A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?
出版年份 2021 全文链接
标题
A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 5, Pages 2721
出版商
MDPI AG
发表日期
2021-03-09
DOI
10.3390/ijms22052721
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Role of PAI-1 in hepatic steatosis and dyslipidemia
- (2021) Joshua A. Levine et al. Scientific Reports
- The Central Role of Fibrinolytic Response in COVID-19—A Hematologist’s Perspective
- (2021) Hau C. Kwaan et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484
- (2021) Machteld Sillen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Synergy between plasminogen activator inhibitor-1, α-synuclein, and neuroinflammation in Parkinson’s disease
- (2020) Carolyn J. Reuland et al. MEDICAL HYPOTHESES
- Altered secretory and neuroprotective function of the choroid plexus in progressive multiple sclerosis
- (2020) Sabela Rodríguez-Lorenzo et al. Acta Neuropathologica Communications
- Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome
- (2020) Hekmat B. Khoukaz et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Novel oral plasminogen activator inhibitor‑1 inhibitor TM5275 attenuates hepatic fibrosis under metabolic syndrome via suppression of activated hepatic stellate cells in rats
- (2020) Ryuichi Noguchi et al. Molecular Medicine Reports
- Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity
- (2020) Machteld Sillen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- An inflammatory cytokine signature predicts COVID-19 severity and survival
- (2020) Diane Marie Del Valle et al. NATURE MEDICINE
- IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome
- (2020) Sujin Kang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The haemostatic profile in critically ill COVID-19 patients receiving therapeutic anticoagulant therapy
- (2020) Argirios E. Tsantes et al. MEDICINE
- Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition
- (2020) Machteld Sillen et al. Frontiers in Cardiovascular Medicine
- Association of uPA and PAI-1 tumor levels and 4G/5G variants of PAI-1 gene with disease outcome in luminal HER2-negative node-negative breast cancer patients treated with adjuvant endocrine therapy
- (2019) Marko Jevrić et al. BMC CANCER
- The plasminogen activator inhibitor-1 paradox in cancer: a mechanistic understanding
- (2019) Marta Helena Kubala et al. CANCER AND METASTASIS REVIEWS
- Functional plasminogen activator inhibitor 1 is retained on the activated platelet membrane following platelet activation
- (2019) Gael B. Morrow et al. HAEMATOLOGICA
- Plasminogen Activator Inhibitor-1 Level Correlates with Lipoprotein Subfractions in Obese Nondiabetic Subjects
- (2018) Sándor Somodi et al. International Journal of Endocrinology
- Role of plasminogen activator inhibitor‑1 in the diagnosis and prognosis of patients with Parkinson's disease
- (2018) Hong Pan et al. Experimental and Therapeutic Medicine
- Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications
- (2018) Niaz Mahmood et al. Frontiers in Oncology
- A low-glycemic-index diet reduces plasma plasminogen activator inhibitor-1 activity, but not tissue inhibitor of proteinases-1 or plasminogen activator inhibitor-1 protein, in overweight women
- (2018) Lotte Jensen et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Plasminogen activator inhibitor‑1 serves an important role in radiation‑induced pulmonary fibrosis
- (2018) Sachiko Shioya et al. Experimental and Therapeutic Medicine
- PAI-1 Exacerbates White Adipose Tissue Dysfunction and Metabolic Dysregulation in High Fat Diet-Induced Obesity
- (2018) Lin Wang et al. Frontiers in Pharmacology
- Amyloid beta soluble forms and plasminogen activation system in Alzheimer’s disease: Consequences on extracellular maturation of brain-derived neurotrophic factor and therapeutic implications
- (2018) Francesco Angelucci et al. CNS Neuroscience & Therapeutics
- Plasminogen Activator Inhibitor Type-1 as a Regulator of Fibrosis
- (2017) Reyhaneh Rabieian et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- PAI-1 levels are related to insulin resistance and carotid atherosclerosis in subjects with familial combined hyperlipidemia
- (2017) Arturo Carratala et al. JOURNAL OF INVESTIGATIVE MEDICINE
- Fibrinolysis inhibitors in plaque stability: a morphological association of PAI-1 and TAFI in advanced carotid plaque
- (2017) A.-C. Jönsson Rylander et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Association of MMP-2, RB and PAI-1 with decreased recurrence-free survival and overall survival in bladder cancer patients
- (2017) Owen T.M. Chan et al. Oncotarget
- Plasminogen activator inhibitor-1 is an independent prognostic factor of ovarian cancer and IMD-4482, a novel plasminogen activator inhibitor-1 inhibitor, inhibits ovarian cancer peritoneal dissemination
- (2017) Erika Nakatsuka et al. Oncotarget
- Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease
- (2017) Ci Song et al. Journal of the American Heart Association
- A null mutation in SERPINE1 protects against biological aging in humans
- (2017) Sadiya S. Khan et al. Science Advances
- Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses
- (2016) Servet Özcan et al. Aging-US
- The vitronectin RGD motif regulates TGF-β-induced alveolar epithelial cell apoptosis
- (2016) Amanda K. Wheaton et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance
- (2016) P. G. W. Gettins et al. BIOCHEMICAL JOURNAL
- Validated biomarkers: The key to precision treatment in patients with breast cancer
- (2016) Michael J. Duffy et al. BREAST
- Plasminogen activator inhibitor and the risk of cardiovascular disease: The Framingham Heart Study
- (2016) G.H. Tofler et al. THROMBOSIS RESEARCH
- Plasminogen activator inhibitor-1 and type 2 diabetes: a systematic review and meta-analysis of observational studies
- (2016) James Yarmolinsky et al. Scientific Reports
- Resolution of Skin Fibrosis by Neutralization of the Antifibrinolytic Function of Plasminogen Activator Inhibitor 1
- (2016) Raphaël Lemaire et al. Arthritis & Rheumatology
- Small molecules inhibitors of plasminogen activator inhibitor-1 – An overview
- (2015) Anne Rouch et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- The High Affinity Binding Site on Plasminogen Activator Inhibitor-1 (PAI-1) for the Low Density Lipoprotein Receptor-related Protein (LRP1) Is Composed of Four Basic Residues
- (2015) Peter G. W. Gettins et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Plasminogen activator inhibitor-1 as an early potential diagnostic marker for Alzheimer's disease
- (2014) Jaeho Oh et al. EXPERIMENTAL GERONTOLOGY
- Association of the Plasminogen Activator Inhibitor-1 (PAI-1) Gene -675 4G/5G and -844 A/G Promoter Polymorphism with Risk of Keloid in a Chinese Han Population
- (2014) Yang Sun MEDICAL SCIENCE MONITOR
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Structural Insight into Inactivation of Plasminogen Activator Inhibitor-1 by a Small-Molecule Antagonist
- (2013) Zhonghui Lin et al. CHEMISTRY & BIOLOGY
- Plasminogen activator inhibitor-1 inhibitors: a patent review (2006 – present)
- (2013) Yolanda M Fortenberry EXPERT OPINION ON THERAPEUTIC PATENTS
- Plasminogen activator inhibitor-1 in kidney pathology
- (2013) SYLWIA MAŁGORZEWICZ et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1
- (2013) S.-H. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Three Decades of Research on Plasminogen Activator Inhibitor-1: A Multifaceted Serpin
- (2013) Ann Gils et al. SEMINARS IN THROMBOSIS AND HEMOSTASIS
- Vitronectin Inhibits Neutrophil Apoptosis through Activation of Integrin-Associated Signaling Pathways
- (2012) Hong-Beom Bae et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- A peptide mimicking the C-terminal part of the reactive center loop induces the transition to the latent form of plasminogen activator inhibitor type-1
- (2012) Salvino D'Amico et al. FEBS LETTERS
- Characterization of a Small Molecule Inhibitor of Plasminogen Activator Inhibitor Type 1 That Accelerates the Transition into the Latent Conformation
- (2012) Ola Fjellström et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The acute respiratory distress syndrome
- (2012) Michael A. Matthay et al. JOURNAL OF CLINICAL INVESTIGATION
- Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity
- (2012) Hyejin Jeon et al. Journal of Neuroinflammation
- Protumorigenic Activity of Plasminogen Activator Inhibitor-1 Through an Antiapoptotic Function
- (2012) Hua Fang et al. JNCI-Journal of the National Cancer Institute
- Plasminogen activator inhibitor type I may contribute to transient, non-specific changes in immunity in the subacute phase of murine tuberculosis
- (2012) Liesbeth M. Kager et al. MICROBES AND INFECTION
- Therapeutic Value of Small Molecule Inhibitor to Plasminogen Activator Inhibitor–1 for Lung Fibrosis
- (2011) Wen-Tan Huang et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Critical role of type 1 plasminogen activator inhibitor (PAI-1) in early host defense against nontypeable Haemophilus influenzae (NTHi) infection
- (2011) Jae Hyang Lim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice
- (2011) A. J. Courey et al. BLOOD
- Effects of Altered Plasminogen Activator Inhibitor-1 Expression on Cardiovascular Disease
- (2011) Victoria A. Ploplis CURRENT DRUG TARGETS
- Crystal Structure of Plasminogen Activator Inhibitor-1 in an Active Conformation with Normal Thermodynamic Stability
- (2011) Jan K. Jensen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PAI-1 in tissue fibrosis
- (2011) Asish K. Ghosh et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Platelets Retain High Levels of Active Plasminogen Activator Inhibitor 1
- (2011) Helén Brogren et al. PLoS One
- PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in mice
- (2011) A. Goolaerts et al. THORAX
- Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1
- (2010) M. E. Meltzer et al. BLOOD
- Prognostic impact of plasminogen activator inhibitor type 1 expression in bladder cancer
- (2010) Markus Becker et al. CANCER
- Metals affect the structure and activity of human plasminogen activator inhibitor-1. I. Modulation of stability and protease inhibition
- (2010) Lawrence C. Thompson et al. PROTEIN SCIENCE
- Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis
- (2010) T. Senoo et al. THORAX
- Type 1 plasminogen activator inhibitor (PAI-1) in clear cell renal cell carcinoma (CCRCC) and its impact on angiogenesis, progression and patient survival after radical nephrectomy
- (2010) Dragomir P Zubac et al. BMC Urology
- Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture
- (2009) Z. Xu et al. BLOOD
- Plasminogen Activator Inhibitor-1 Regulates Integrin αvβ3 Expression and Autocrine Transforming Growth Factor β Signaling
- (2009) Benjamin S. Pedroja et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients
- (2008) Canan Ersoy et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- High quality structure of cleaved PAI-1-stab
- (2008) M. Dewilde et al. JOURNAL OF STRUCTURAL BIOLOGY
- A Peptide Accelerating the Conversion of Plasminogen Activator Inhibitor-1 to an Inactive Latent State
- (2008) L. Mathiasen et al. MOLECULAR PHARMACOLOGY
- Enhanced clearance of A in brain by sustaining the plasmin proteolysis cascade
- (2008) J. S. Jacobsen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anti-apoptotic roles of plasminogen activator inhibitor-1 as a neurotrophic factor in the central nervous system
- (2008) Satoru Koyanagi et al. THROMBOSIS AND HAEMOSTASIS
- Plasminogen activator inhibitor-1: The double-edged sword in apoptosis
- (2008) Rashna D. Balsara et al. THROMBOSIS AND HAEMOSTASIS
- Oxidative Stress, Plasminogen Activator Inhibitor 1, and Lung Fibrosis
- (2007) Rui-Ming Liu ANTIOXIDANTS & REDOX SIGNALING
- High glucose induces plasminogen activator inhibitor-1 expression through Rho/Rho-kinase-mediated NF-κB activation in bovine aortic endothelial cells
- (2007) Hitoshi Iwasaki et al. ATHEROSCLEROSIS
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started