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Structural characterization and α-glycosidase inhibitory activity of a novel polysaccharide fraction from Aconitum coreanum

CARBOHYDRATE POLYMERS (2020)

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CARBOHYDRATE POLYMERS
卷 230, 期 -, 页码 -

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ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.115586

关键词

A. coreanum polysaccharides (ACPP); Characterization; alpha-Glycosidase

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Chemistry, Applied Chemistry, Organic Polymer Science

资金

  1. National Natural Science Foundation of China [81872952]
  2. Natural Science Foundation of Zhejiang Province [LY18C020006]
  3. Innovation Team of Plant Chemical Industry in Jilin Province [20130521022JH]
  4. Project of Jilin Provincial Department of Education [JJKH20180351KJ]

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alpha-Glycosidase is an essential target for the management of postprandial serum glucose in diabetic patients. Therefore, the interest has been growing in the screening of alpha-glycosidase inhibitor from natural resource. In the present study, the structure and alpha-glycosidase inhibitory activity of a polysaccharide (named as ACPP-1) from Aconitum coreanum were investigated. Based on the results from high performance gel permeation chromatography, GC-MS and 1D/2D nuclear magnetic resonance spectroscopy, ACPP-1 was a highly-linear polysaccharide with a molecular weight of 34.0 kD and containing over 90 % of glucose. It was composed of (1 -> 4)-alpha-D-Glcp and alpha-Aral. ACPP-1 exhibited a dose-dependent inhibitory effect against alpha-glycosidase activity in vitro and the IC(50 )value was similar to 0.8 mg/mL. In oral starch tolerance test, treatment with ACPP-1 (800 mg/kg) significantly improved the starch tolerance in mice. Taken together, this study provided a potential intervention and management for postprandial hyperglycemia by the polysaccharide fraction from A. coreanum.

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