in mRNA-based therapeutics, but the equipment and know-how required for manufacturing such nanoparticles is often inaccessible. A simple method for preparing mRNA-LNPs is prerequisite to encourage more innovation in mRNA therapeutics. This study reports on a method for encapsulating IVT-mRNA into LNPs by rehydrating a Ready-to-Use empty freeze-dried LNP formulation with IVT-mRNA solution followed by heating, and the resulting mRNA-LNPs had a similar structure compared to the mRNA-LNPs prepared by conventional microfluidic mixing. In vivo genome editing using these mRNA-LNPs was achieved.
Article
Chemistry, Multidisciplinary
Yongqiang Shi, Feng Gao, Qichun Zhang, Jinglun Yang
Summary: Covalent organic frameworks (COFs) are crystalline organic porous materials with porosity, large surface area, and biocompatibility, making them excellent candidates for various applications. Recent research has shown that COFs have great potential for biomedical applications such as photodynamic therapy, gene delivery, photothermal therapy, drug delivery, bioimaging, biosensing, and combined therapies. This review covers the recent progress of COF materials in these applications and discusses the challenges and future perspectives for using COFs in biology-facing applications.
Article
Engineering, Biomedical
Ji Sun Park, Han Na Yang, Se Won Yi, Jae-Hwan Kim, Keun-Hong Park
Article
Chemistry, Multidisciplinary
Hye Jin Kim, Jong Min Park, Sujin Lee, Suk Jun Hong, Ji-In Park, Min Suk Lee, Hee Seok Yang, Ji Sun Park, Keun-Hong Park
Summary: By controlling the size of the pockets in pocket-type micro-carriers, cell adhesion can be facilitated and adapted to cells of different sizes. A 1:1 ratio of F-127 to DOPA-bPEI, with F-127 concentration at 10 mg/ml, is suitable for adhering 20-30μm stem cells. The use of gold nanoparticles complex and dexamethasone in PMcs promotes cartilage differentiation.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
