Inflammation resolution and specialized pro-resolving lipid mediators in CNS diseases

Maresin 1 attenuates the inflammatory response and mitochondrial damage in mice with cerebral ischemia/reperfusion in a SIRT1-dependent manner

(2019) Wenjing Xian et al.   BRAIN RESEARCH

A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine

(2019) Jiesi Feng et al.   NEURON

Pro-resolving lipid mediators as therapeutic leads for cardiovascular diseases

(2019) Yuanyuan Cheng et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Lipoxin A4 protects against spinal cord injury via regulating Akt/nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 signaling

(2018) Tan Lu et al.   BIOMEDICINE & PHARMACOTHERAPY

Fish oil feeding attenuates neuroinflammatory gene expression without concomitant changes in brain eicosanoids and docosanoids in a mouse model of Alzheimer’s disease

(2018) Kathryn E. Hopperton et al.   BRAIN BEHAVIOR AND IMMUNITY

Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimer's disease

(2018) Alpdogan Kantarci et al.   EXPERIMENTAL NEUROLOGY

Accelerating the reversal of inflammatory pain with NPD1 and its receptor GPR37

(2018) Lintao Qu et al.   JOURNAL OF CLINICAL INVESTIGATION

Key roles for lipid mediators in the adaptive immune response

(2018) Parker F. Duffney et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of inflammation in the development of epilepsy

(2018) Amna Rana et al.   Journal of Neuroinflammation

Resolvin D1 Halts Remote Neuroinflammation and Improves Functional Recovery after Focal Brain Damage Via ALX/FPR2 Receptor-Regulated MicroRNAs

(2018) Elisa Bisicchia et al.   MOLECULAR NEUROBIOLOGY

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

(2018) Wei Cai et al.   PROGRESS IN NEUROBIOLOGY

Safety and tolerability of prescription omega-3 fatty acids: A systematic review and meta-analysis of randomized controlled trials

(2018) Cheng-Ho Chang et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

An Overview of the Biologic Effects of Omega-6 Oxylipins in Humans

(2018) Gregory C. Shearer et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Neuroinflammation markers and methyl alcohol induced toxic brain damage

(2018) Sergey Zakharov et al.   TOXICOLOGY LETTERS

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

(2018) Ju Youn Lee et al.   Nature Communications

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

(2018) Oliver Werz et al.   Nature Communications

Nanoparticle-Based Strategies to Treat Neuro-Inflammation

(2018) Rémy Poupot et al.   Materials

Resolvin D2 protects against cerebral ischemia/reperfusion injury in rats

(2018) Gang Zuo et al.   Molecular Brain

Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice

(2018) Linlin Zhang et al.   Frontiers in Pharmacology

Host Lipid Mediators in Leprosy: The Hypothesized Contributions to Pathogenesis

(2018) Carlos A. M. Silva et al.   Frontiers in Immunology

Ageing: Is there a role for arachidonic acid and other bioactive lipids? A review

(2018) Undurti N. Das   Journal of Advanced Research

Arachidonic acid: Physiological roles and potential health benefits – A review

(2018) Hatem Tallima et al.   Journal of Advanced Research

The atheroprotective role of lipoxin A4 prevents oxLDL-induced apoptotic signaling in macrophages via JNK pathway

(2018) Jingting Mai et al.   ATHEROSCLEROSIS

Targeting GSK3 signaling as a potential therapy of neurodegenerative diseases and aging

(2018) Przemysław Duda et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

1α,25-Dihydroxyvitamin D3 and Resolvin D1 Retune the Balance between Amyloid-β Phagocytosis and Inflammation in Alzheimer's Disease Patients

(2018) Mathew T. Mizwicki et al.   JOURNAL OF ALZHEIMERS DISEASE

Restoration of Lipoxin A4 Signaling Reduces Alzheimer's Disease-Like Pathology in the 3xTg-AD Mouse Model

(2018) Haley C. Dunn et al.   JOURNAL OF ALZHEIMERS DISEASE

Differential Regulation of Resolution in Inflammation induced by Amyloid-β42 and Lipopolysaccharides in Human Microglia

(2018) Mingqin Zhu et al.   JOURNAL OF ALZHEIMERS DISEASE

Global burden of traumatic brain and spinal cord injury

(2018) Jetan H Badhiwala et al.   LANCET NEUROLOGY

Resolution of inflammation in neuromyelitis optica spectrum disorders

(2018) Xu Wang et al.   Multiple Sclerosis and Related Disorders

Annexin A1 and specialized proresolving lipid mediators: promoting resolution as a therapeutic strategy in human inflammatory diseases

(2017) Luiza Oliveira Perucci et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

ADAM10 as a therapeutic target for brain diseases: from developmental disorders to Alzheimer’s disease

(2017) Elena Marcello et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

(2017) Charles N. Serhan   FASEB JOURNAL

The Emerging Role of Zinc in the Pathogenesis of Multiple Sclerosis

(2017) Bo Choi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

n-3 Polyunsaturated Fatty Acids: Promising Nutrients for Preventing Cardiovascular Disease

(2017) Shusuke Yagi et al.   Journal of Atherosclerosis and Thrombosis

Astrocyte-derived lipoxins A4 and B4 promote neuroprotection from acute and chronic injury

(2017) Izhar Livne-Bar et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvin RvD2 reduces hypothalamic inflammation and rescues mice from diet-induced obesity

(2017) Livia B. Pascoal et al.   Journal of Neuroinflammation

Insights into the Dual Role of Inflammation after Spinal Cord Injury

(2017) Ruslan Rust et al.   JOURNAL OF NEUROSCIENCE

Maresin 1 Promotes Inflammatory Resolution, Neuroprotection, and Functional Neurological Recovery After Spinal Cord Injury

(2017) Isaac Francos-Quijorna et al.   JOURNAL OF NEUROSCIENCE

Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2017) Valery L Feigin et al.   LANCET NEUROLOGY

Interplay Between n-3 and n-6 Long-Chain Polyunsaturated Fatty Acids and the Endocannabinoid System in Brain Protection and Repair

(2017) Simon C. Dyall   LIPIDS

Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties

(2017) Shalini Muralikumar et al.   Lipids in Health and Disease

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

(2017) Nan Chiang et al.   MOLECULAR ASPECTS OF MEDICINE

Microglia Responses in Acute and Chronic Neurological Diseases: What Microglia-Specific Transcriptomic Studies Taught (and did Not Teach) Us

(2017) Hélène E. Hirbec et al.   Frontiers in Aging Neuroscience

Targeting resolution of neuroinflammation after ischemic stroke with a lipoxin A4 analog: Protective mechanisms and long-term effects on neurological recovery

(2017) Kimberly E. Hawkins et al.   Brain and Behavior

Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke

(2017) Johanna Ruhnau et al.   Journal of Immunology Research

Anti-Inflammatory Targets for the Treatment of Reperfusion Injury in Stroke

(2017) Atsushi Mizuma et al.   Frontiers in Neurology

Lipoxin A4 encapsulated in PLGA microparticles accelerates wound healing of skin ulcers

(2017) Mouzarllem Barros Reis et al.   PLoS One

The pro-resolving lipid mediator Maresin 1 protects against cerebral ischemia/reperfusion injury by attenuating the pro-inflammatory response

(2016) Wenjing Xian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Localized delivery of low-density lipoprotein docosahexaenoic acid nanoparticles to the rat brain using focused ultrasound

(2016) Rohit S. Mulik et al.   BIOMATERIALS

Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice

(2016) Joana Viola et al.   CIRCULATION RESEARCH

IL-4 drives microglia and macrophages toward a phenotype conducive for tissue repair and functional recovery after spinal cord injury

(2016) Isaac Francos-Quijorna et al.   GLIA

Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of NontypeableHaemophilus influenzae

(2016) Amanda Croasdell et al.   JOURNAL OF IMMUNOLOGY

Increased Postexercise Lipoxin A4 Levels in Exhaled Breath Condensate in Asthmatic Children With Exercise-Induced Bronchoconstriction

(2016) Tahan F et al.   JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY

Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection

(2016) Alessandra Cadete Martini et al.   Journal of Neuroinflammation

Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines

(2016) Mousumi Ghosh et al.   Journal of Neuroinflammation

Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship

(2016) Xin Sun et al.   Journal of Neuroinflammation

Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS

(2016) Undurti N Das   Lipids in Health and Disease

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Resolution of inflammation: a new therapeutic frontier

(2016) James N. Fullerton et al.   NATURE REVIEWS DRUG DISCOVERY

Lipid mediators of inflammation in neurological injury: shifting the balance toward resolution

(2016) Jonathan Lifshitz et al.   Neural Regeneration Research

Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis

(2016) Daniel Cacabelos et al.   NEUROBIOLOGY OF DISEASE

Inflammation and Stroke: An Overview

(2016) Josef Anrather et al.   Neurotherapeutics

Redox modulation of cellular stress response and lipoxin A4 expression by Coriolus versicolor in rat brain: Relevance to Alzheimer's disease pathogenesis

(2016) A. Trovato et al.   NEUROTOXICOLOGY

Lipoxin A4 Preconditioning Attenuates Intestinal Ischemia Reperfusion Injury through Keap1/Nrf2 Pathway in a Lipoxin A4 Receptor Independent Manner

(2016) Xue Han et al.   Oxidative Medicine and Cellular Longevity

Infections in the spinal cord-injured population: a systematic review

(2016) L Y Garcia-Arguello et al.   SPINAL CORD

Inflammogenesis of Secondary Spinal Cord Injury

(2016) M. Akhtar Anwar et al.   Frontiers in Cellular Neuroscience

Annexin A1 and the Resolution of Inflammation: Modulation of Neutrophil Recruitment, Apoptosis, and Clearance

(2016) Michelle Amantéa Sugimoto et al.   Journal of Immunology Research

Emerging Roles for the Immune System in Traumatic Brain Injury

(2016) Celia A. McKee et al.   Frontiers in Immunology

Resolution of inflammation is altered in Alzheimer's disease

(2015) Xiuzhe Wang et al.   Alzheimers & Dementia

Activation of autophagy in macrophages by pro-resolving lipid mediators

(2015) Patricia Prieto et al.   Autophagy

Glucocorticoids enhance prolonged clearance of apoptotic cells by upregulating liver X receptor, peroxisome proliferator-activated receptor-δ and UCP2

(2015) Éva Garabuczi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse

(2015) Jordan L. Harrison et al.   BRAIN BEHAVIOR AND IMMUNITY

Treatment of Neuromyelitis Optica Spectrum Disorder: Acute, Preventive, and Symptomatic

(2015) Remi A. Kessler et al.   Current Treatment Options in Neurology

Targeting formyl peptide receptor 2 reduces leukocyte-endothelial interactions in a murine model of stroke

(2015) Helen K. Smith et al.   FASEB JOURNAL

Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair

(2015) Giovanna Leoni et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of n-3 FA supplementation on the release of proresolving lipid mediators by blood mononuclear cells: the OmegAD study

(2015) Xiuzhe Wang et al.   JOURNAL OF LIPID RESEARCH

Lipoxin A4 Activates Nrf2 Pathway and Ameliorates Cell Damage in Cultured Cortical Astrocytes Exposed to Oxygen-Glucose Deprivation/Reperfusion Insults

(2015) Le Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice

(2015) Renana Baratz et al.   Journal of Neuroinflammation

Interaction Studies of Resolvin E1 Analog (RX-10045) with Efflux Transporters

(2015) Kishore Cholkar et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis

(2015) Mingqin Zhu et al.   MOLECULAR NEUROBIOLOGY

GABA A currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis

(2015) Cristina Roseti et al.   NEUROBIOLOGY OF DISEASE

Reductions of docosahexaenoic acid-containing phosphatidylcholine levels in the anterior horn of an ALS mouse model

(2015) H. Arima et al.   NEUROSCIENCE

Oligomerization of Cu,Zn-Superoxide Dismutase (SOD1) by Docosahexaenoic Acid and Its Hydroperoxides In Vitro: Aggregation Dependence on Fatty Acid Unsaturation and Thiols

(2015) Patricia Postilione Appolinário et al.   PLoS One

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

(2015) Charles N. Serhan et al.   SEMINARS IN IMMUNOLOGY

Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation

(2015) Mauro Perretti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway

(2015) Tomoki Maekawa et al.   Nature Communications

Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA

(2015) Simon C. Dyall   Frontiers in Aging Neuroscience

Innate Immune Programing by Endotoxin and Its Pathological Consequences

(2015) Matthew C. Morris et al.   Frontiers in Immunology

Hippocampal Neuro-Networks and Dendritic Spine Perturbations in Epileptogenesis Are Attenuated by Neuroprotectin D1

(2015) Alberto E. Musto et al.   PLoS One

Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice

(2014) G. Ortiz-Munoz et al.   BLOOD

Combination Therapy of 15-Epi-Lipoxin A4 With Antibiotics Protects Mice From Escherichia coli–Induced Sepsis*

(2014) Tomomi Ueda et al.   CRITICAL CARE MEDICINE

Tuberculosis and the risk of infection with other intracellular bacteria: a population-based study

(2014) M. A. HUAMAN et al.   EPIDEMIOLOGY AND INFECTION

Annexin A4 is a promising therapeutic target for the treatment of platinum-resistant cancers

(2014) Shinya Matsuzaki et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Rapid Appearance of Resolvin Precursors in Inflammatory Exudates: Novel Mechanisms in Resolution

(2014) K. Kasuga et al.   JOURNAL OF IMMUNOLOGY

The Specialized Proresolving Mediator 17-HDHA Enhances the Antibody-Mediated Immune Response against Influenza Virus: A New Class of Adjuvant?

(2014) Sesquile Ramon et al.   JOURNAL OF IMMUNOLOGY

Aging Delays Resolution of Acute Inflammation in Mice: Reprogramming the Host Response with Novel Nano-Proresolving Medicines

(2014) Hildur H. Arnardottir et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 promotes the interleukin-4-induced alternative activation in BV-2 microglial cells

(2014) Longyan Li et al.   Journal of Neuroinflammation

Resolvin D1, a Metabolite of Omega-3 Polyunsaturated Fatty Acid, Decreases Post-Myocardial Infarct Depression

(2014) Kim Gilbert et al.   Marine Drugs

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Aspirin-triggered Lipoxin A4 attenuates mechanical allodynia in association with inhibiting spinal JAK2/STAT3 signaling in neuropathic pain in rats

(2014) Z.-F. Wang et al.   NEUROSCIENCE

Phospholipase A2 regulates eicosanoid class switching during inflammasome activation

(2014) P. C. Norris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroprotective Effects of Lipoxin A4 in Central Nervous System Pathologies

(2014) Alessandra Cadete Martini et al.   Biomed Research International

Aspirin-Triggered Lipoxin A4 Stimulates Alternative Activation of Microglia and Reduces Alzheimer Disease–Like Pathology in Mice

(2013) Rodrigo Medeiros et al.   AMERICAN JOURNAL OF PATHOLOGY

A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation

(2013) V. Brancaleone et al.   BLOOD

Lipoxin A4 attenuates brain damage and downregulates the production of pro-inflammatory cytokines and phosphorylated mitogen-activated protein kinases in a mouse model of traumatic brain injury

(2013) Cheng-Liang Luo et al.   BRAIN RESEARCH

Initial Immunopathogenesis of Multiple Sclerosis: Innate Immune Response

(2013) Norma Y. Hernández-Pedro et al.   Clinical & Developmental Immunology

Genome-wide Association Studies in Alzheimer’s Disease: A Review

(2013) Giuseppe Tosto et al.   Current Neurology and Neuroscience Reports

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms

(2013) Chuck T. Chen et al.   JOURNAL OF LIPID RESEARCH

Lipoxin A4Preconditioning and Postconditioning Protect Myocardial Ischemia/Reperfusion Injury in Rats

(2013) Qifeng Zhao et al.   MEDIATORS OF INFLAMMATION

Lipoxin A4 ameliorates cerebral ischaemia/reperfusion injury through upregulation of nuclear factor erythroid 2-related factor 2

(2013) Le Wu et al.   NEUROLOGICAL RESEARCH

Mortality in patients with multiple sclerosis

(2013) A. Scalfari et al.   NEUROLOGY

Inflammation and stroke

(2013) Yi-Bing Ouyang   NEUROSCIENCE LETTERS

Proresolution Lipid Mediators in Multiple Sclerosis — Differential, Disease Severity-Dependent Synthesis — A Clinical Pilot Trial

(2013) Harald Prüss et al.   PLoS One

Polyunsaturated Fatty Acid Metabolism Signature in Ischemia Differs from Reperfusion in Mouse Intestine

(2013) Thomas Gobbetti et al.   PLoS One

Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles

(2013) N. Kamaly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain-Immune Interactions and Ischemic Stroke

(2012) Costantino Iadecola   ARCHIVES OF NEUROLOGY

Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections

(2012) David M. Tobin et al.   CELL

Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke

(2012) Nicolas G. Bazan et al.   EXPERIMENTAL NEUROLOGY

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

(2012) Charles N. Serhan et al.   FASEB JOURNAL

Lipoxin A4 Inhibits 5-Lipoxygenase Translocation and Leukotrienes Biosynthesis to Exert a Neuroprotective Effect in Cerebral Ischemia/Reperfusion Injury

(2012) Le Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Ly6C+Ly6G−Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury

(2012) Hirokazu Saiwai et al.   JOURNAL OF NEUROCHEMISTRY

Resolvin E1 Inhibits Neuropathic Pain and Spinal Cord Microglial Activation Following Peripheral Nerve Injury

(2012) Zhen-Zhong Xu et al.   Journal of Neuroimmune Pharmacology

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Is multiple sclerosis a proresolution deficiency disorder?

(2012) Undurti N. Das   NUTRITION

Glial Tumor Necrosis Factor Alpha (TNFα) Generates Metaplastic Inhibition of Spinal Learning

(2012) J. Russell Huie et al.   PLoS One

Docosahexaenoic Acid Signaling Modulates Cell Survival in Experimental Ischemic Stroke Penumbra and Initiates Long-Term Repair in Young and Aged Rats

(2012) Tiffany N. Eady et al.   PLoS One

Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor

(2012) F. A. Pamplona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Immune and Inflammatory Mechanisms in ALS

(2011) P. A. McCombe et al.   CURRENT MOLECULAR MEDICINE

The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis

(2011) Alberto E. Musto et al.   EPILEPSIA

Spinal cord injury therapies in humans: an overview of current clinical trials and their potential effects on intrinsic CNS macrophages

(2011) John C Gensel et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Meta-Analysis of the Effects of Eicosapentaenoic Acid (EPA) in Clinical Trials in Depression

(2011) M. Elizabeth Sublette et al.   JOURNAL OF CLINICAL PSYCHIATRY

Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing

(2011) L. V. Norling et al.   JOURNAL OF IMMUNOLOGY

A Lipoxin A4 Analog Ameliorates Blood–Brain Barrier Dysfunction and Reduces MMP-9 Expression in a Rat Model of Focal Cerebral Ischemia–Reperfusion Injury

(2011) Yan Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Endogenous Signaling by Omega-3 Docosahexaenoic Acid-derived Mediators Sustains Homeostatic Synaptic and Circuitry Integrity

(2011) Nicolas G. Bazan et al.   MOLECULAR NEUROBIOLOGY

Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

(2011) Yuhai Zhao et al.   PLoS One

Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation

(2010) Charles N. Serhan   AMERICAN JOURNAL OF PATHOLOGY

Lipoxin A 4 analogue protects brain and reduces inflammation in a rat model of focal cerebral ischemia reperfusion

(2010) Xi-Hong Ye et al.   BRAIN RESEARCH

Lipoxins: regulators of resolution

(2010) Aidan Ryan et al.   CURRENT OPINION IN PHARMACOLOGY

Human and economic burden of stroke

(2009) A. Di Carlo   AGE AND AGEING

Acute Changes in Dietary  -3 and  -6 Polyunsaturated Fatty Acids Have a Pronounced Impact on Survival following Ischemic Renal Injury and Formation of Renoprotective Docosahexaenoic Acid-Derived Protectin D1

(2009) I. R. Hassan et al.   JOURNAL OF IMMUNOLOGY

Brain phospholipid arachidonic acid half-lives are not altered following 15 weeks of N-3 polyunsaturated fatty acid adequate or deprived diet

(2009) Joshua T. Green et al.   JOURNAL OF LIPID RESEARCH

Synthesis of Lipoxin A4 by 5-Lipoxygenase Mediates PPAR -Dependent, Neuroprotective Effects of Rosiglitazone in Experimental Stroke

(2009) M. Sobrado et al.   JOURNAL OF NEUROSCIENCE

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood–brain barrier: An in situ cerebral perfusion study

(2009) Melissa Ouellet et al.   NEUROCHEMISTRY INTERNATIONAL

Dietary saturated and unsaturated fats as determinants of blood pressure and vascular function

(2009) Wendy L. Hall   NUTRITION RESEARCH REVIEWS

Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties

(2008) Nicos A. Petasis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury

(2007) Dustin J. Donnelly et al.   EXPERIMENTAL NEUROLOGY