Article
Biochemistry & Molecular Biology
Antonio Recchiuti, Sara Patruno, Domenico Mattoscio, Elisa Isopi, Antonella Pomilio, Alessia Lamolinara, Manuela Iezzi, Romina Pecce, Mario Romano
Summary: An excessive and unresolved inflammatory response is one of the reasons underlying severe COVID-19, and the investigation of endogenous pathways to resolve inflammation is crucial for mitigating inflammation caused by SARS-CoV-2 infection. Individuals with preexisting pathologies like cystic fibrosis exhibit some specificity in immune responses to SARS-CoV-2. Furthermore, resolvins D1 and D2 have beneficial regulatory effects in reducing SARS-CoV-2-induced inflammation.
Article
Immunology
Wei Xiong, Han Wang, Hongyan Zhang, Yanmei Xing, Wenli Gao, Lengfeng Chen, Lixin Chen, Zhongliang Dai
Summary: It has been discovered that neuroinflammation caused by microglial activation is the cause of depression associated with sepsis. An endogenous lipid mediator called resolvin D1 (RvD1) has anti-inflammatory effects in a sepsis model. However, it is still unclear if the effects of RvD1 on inflammatory responses are regulated by microglial autophagy.
INFLAMMOPHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nada Joe Melhem, Mouna Chajadine, Ingrid Gomez, Kiave-Yune Howangyin, Marion Bouvet, Camille Knosp, Yanyi Sun, Marie Rouanet, Ludivine Laurans, Olivier Cazorla, Mathilde Lemitre, Jose Vilar, Ziad Mallat, Alain Tedgui, Hafid Ait-Oufella, Jean-Sebastien Hulot, Jacques Callebert, Jean-Marie Launay, Jeremy Fauconnier, Jean-Sebastien Silvestre, Soraya Taleb
Summary: The study suggests that IDO could be a potential therapeutic target in acute myocardial infarction, as its deficiency limits cardiac injury and dysfunction after MI, with endothelial cell-specific deletion of IDO showing improvement in cardiac function and reduction in adverse ventricular remodeling.
Article
Cardiac & Cardiovascular Systems
Bastian Bruns, Ricarda Daub, Thomas Schmitz, Maria Hamze-Sinno, Sebastian Spaich, Matthias Dewenter, Chrysovalandis Schwale, Peter Gass, Miriam Vogt, Hugo Katus, Wolfgang Herzog, Hans-Christoph Friederich, Norbert Frey, Jobst-Hendrik Schultz, Johannes Backs
Summary: Deficient central MR/GR signaling may contribute to poor outcomes in patients with depression after myocardial infarction (MI), possibly explaining the lack of effectiveness of antidepressant treatment.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xueyi Weng, Haipeng Tan, Zheyong Huang, Jing Chen, Ning Zhang, Qiaozi Wang, Qiyu Li, Jinfeng Gao, Dili Sun, Wusiman Yakufu, Zhengmin Wang, Weiyan Li, Guangrui Zhu, Zhiqing Pang, Yanan Song, Juying Qian, Junbo Ge
Summary: A platelet-bionic, ROS-responsive RvD1 delivery platform has been developed in this study, which enables targeted delivery and controlled release of RvD1 by hijacking circulating chemotactic monocytes, leading to improved cardiac function.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Are Annesonn Kalstad, Peder Langeland Myhre, Kristian Laake, Sjur Hansen Tveit, Erik Berg Schmidt, Paal Smith, Dennis Winston Trygve Nilsen, Arnljot Tveit, Morten Wang Fagerland, Svein Solheim, Ingebjorg Seljeflot, Harald Arnesen
Summary: The addition of 1.8g n-3 PUFA to standard care did not result in a significant reduction in cardiovascular events during a 2-year follow-up in elderly patients with recent AMI.
Article
Nutrition & Dietetics
Meng Yuan, Yue Zhang, Tong Hua, Xiang-Li Liu, Tong Liu, Ru-Yu Yuan, Guang-Ping Li, Yi Zhu, Xu Zhang
Summary: The study suggests that Omega-3 polyunsaturated fatty acid (omega-3 PUFA) supplementation may improve lipid metabolism and endothelial function by affecting eicosanoid metabolic status during convalescent healing after acute myocardial infarction.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Andreas Baranyi, Dietmar Enko, Andreas Meinitzer, Dirk Von Lewinski, Hans-Bernd Rothenhausler, Leonhard Harpf, Heimo Traninger, Barbara Obermayer-Pietsch, Birgit M. Harb, Melanie Schweinzer, Moritz Platzer, Sieglinde Zelzer
Summary: This study aims to investigate the relationship between AMI-induced depression and immune system suppression, and found MPO may serve as a potential biomarker for AMI-induced depression.
Article
Biochemistry & Molecular Biology
Hadi Karimkhani, Mete Ozkoc, Paria Shojaolsadati, Kubilay Uzuner, Dilek Burukoglu Donmez, Gungor Kanbak
Summary: The study evaluated the cardiac protective effect of boric acid and omega-3 against myocardial infarction, potentially due to the suppression of pro-inflammatory cytokines and natriuretic peptides in rats. Results demonstrated that boric acid and omega-3 have protective effects on MI by reducing inflammation and cardiac damage.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Nutrition & Dietetics
Zhen-Sen Chen, Mu-Ming Yu, Kuo Wang, Xiang-Long Meng, Yan-Cun Liu, Song-Tao Shou, Yan-Fen Chai
Summary: This study aimed to investigate whether omega-3 polyunsaturated fatty acids (PUFAs) have a protective effect on sepsis-induced cardiomyopathy (SIC). The findings showed that pretreatment with omega-3 PUFAs can attenuate cardiomyocyte apoptosis, reduce the production of proinflammatory cytokines, improve SIC, and increase the survival rate of septic mice.
Article
Cell Biology
Lijia Zhang, Lifang Lv, Nan Zheng, Ruotong Li, Rui Yang, Tianyu Li, Yingnan Li, Yingqi Liu, Hongwei Luo, Xuelian Li, Yuhong Zhou, Hongli Shan, Bing Bai, Haihai Liang
Summary: Sox4 plays a role in promoting cardiomyocyte apoptosis during myocardial infarction by regulating Bim expression, and silencing Sox4 can attenuate cardiomyocyte apoptosis, suggesting it as a potential therapeutic target for MI.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Peng Yu, Shuai Song, Xiaokai Zhang, Shujun Cui, Gang Wei, Zihang Huang, Linqi Zeng, Ting Ni, Aijun Sun
Summary: This study revealed the regulatory mechanism of APA in post-MI HF and identified the potential therapeutic effect of the APA-regulated gene AVEN in treating HF.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Tomohiko Shimizu, Tsugumichi Saito, Haruka Aoki-Saito, Shuichi Okada, Hiroyuki Ikeda, Takashi Nakakura, Hayato Fukuda, Syota Arai, Kouichi Fujiwara, Yasuyo Nakajima, Kazuhiro Horiguchi, Sayaka Yamada, Emi Ishida, Takeshi Hisada, Satoshi Shuto, Masanobu Yamada
Summary: The study showed that resolvin E3 (RvE3) may improve insulin sensitivity and enhance glucose uptake in adipocytes by activating the PI3K/Akt signaling pathways, potentially regulating glucose homeostasis and serving as a therapeutic target for treating obesity-associated diabetes.
Article
Pharmacology & Pharmacy
Zhiyu He, Xiaojun Zeng, Deke Zhou, Peiying Liu, Dunzheng Han, Lingling Xu, Tong Bu, Jinping Wang, Mengmeng Ke, Xiudi Pan, Yipeng Du, Hao Xue, Dongfeng Lu, Bihui Luo
Summary: This study identifies the novel ability of lncRNA Chaer in regulating cardiomyocyte apoptosis by promoting phosphorylation of AMPK in acute myocardial infarction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Liangpeng Li, Wenbin Fu, Xue Gong, Zhi Chen, Luxun Tang, Dezhong Yang, Qiao Liao, Xuewei Xia, Hao Wu, Chao Liu, Miao Tian, Andi Zeng, Lin Zhou, Pedro A. Jose, Ken Chen, Wei Eric Wang, Chunyu Zeng
Summary: The study aims to investigate the role of GRK4 in the pathogenesis and progression of myocardial infarction (MI). Results showed that GRK4 expression was increased in the heart after MI, and overexpression of GRK4 aggravated cardiac infarction and dysfunction while specific gene knockout ameliorated these effects. GRK4 inhibited autophagy and promoted cardiomyocyte apoptosis, effects mediated by HDAC4 phosphorylation and a decrease in beclin-1 expression, leading to greater impairment of cardiac function in MI patients carrying the GRK4 A486V variant.
EUROPEAN HEART JOURNAL
(2021)