Building Up Quaternary Stereocenters Through Biocatalyzed Direct Insertion of Carbon Nucleophiles on Ketones

Synthesis of Branched-Chain Sugars with a DHAP-Dependent Aldolase: Ketones are Electrophile Substrates of Rhamnulose-1-phosphate Aldolases

(2018) Victor Laurent et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Application of Threonine Aldolases for the Asymmetric Synthesis of α-Quaternary α-Amino Acids

(2018) Julia Blesl et al.   ChemCatChem

Industrial Applications of Enzymes: Recent Advances, Techniques, and Outlooks

(2018) Jordan Chapman et al.   Catalysts

Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens

(2018) Jan-Patrick Steitz et al.   CHEMBIOCHEM

Tailoring Proteins to Re-Evolve Nature: A Short Review

(2018) Angelica Jimenez-Rosales et al.   MOLECULAR BIOTECHNOLOGY

Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals

(2018) Matthew P. Thompson et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biocatalysis in the Pharmaceutical Industry: The Need for Speed

(2017) Matthew D. Truppo   ACS Medicinal Chemistry Letters

Substrate-Determined Diastereoselectivity in an Enzymatic Carboligation

(2016) Patrizia Lehwald et al.   CHEMBIOCHEM

Modern Approaches to Discovering New Hydroxynitrile Lyases for Biocatalysis

(2016) Santosh Kumar Padhi   CHEMBIOCHEM

Thiamine-Diphosphate-Dependent Enzymes as Catalytic Tools for the Asymmetric Benzoin-Type Reaction

(2016) Pier Paolo Giovannini et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enzyme-catalyzed asymmetric construction of chiral tertiary alcohols via aldol reaction using proteinase

(2016) Rui Li et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Recent Developments in the Synthesis of Chiral Compounds with Quaternary Centers by Organocatalytic Cascade Reactions

(2016) Li Tian et al.   Asian Journal of Organic Chemistry

Catalytic Enantioselective Construction of Quaternary Stereocenters: Assembly of Key Building Blocks for the Synthesis of Biologically Active Molecules

(2015) Yiyang Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

L -Rhamnulose-1-phosphate Aldolase from Thermotoga maritima in Organic Synthesis: One-Pot Multistep Reactions for the Preparation of Imino- and Nitrocyclitols

(2015) Isabel Oroz-Guinea et al.   ADVANCED SYNTHESIS & CATALYSIS

EngineeredL-Serine Hydroxymethyltransferase fromStreptococcus thermophilusfor the Synthesis of α,α-Dialkyl-α-Amino Acids

(2015) Karel Hernandez et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzymatic Chemoselective Aldehyde-Ketone Cross-Couplings through the Polarity Reversal of Methylacetoin

(2015) Giovanni Bernacchia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expanding the threonine aldolase toolbox for the asymmetric synthesis of tertiary α-amino acids

(2015) Kateryna Fesko et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

l-Rhamnulose-1-phosphate and l-fuculose-1-phosphate aldolase mediated multi-enzyme cascade systems for nitrocyclitol synthesis

(2015) Flora Camps Bres et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Hydroxynitrile Lyase-Catalyzed Synthesis of Enantiopure Cyanohydrins in Biocatalytic Active Static Emulsions (BASE) with Suppression of the Non-Enzymatic Side Reaction

(2014) Jan von Langermann et al.   ADVANCED SYNTHESIS & CATALYSIS

Extended Reaction Scope of Thiamine Diphosphate Dependent Cyclohexane-1,2-dione Hydrolase: From CC Bond Cleavage to CC Bond Ligation

(2014) Sabrina Loschonsky et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Aliphatic and α-Halogenated Ketone Cyanohydrins with the Hydroxynitrile Lyase from Manihot esculenta

(2014) Johannes Diebler et al.   ChemCatChem

Expanding the scope of enzymatic carboligation reactions in flow-mode: production of optically active tertiary alcohols with packed-bed micro-bioreactors

(2014) P. P. Giovannini et al.   GREEN CHEMISTRY

Catalytic enantioselective synthesis of quaternary carbon stereocentres

(2014) Kyle W. Quasdorf et al.   NATURE

Immobilisation of hydroxynitrile lyases

(2013) Ulf Hanefeld   CHEMICAL SOCIETY REVIEWS

Strategies for the discovery and engineering of enzymes for biocatalysis

(2013) Timo Davids et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Biocatalysis in Organic Chemistry and Biotechnology: Past, Present, and Future

(2013) Manfred T. Reetz   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fructose-6-phosphate aldolases as versatile biocatalysts for nitrocyclitol syntheses

(2013) Flora Camps Bres et al.   TETRAHEDRON-ASYMMETRY

Recent Developments in Enzymatic Asymmetric CC Bond Formation

(2012) Michael Müller   ADVANCED SYNTHESIS & CATALYSIS

An enzymatic approach to the synthesis of optically pure (3R)- and (3S)-enantiomers of green tea flavor compound 3-hydroxy-3-methylnonane-2,4-dione

(2012) Olga Bortolini et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

The use of enzymes in organic synthesis and the life sciences: perspectives from the Swiss Industrial Biocatalysis Consortium (SIBC)

(2012) Hans-Peter Meyer et al.   Catalysis Science & Technology

Coupling Chemical Modification and Immobilization to Improve the Catalytic Performance of Enzymes

(2011) Rafael C. Rodrigues et al.   ADVANCED SYNTHESIS & CATALYSIS

Discovery and Protein Engineering of Biocatalysts for Organic Synthesis

(2011) Geoffrey A. Behrens et al.   ADVANCED SYNTHESIS & CATALYSIS

Enzymatic diastereo- and enantioselective synthesis of α-alkyl-α,β-dihydroxyketones

(2011) Pier Paolo Giovannini et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Strategies for discovery and improvement of enzyme function: state of the art and opportunities

(2011) Praveen Kaul et al.   Microbial Biotechnology

A Mutant D-Fructose-6-Phosphate Aldolase (Ala129Ser) with Improved Affinity towards Dihydroxyacetone for the Synthesis of Polyhydroxylated Compounds

(2010) José A. Castillo et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Intermolecular Aldehyde-Ketone Cross-Coupling through an Enzymatic Carboligation Reaction

(2010) Patrizia Lehwald et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure of a Class I Tagatose-1,6-bisphosphate Aldolase

(2010) Clotilde LowKam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacillus stearothermophilus acetylacetoin synthase: A new catalyst for C–C bond formation

(2010) Pier Paolo Giovannini et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Activated α,β-Unsaturated Aldehydes as Substrate of Dihydroxyacetone Phosphate (DHAP)-Dependent Aldolases in the Context of a Multienzyme System

(2009) Israel Sánchez-Moreno et al.   ADVANCED SYNTHESIS & CATALYSIS

Biocatalytic Access to α,α-Dialkyl-α-amino Acids by a Mechanism-Based Approach

(2009) Kateryna Fesko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fructose-1,6-Bisphosphate Aldolase-Mediated Synthesis of Aminocyclitols (Analogues of Valiolamine) and their Evaluation as Glycosidase Inhibitors

(2009) Lahssen El Blidi et al.   ChemCatChem

Enzymatic Synthesis of Optically Active Tertiary Alcohols: Expanding the Biocatalysis Toolbox

(2008) Robert Kourist et al.   CHEMBIOCHEM