Liquid‐liquid phase separation and fibrillation of the prion protein modulated by a high‐affinity DNA aptamer

Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death

(2019) Fatima Gasset-Rosa et al.   NEURON

Matter over mind: Liquid phase separation and neurodegeneration

(2019) Shana Elbaum-Garfinkle   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of p53 and prion protein aggregation by RNA

(2019) Yraima Cordeiro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A designer chaperone against prion diseases

(2019) Emiliano Biasini   Nature Biomedical Engineering

Stochasticity of Biological Soft Matter: Emerging Concepts in Intrinsically Disordered Proteins and Biological Phase Separation

(2019) Konstantin K. Turoverov et al.   TRENDS IN BIOCHEMICAL SCIENCES

Intrinsic Disorder-Based Emergence in Cellular Biology: Physiological and Pathological Liquid-Liquid Phase Transitions in Cells

(2019) April L. Darling et al.   Polymers

RNA modulates aggregation of the recombinant mammalian prion protein by direct interaction

(2019) Petar Stefanov Kovachev et al.   Scientific Reports

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding

(2018) Bálint Mészáros et al.   NUCLEIC ACIDS RESEARCH

RNA buffers the phase separation behavior of prion-like RNA binding proteins

(2018) Shovamayee Maharana et al.   SCIENCE

Liquid and Hydrogel Phases of PrPC Linked to Conformation Shifts and Triggered by Alzheimer’s Amyloid-β Oligomers

(2018) Mikhail A. Kostylev et al.   MOLECULAR CELL

Mutations in DDHD1 , encoding a phospholipase A1, is a novel cause of retinopathy and neurodegeneration with brain iron accumulation

(2017) Rodolphe Dard et al.   European Journal of Medical Genetics

Heterozygous mutations affecting the protein kinase domain ofCDK13cause a syndromic form of developmental delay and intellectual disability

(2017) Mark J Hamilton et al.   JOURNAL OF MEDICAL GENETICS

Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity

(2016) Menglong Zeng et al.   CELL

The “Jekyll and Hyde” Actions of Nucleic Acids on the Prion-like Aggregation of Proteins

(2016) Jerson L. Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

In Vivo Formation of Vacuolated Multi-phase Compartments Lacking Membranes

(2016) Hermann Broder Schmidt et al.   Cell Reports

The Zfhx3-Mediated Axis Regulates Sleep and Interval Timing in Mice

(2016) Edoardo Balzani et al.   Cell Reports

Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain

(2016) Joanna M Dragich et al.   eLife

Structural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core

(2016) Guilherme A. P. de Oliveira et al.   Scientific Reports

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

(2015) Yuan Lin et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

(2015) Tetsuro Murakami et al.   NEURON

Association of Brain DNA Methylation inSORL1,ABCA7,HLA-DRB5,SLC24A4, andBIN1With Pathological Diagnosis of Alzheimer Disease

(2015) Lei Yu et al.   JAMA Neurology

Elucidating Molecular Mass and Shape of a Neurotoxic Aβ Oligomer

(2014) Adriano Sebollela et al.   ACS Chemical Neuroscience

Parallel In-register Intermolecular β-Sheet Architectures for Prion-seeded Prion Protein (PrP) Amyloids

(2014) Bradley R. Groveman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase transitions of multivalent proteins can promote clustering of membrane receptors

(2014) Sudeep Banjade et al.   eLife

Protein amyloids develop an intrinsic fluorescence signature during aggregation

(2013) Fiona T. S. Chan et al.   ANALYST

Nonspecific Prion Protein–Nucleic Acid Interactions Lead to Different Aggregates and Cytotoxic Species

(2012) Bruno Macedo et al.   BIOCHEMISTRY

Cross-talk between prion protein and quadruplex-forming nucleic acids: a dynamic complex formation

(2012) Paola Cavaliere et al.   NUCLEIC ACIDS RESEARCH

A majority of the cancer/testis antigens are intrinsically disordered proteins

(2011) Krithika Rajagopalan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

PONDR-FIT: A meta-predictor of intrinsically disordered amino acids

(2010) Bin Xue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cellular factors implicated in prion replication

(2010) Karim Abid et al.   FEBS LETTERS

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Circular dichroism and conformational polymorphism of DNA

(2009) J. Kypr et al.   NUCLEIC ACIDS RESEARCH

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

A large ribonucleoprotein particle induced by cytoplasmic PrP shares striking similarities with the chromatoid body, an RNA granule predicted to function in posttranscriptional gene regulation

(2008) Simon Beaudoin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Binding of Recombinant but Not Endogenous Prion Protein to DNA Causes DNA Internalization and Expression in Mammalian Cells

(2008) Shaoman Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion Protein Complexed to N2a Cellular RNAs through Its N-terminal Domain Forms Aggregates and Is Toxic to Murine Neuroblastoma Cells

(2008) Mariana P. B. Gomes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intriguing nucleic-acid-binding features of mammalian prion protein

(2008) Jerson L. Silva et al.   TRENDS IN BIOCHEMICAL SCIENCES

Predicting ultraviolet spectrum of single stranded and double stranded deoxyribonucleic acids

(2007) Andrey V. Tataurov et al.   BIOPHYSICAL CHEMISTRY