Article
Medicine, General & Internal
Shaowei Jiang, Yang Wang, Liang Chen, Honghua Mu, Connor Meaney, Yiwen Fan, Janesh Pillay, Hairong Wang, Jincheng Zhang, Shuming Pan, Chengjin Gao
Summary: This study investigates the associations among serum levels of PAI-1, PAI-1 gene polymorphisms, immunological indicators, and clinical outcomes in septic patients. The results suggest that genetic polymorphisms of PAI-1 can affect serum levels of PAI-1, which in turn may influence mortality by affecting neutrophil activity.
CHINESE MEDICAL JOURNAL
(2023)
Article
Health Care Sciences & Services
Hee Young Cho, Han Sung Park, Eun Hee Ahn, Eun Ju Ko, Hyeon Woo Park, Young Ran Kim, Ji Hyang Kim, Woo Sik Lee, Nam Keun Kim
Summary: The study revealed that PAI-1 rs1050955 and REN 10795 rs5707 alleles may decrease the risk of RPL, while the tPA rs4646972 genotype may increase the risk of RPL.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Rawan Altalhi, Nikoletta Pechlivani, Ramzi A. Ajjan
Summary: Hypofibrinolysis is a key abnormality in diabetes, with elevated levels of PAI-1 playing a significant role. Strategies to inhibit PAI-1 function may lead to new antithrombotic agents that reduce vascular complications in diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Tobias Frischmuth, Kristian Hindberg, Pal Aukrust, Thor Ueland, Sigrid K. Braekkan, John-Bjarne Hansen, Vania M. Morelli
Summary: This study aimed to investigate the association between plasma PAI-1 levels and the risk of future incident VTE, as well as to explore the potential mediation of PAI-1 on the VTE risk in obesity.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Ziran Wang, Lingjun Kong, Guoju Luo, Han Zhang, Fengchun Sun, Wenjuan Liang, Wei Wu, Zijian Guo, Rui Zhang, Yaling Dou
Summary: This study aimed to investigate the clinical impact of the PAI-1 4G/5G polymorphism in Chinese patients with VTE. The results showed no significant correlation between the PAI-1 4G/5G polymorphism and VTE susceptibility, but differences were observed in neutrophil counts, NLR, recanalization, and recurrence status based on the genotype. Additionally, PAI-1 antigen levels were higher in the VTE group compared to the control group. These findings lay the foundation for the personalized management and monitoring of VTE patients using PAI-1 4G/5G polymorphism.
THROMBOSIS JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Machteld Sillen, Toshio Miyata, Douglas E. Vaughan, Sergei V. Strelkov, Paul J. Declerck
Summary: PAI-1 is a key regulator of the fibrinolytic system, with potential therapeutic significance in various pathological conditions. Small molecule inhibitors like TM5484 may inhibit PAI-1 by binding to the flexible joint region and inducing a substrate to inert form conversion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Otorhinolaryngology
Zhenxing Wei, Kunpeng Chang, Chongsheng Fan
Summary: Three eligible studies involving 519 subjects (241 cases, 278 controls) showed no statistically significant association between the 4G/5G polymorphism of PAI-1 gene and SSNHL in any model. Further well-designed studies covering a larger population are needed.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Hematology
Tae Ito, Yuko Suzuki, Hideto Sano, Naoki Honkura, Francis J. Castellino, Tetsumei Urano
Summary: The study demonstrates the existence of three distinct forms of high-molecular-weight complexes between tPA and PAI-1. Peptide sequence analysis revealed that these complexes consist of nonacylated-enzyme inhibitor complexes, with only a fraction of the population releasing free tPA under physiological conditions.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cell Biology
Yong-Han Su, Yi-Zhen Wu, David K. K. Ann, Jenny Ling-Yu Chen, Ching-Ying Kuo
Summary: Obesity is a risk factor for various cancers, including breast cancer. Adipose tissue disturbance in obesity is closely related to cancer progression and resistance to standard treatments. In this study, diet-induced obesity promoted tumor growth and reduced tumor response to radiotherapy in the mouse model of triple-negative breast cancer. Serpine1 was found to be elevated in the blood of obese mice and enriched in the tumor microenvironment.
CELL DEATH & DISEASE
(2023)
Review
Obstetrics & Gynecology
Hong Zeng, Dongmei He, Lian Hu, Wenmin Ma, Song Quan
Summary: This meta-analysis found that the homozygous genotype of PAI-1 -675 4G/4G may be a predisposing factor for recurrent implantation failure. Women with the PAI-1 4G/4G genotype are at higher risk. However, more high-quality studies are needed to confirm this conclusion.
REPRODUCTIVE SCIENCES
(2021)
Review
Immunology
Shao-Li Huang, Hong-Yi Xin, Guang-Gui Feng, Fu-Qing Wu, Zhi-Peng Feng, Zhou Xing, Xi-He Zhang, Hong-Wu Xin, Wen-Ying Luo
Summary: Venous thromboembolism is a common cardiovascular disease associated with the immune system and inflammatory factors. Platelets, miRNA, and the plasminogen-plasmin system are all involved in venous thrombosis, and extracellular vesicles also play a role in the development of thrombosis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Machteld Sillen, Paul J. Declerck
Summary: PAI-1 is the primary inhibitor of fibrinolysis, mainly through fast-acting inhibition of tPA and uPA, as well as interactions with biological ligands, affecting pericellular proteolysis and tissue remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Mudassir Wani, Abdullah Al-Mitwalli, Subhabrata Mukherjee, Ghulam Nabi, Bhaskar K. Somani, Jayasimha Abbaraju, Sanjeev Madaan
Summary: The aim of this study was to investigate the occurrence and risk factors of venous thromboembolism (VTE) in post-radical prostatectomy patients. It was found that the overall incidence of VTE in post-RP patients is 1%, and minimally invasive procedures and RP without pelvic lymph node dissection are associated with a lower risk of developing VTE. Additional pharmacological prophylaxis may not be necessary in all cases and should be considered in high-risk patients only.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Shengyuan Luo, Alexi Vasbinder, Jeanne M. Du-Fay-de-Lavallaz, Joanne Michelle D. Gomez, Tisha Suboc, Elizabeth Anderson, Annika Tekumulla, Husam Shadid, Hanna Berlin, Michael Pan, Tariq U. Azam, Ibrahim Khaleel, Kishan Padalia, Chelsea Meloche, Patrick O'Hayer, Tonimarie Catalan, Pennelope Blakely, Christopher Launius, Kingsley-Michael Amadi, Rodica Pop-Busui, Sven H. Loosen, Athanasios Chalkias, Frank Tacke, Evangelos J. Giamarellos-Bourboulis, Izzet Altintas, Jesper Eugen-Olsen, Kim A. Williams, Annabelle Santos Volgman, Jochen Reiser, Salim S. Hayek
Summary: Higher levels of soluble urokinase plasminogen activator receptor (suPAR) were found to be independently associated with an increased risk of venous thromboembolism (VTE) in COVID-19 hospitalized patients, regardless of D-dimer levels. Combining suPAR and D-dimer can help identify patients at low risk of developing VTE.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Editorial Material
Biochemistry & Molecular Biology
Hau C. Kwaan
Summary: The fibrinolytic system is composed of plasmin, plasminogen, activators, and inhibitors. It plays essential roles in physiological processes and the pathogenesis of disorders. Recent advancements offer opportunities for drug development in treating these disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Saeed Tofighi, Hamidreza Poorhosseini, Yaser Jenab, Mohammad Alidoosti, Mohammad Sadeghian, Mehdi Mehrani, Zhale Tabrizi, Parisa Hashemi
Summary: This study aimed to predict adverse clinical outcomes in STEMI patients treated with primary PCI using machine learning models. The results showed that the DRF and GBM models had the best performance in predicting major adverse cardiovascular events.
CLINICAL CARDIOLOGY
(2024)