RAS/RAF/MEK/ERK, PI3K/PTEN/AKT/mTORC1 and TP53 pathways and regulatory miRs as therapeutic targets in hepatocellular carcinoma
出版年份 2019 全文链接
标题
RAS/RAF/MEK/ERK, PI3K/PTEN/AKT/mTORC1 and TP53 pathways and regulatory miRs as therapeutic targets in hepatocellular carcinoma
作者
关键词
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出版物
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 23, Issue 11, Pages 915-929
出版商
Informa UK Limited
发表日期
2019-10-29
DOI
10.1080/14728222.2019.1685501
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Involvement of long non-coding RNA HULC (highly up-regulated in liver cancer) in cancer pathogenesis and implications for therapeutic Intervention
- (2019) Christiane Klec et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- microRNA-944 inhibits the malignancy of hepatocellular carcinoma by directly targeting IGF-1R and deactivating the PI3K/Akt signaling pathway
- (2019) Lili Lv et al. Cancer Management and Research
- TREM2 acts as a tumor suppressor in hepatocellular carcinoma by targeting the PI3K/Akt/β-catenin pathway
- (2019) Wenqing Tang et al. Oncogenesis
- Dynamic expression of ZNF382 and its tumor-suppressor role in hepatitis B virus-related hepatocellular carcinogenesis
- (2019) Siwen Dang et al. ONCOGENE
- Secalonic Acid-F, a Novel Mycotoxin, Represses the Progression of Hepatocellular Carcinoma via MARCH1 Regulation of the PI3K/AKT/β-catenin Signaling Pathway
- (2019) Lulu Xie et al. MOLECULES
- miR‐885‐5p plays an accomplice role in liver cancer by instigating TIGAR expression via targeting its promoter
- (2019) Shubiao Zou et al. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
- Sequestosome 1/p62-related pathways as therapeutic targets in hepatocellular carcinoma
- (2019) Helmut Denk et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Aberrant lipid metabolism as a therapeutic target in liver cancer
- (2019) Evans D. Pope et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response
- (2019) Stefano Caruso et al. GASTROENTEROLOGY
- The mTORC 2‐Akt cascade is crucial for c‐Myc to promote hepatocarcinogenesis in mice and men
- (2019) Zhong Xu et al. HEPATOLOGY
- CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis
- (2019) Xiao-Lu Ma et al. Journal of Hematology & Oncology
- MiR-122 Targets SerpinB3 and Is Involved in Sorafenib Resistance in Hepatocellular Carcinoma
- (2019) Cristian Turato et al. Journal of Clinical Medicine
- miR-300 regulates the epithelial-mesenchymal transition and invasion of hepatocellular carcinoma by targeting the FAK/PI3K/AKT signaling pathway
- (2018) Rongchang Wang et al. BIOMEDICINE & PHARMACOTHERAPY
- Antiproliferative effect of urolithin A, the ellagic acid-derived colonic metabolite, on hepatocellular carcinoma HepG2.2.15 cells by targeting Lin28a/let-7a axis
- (2018) Zhenpeng Qiu et al. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
- Targeted delivery of microRNA-199a-3p using self-assembled dipeptide nanoparticles efficiently reduces hepatocellular carcinoma in mice
- (2018) Aditi Varshney et al. HEPATOLOGY
- miR-221 suppression through nanoparticle-based miRNA delivery system for hepatocellular carcinoma therapy and its diagnosis as a potential biomarker
- (2018) Feng Li et al. International Journal of Nanomedicine
- C-Myc-dependent repression of two oncogenic miRNA clusters contributes to triptolide-induced cell death in hepatocellular carcinoma cells
- (2018) Shu-Guang Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- microRNA-26a induces a mitochondrial apoptosis mediated by p53 through targeting to inhibit Mcl1 in human hepatocellular carcinoma
- (2018) Xiao-Mei Gao et al. OncoTargets and Therapy
- miR-106b-5p promotes stem cell-like properties of hepatocellular carcinoma cells by targeting PTEN via PI3K/Akt pathway
- (2018) Dong-Min Shi et al. OncoTargets and Therapy
- The epigenetically regulated miR-494 associates with stem-cell phenotype and induces sorafenib resistance in hepatocellular carcinoma
- (2018) Daniela Pollutri et al. Cell Death & Disease
- Targeting FLT3 Mutations in Acute Myeloid Leukemia
- (2018) Riad El Fakih et al. Cells
- Propofol Inhibits Proliferation, Migration, Invasion and Promotes Apoptosis Through Down-Regulating miR-374a in Hepatocarcinoma Cell Lines
- (2018) Sheng-Qun Liu et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Targeting ZBP-89 for the treatment of hepatocellular carcinoma
- (2018) Nuozhou Wang et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- miR-365 Regulates Liver Cancer Stem Cells via RAC1 pathway
- (2018) Ze-Bin Jiang et al. MOLECULAR CARCINOGENESIS
- MiR-494-3p promotes PI3K/AKT pathway hyperactivation and human hepatocellular carcinoma progression by targeting PTEN
- (2018) Hui Lin et al. Scientific Reports
- α-pinene regulates miR-221 and induces G2/M phase cell cycle arrest in human hepatocellular carcinoma cells
- (2018) Qiuxiang Xu et al. BIOSCIENCE REPORTS
- circLARP4 induces cellular senescence through regulating miR-761/RUNX3/p53/p21 signaling in hepatocellular carcinoma
- (2018) Zhiqiang Chen et al. CANCER SCIENCE
- PI3Kδ Is a Therapeutic Target in Hepatocellular Carcinoma
- (2018) Eunkyong Ko et al. HEPATOLOGY
- MicroRNA-645 represses hepatocellular carcinoma progression by inhibiting SOX30-mediated p53 transcriptional activation
- (2018) Jie Tao et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- LINC01133 aggravates the progression of hepatocellular carcinoma by activating the PI3K/AKT pathway
- (2018) Yong‐Fa Zheng et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Interaction of lncRNA-MALAT1 and miR-124 regulates HBx-induced cancer stem cell properties in HepG2 through PI3K/Akt signaling
- (2018) Bo He et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- MicroRNA-621 Acts as a Tumor Radiosensitizer by Directly Targeting SETDB1 in Hepatocellular Carcinoma
- (2018) Yingjie Shao et al. MOLECULAR THERAPY
- Up-Regulation of Phosphatase in Regenerating Liver-3 (PRL-3) Contributes to Malignant Progression of Hepatocellular Carcinoma by Activating Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)/Phosphoinositide 3-Kinase (PI3K)/AKT Signaling Pathway
- (2018) Bing-Hui Li et al. MEDICAL SCIENCE MONITOR
- Cabozantinib in the treatment of hepatocellular carcinoma
- (2017) Mary Linton B Peters et al. Future Oncology
- Wild type Kirsten rat sarcoma is a novel microRNA-622-regulated therapeutic target for hepatocellular carcinoma and contributes to sorafenib resistance
- (2017) Peter Dietrich et al. GUT
- Targeting β-catenin in hepatocellular cancers induced by coexpression of mutant β-catenin and K-Ras in mice
- (2017) Junyan Tao et al. HEPATOLOGY
- Delivery of miR-375 and doxorubicin hydrochloride by lipid-coated hollow mesoporous silica nanoparticles to overcome multiple drug resistance in hepatocellular carcinoma
- (2017) Huiying Xue et al. International Journal of Nanomedicine
- The long noncoding RNAPCAT-1links the microRNA miR-215 to oncogene CRKL-mediated signaling in hepatocellular carcinoma
- (2017) Yanli Ren et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway
- (2017) Qiuran Xu et al. Molecular Cancer
- Lipid Nanoparticle–Mediated Delivery of Anti-miR-17 Family Oligonucleotide Suppresses Hepatocellular Carcinoma Growth
- (2017) Xinqiang Huang et al. MOLECULAR CANCER THERAPEUTICS
- FLT3 Inhibitors in Acute Myeloid Leukemia: Current Status and Future Directions
- (2017) Maria Larrosa-Garcia et al. MOLECULAR CANCER THERAPEUTICS
- Identification of Four Oxidative Stress-Responsive MicroRNAs, miR-34a-5p, miR-1915-3p, miR-638, and miR-150-3p, in Hepatocellular Carcinoma
- (2017) Yong Wan et al. Oxidative Medicine and Cellular Longevity
- Targeting the Ras/Raf/MEK/ERK pathway in hepatocellular carcinoma
- (2017) Sufang Yang et al. Oncology Letters
- Anti-miR-17 therapy delays tumorigenesis in MYC-driven hepatocellular carcinoma (HCC)
- (2017) Renumathy Dhanasekaran et al. Oncotarget
- IGF-1R tyrosine kinase inhibitors and Vitamin K1 enhance the antitumor effects of Regorafenib in HCC cell lines
- (2017) Maria Grazia Refolo et al. Oncotarget
- miR-564 inhibits hepatocellular carcinoma cell proliferation and invasion by targeting the GRB2-ERK1/2-AKT axis
- (2017) Chaojie Liang et al. Oncotarget
- MiR-101 and doxorubicin codelivered by liposomes suppressing malignant properties of hepatocellular carcinoma
- (2017) Fei Xu et al. Cancer Medicine
- The Oncogenic Role of Tribbles 1 in Hepatocellular Carcinoma Is Mediated by a Feedback Loop Involving microRNA-23a and p53
- (2017) Ying Ye et al. Frontiers in Physiology
- MiR-375 and Doxorubicin Co-delivered by Liposomes for Combination Therapy of Hepatocellular Carcinoma
- (2017) Yin-Ping Fan et al. Molecular Therapy-Nucleic Acids
- 0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop
- (2017) Caixia Xia et al. Scientific Reports
- Carboxymethyl Dextran-Stabilized Polyethylenimine-Poly(epsilon-caprolactone) Nanoparticles-Mediated Modulation of MicroRNA-34a Expression via Small-Molecule Modulator for Hepatocellular Carcinoma Therapy
- (2016) Xiongwei Deng et al. ACS Applied Materials & Interfaces
- Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity—Diverse effects on cell growth, metabolism and cancer
- (2016) James A. McCubrey et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- MicroRNA-24 increases hepatocellular carcinoma cell metastasis and invasion by targeting p53: miR-24 targeted p53
- (2016) Li Chen et al. BIOMEDICINE & PHARMACOTHERAPY
- MicroRNA-122 confers sorafenib resistance to hepatocellular carcinoma cells by targeting IGF-1R to regulate RAS/RAF/ERK signaling pathways
- (2016) Yanmin Xu et al. CANCER LETTERS
- The liver-specific microRNA-122*, the complementary strand of microRNA-122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitry
- (2016) Alina Simerzin et al. HEPATOLOGY
- Knockdown of miR-25 increases the sensitivity of liver cancer stem cells to TRAIL-induced apoptosis via PTEN/PI3K/Akt/Bad signaling pathway
- (2016) Xiaoning Feng et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors
- (2016) Muhammad S. Beg et al. INVESTIGATIONAL NEW DRUGS
- Genetic profiling of hepatocellular carcinoma using next-generation sequencing
- (2016) Kornelius Schulze et al. JOURNAL OF HEPATOLOGY
- Over-expression of the miR-483-3p overcomes the miR-145/TP53 pro-apoptotic loop in hepatocellular carcinoma
- (2016) Laura Lupini et al. Oncotarget
- V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy
- (2016) Karin Bartel et al. Oncotarget
- Anti-tumor Efficiency of Lipid-coated Cisplatin Nanoparticles Co-loaded with MicroRNA-375
- (2016) Tan Yang et al. Theranostics
- The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis
- (2015) Guohua Lou et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications
- (2015) Bénédicte Delire et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Hepatocellular carcinoma treatment over sorafenib: epigenetics, microRNAs and microenvironment. Is there a light at the end of the tunnel?
- (2015) Antonio Gnoni et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway
- (2015) Heng Wu et al. GUT
- MicroRNA-519a promotes tumor growth by targeting PTEN/PI3K/AKT signaling in hepatocellular carcinoma
- (2015) KANGSHENG TU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- MicroRNA-215 is upregulated by treatment with Adriamycin and leads to the chemoresistance of hepatocellular carcinoma cells and tissues
- (2015) LI WANG et al. Molecular Medicine Reports
- Targeting EMP3 suppresses proliferation and invasion of hepatocellular carcinoma cells through inactivation of PI3K/Akt pathway
- (2015) Yi-Hsien Hsieh et al. Oncotarget
- MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation
- (2015) Jianxin Jiang et al. Oncotarget
- MiR-101 targets DUSP1 to regulate the TGF-β secretion in sorafenib inhibits macrophage-induced growth of hepatocarcinoma
- (2015) Xufu Wei et al. Oncotarget
- Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma
- (2015) Florian Ewald et al. Journal of Cancer
- EASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma
- (2015) et al. JOURNAL OF HEPATOLOGY
- Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades
- (2015) James Andrew McCubrey et al. Oncotarget
- Targeted therapy for hepatocellular carcinoma: novel agents on the horizon
- (2015) Melchiorre Cervello et al. Oncotarget
- MicroRNA-224 upregulation and AKT activation synergistically predict poor prognosis in patients with hepatocellular carcinoma
- (2014) Lingxiang Yu et al. Cancer Epidemiology
- Hepatocellular Carcinoma: Reasons for Phase III Failure and Novel Perspectives on Trial Design
- (2014) J. M. Llovet et al. CLINICAL CANCER RESEARCH
- miR-222 regulates sorafenib resistance and enhance tumorigenicity in hepatocellular carcinoma
- (2014) KAI LIU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Mutation analysis of key genes in RAS/RAF and PI3K/PTEN pathways in Chinese patients with hepatocellular carcinoma
- (2014) WENMIN HOU et al. Oncology Letters
- Identification of driver genes in hepatocellular carcinoma by exome sequencing
- (2013) Sean P. Cleary et al. HEPATOLOGY
- Lactosylated gramicidin-based lipid nanoparticles (Lac-GLN) for targeted delivery of anti-miR-155 to hepatocellular carcinoma
- (2013) Mengzi Zhang et al. JOURNAL OF CONTROLLED RELEASE
- Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor
- (2013) Shu-hao Hsu et al. Nanomedicine-Nanotechnology Biology and Medicine
- MicroRNA-34a Targets Bcl-2 and Sensitizes Human Hepatocellular Carcinoma Cells to Sorafenib Treatment
- (2013) Fan Yang et al. TECHNOLOGY IN CANCER RESEARCH & TREATMENT
- miR-224 functions as an onco-miRNA in hepatocellular carcinoma cells by activating AKT signaling
- (2012) DONGLAI MA et al. Oncology Letters
- Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor
- (2011) R. Mallon et al. CLINICAL CANCER RESEARCH
- Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways
- (2011) Cecilia Scisciani et al. JOURNAL OF HEPATOLOGY
- miR-221 overexpression contributes to liver tumorigenesis
- (2009) P. Pineau et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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