Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

(2019) Rhys Anderson et al.   EMBO JOURNAL

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

(2019) Mikolaj Ogrodnik et al.   Cell Metabolism

Stem cell competition orchestrates skin homeostasis and ageing

(2019) Nan Liu et al.   NATURE

Telomere dysfunction promotes transdifferentiation of human fibroblasts into myofibroblasts

(2018) Neetu Razdan et al.   AGING CELL

Rapamycin improves healthspan but not inflammaging in nfκb1 −/− mice

(2018) Clara Correia-Melo et al.   AGING CELL

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Telomeres and Cell Senescence - Size Matters Not

(2017) Stella Victorelli et al.   EBioMedicine

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin

(2016) Michael C. Velarde et al.   Aging-US

Oxidation events and skin aging

(2015) A. Kammeyer et al.   AGEING RESEARCH REVIEWS

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease

(2015) Jodie Birch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A three-dimensional skin equivalent reflecting some aspects ofin vivoaged skin

(2015) Johanna Diekmann et al.   EXPERIMENTAL DERMATOLOGY

Skin aging, gene expression and calcium

(2015) Mark Rinnerthaler et al.   EXPERIMENTAL GERONTOLOGY

P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age

(2015) Mariëtte E. C. Waaijer et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

In vitro 3-D model based on extending time of culture for studying chronological epidermis aging

(2015) Morgan Dos Santos et al.   MATRIX BIOLOGY

Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells

(2015) Michael C. Velarde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

CXCR3 Signaling in BRAFWT Melanoma Increases IL-8 Expression and Tumorigenicity

(2015) Molly H. Jenkins et al.   PLoS One

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Stable Cellular Senescence Is Associated with Persistent DDR Activation

(2014) Marzia Fumagalli et al.   PLoS One

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

(2013) Albert R. Davalos et al.   JOURNAL OF CELL BIOLOGY

p16INK4A Influences the Aging Phenotype in the Living Skin Equivalent

(2013) Jean Adamus et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Wnt signaling potentiates nevogenesis

(2013) J. S. Pawlikowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

The number of p16INK4a positive cells in human skin reflects biological age

(2012) Mariëtte E.C. Waaijer et al.   AGING CELL

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

(2012) Anitha Suram et al.   EMBO JOURNAL

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study

(2011) Mariette E. C. Waaijer et al.   AGE

Differentiated melanocyte cell division occurs in vivo and is promoted by mutations in Mitf

(2011) Kerrie L. Taylor et al.   DEVELOPMENT

Five dysfunctional telomeres predict onset of senescence in human cells

(2011) Zeenia Kaul et al.   EMBO REPORTS

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen

(2010) Jean-Philippe Coppé et al.   PLoS One

Human Telomeres Are Hypersensitive to UV-Induced DNA Damage and Refractory to Repair

(2010) Patrick J. Rochette et al.   PLoS Genetics

Epidermal homeostasis: a balancing act of stem cells in the skin

(2009) Cédric Blanpain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY