Article
Oncology
Yida Zhang, Lile He, Ananthan Sadagopan, Tao Ma, Gianpietro Dotti, Yufeng Wang, Hui Zheng, Xin Gao, Dian Wang, Albert B. DeLeo, Song Fan, Ruochuan Sun, Ling Yu, Liyuan Zhang, Gongxian Wang, Soldano Ferrone, Xinhui Wang
Summary: FIR significantly upregulates B7-H3 expression on RT-resistant PCSCs and bulk cells, leading to potent cytotoxicity of B7-H3 CAR T cells to FIR-treated PCSCs, and significantly improved antitumor efficacy in mice.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Oncology
Takuya Owari, Nobumichi Tanaka, Yasushi Nakai, Makito Miyake, Satoshi Anai, Shingo Kishi, Shiori Mori, Rina Fujiwara-Tani, Yudai Hojo, Takuya Mori, Masaomi Kuwada, Tomomi Fujii, Masatoshi Hasegawa, Kiyohide Fujimoto, Hiroki Kuniyasu
Summary: 5-ALA can enhance intra-mitochondrial ROS production, increasing sensitivity of prostate cancer cells to radiation therapy. Combined use of 5-ALA and radiation therapy under hypoxic conditions can reduce cancer stemness and radiation resistance.
BRITISH JOURNAL OF CANCER
(2022)
Article
Chemistry, Multidisciplinary
Yukiya Takayama, Kosuke Kusamori, Chihiro Tsukimori, Yosuke Shimizu, Mika Hayashi, Ikumi Kiyama, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto, Makiya Nishikawa
Summary: In this study, MSCs were modified with DOX-Lips to efficiently deliver doxorubicin to tumor cells, demonstrating significant tumor growth inhibition in murine models. The results suggest that DOX-Lip-modified MSCs could serve as an effective carrier system for targeted tumor therapy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Editorial Material
Cell Biology
Anna Mukha, Ugur Kahya, Anna Dubrovska
Summary: Prostate cancer's resistance to radiotherapy is a major hurdle in treatment efficacy, with mechanisms driving tumor cell survival and molecular prognostic markers lacking comprehensive understanding.
Article
Medicine, Research & Experimental
Anna Mukha, Ugur Kahya, Annett Linge, Oleg Chen, Steffen Loeck, Vasyl Lukiyanchuk, Susan Richter, Tiago C. Alves, Mirko Peitzsch, Vladyslav Telychko, Sergej Skvortsov, Giulia Negro, Bertram Aschenbrenner, Ira-Ida Skvortsova, Peter Mirtschink, Fabian Lohaus, Tobias Hoelscher, Hans Neubauer, Mahdi Rivandi, Vera Labitzky, Tobias Lange, Andre Franken, Bianca Behrens, Nikolas H. Stoecklein, Marieta Toma, Ulrich Sommer, Sebastian Zschaeck, Maximilian Rehm, Graeme Eisenhofer, Christian Schwager, Amir Abdollahi, Christer Groeben, Leoni A. Kunz-Schughartlfi, Gustavo B. Baretton, Michael Baumann, Mechthild Krause, Claudia Peitzsch, Anna Dubrovska
Summary: Radiotherapy is an effective treatment for localized prostate cancer due to its ability to induce oxidative stress and DNA damage in tumor cells. However, resistance mechanisms and normal tissue toxicity can limit its effectiveness. Metabolic reprogramming plays a role in therapy resistance, with glutamine metabolism identified as a potential biomarker and therapeutic target for sensitizing prostate cancer to radiotherapy. Inhibiting glutamine catabolism can sensitize cancer cells while sparing nonmalignant cells, and targeting this pathway may also reduce cancer stem cell populations and enhance the effectiveness of radiation therapy.
Article
Chemistry, Multidisciplinary
Qian Wang, Hongmei Cao, Xiaoxue Hou, Dianyu Wang, Zhilong Wang, Yue Shang, Shuqin Zhang, Jinjian Liu, Chunhua Ren, Jianfeng Liu
Summary: This study reports a CAIX-targeted induced in situ self-assembly system on the surface of hypoxic cancer stem-like cells (CSCs), which relieves the hypoxic and acidic microenvironment and promotes CSC differentiation to overcome tumor radiotherapy resistance. The constructed peptide-based drug delivery system exhibits deep penetration, amplified CAIX inhibition, and enhanced cellular uptake, showing potential as a universal treatment strategy for overcoming tumor radioresistance.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Qian Wang, Hongmei Cao, Xiaoxue Hou, Dianyu Wang, Zhilong Wang, Yue Shang, Shuqin Zhang, Jinjian Liu, Chunhua Ren, Jianfeng Liu
Summary: A surface-induced self-assembly system (CA-Pt) is developed to overcome hypoxic cancer stem cell-mediated radioresistance by deep penetration, amplified CAIX inhibition, and enhanced cellular uptake. It effectively relieves the hypoxic and acidic microenvironment, promotes the differentiation of hypoxic CSCs, and enhances the DNA damage induced by radiotherapy. This study provides a universal treatment strategy for overcoming tumor radioresistance.
ADVANCED MATERIALS
(2023)
Review
Oncology
Isis Wolf, Christian Gratzke, Philipp Wolf
Summary: Despite research and improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. Recent findings have highlighted the role of PC stem cells (PCSCs) in tumorigenesis, relapse, metastasis, and treatment resistance. This review discusses the impact of PCSCs in clinical practice and presents new therapeutic approaches to improve outcomes for PC patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biology
Francesco Pasqualetti, Mario Miniati, Alessandra Gonnelli, Giovanni Gadducci, Noemi Giannini, Laura Palagini, Maricia Mancino, Taiusha Fuentes, Fabiola Paiar
Summary: Glioblastoma is highly resistant to radiotherapy. Cancer stem cells play an important role in the growth and resistance of GB. The radiosensitivity of stem cells and biomarkers of stemness are crucial in this field.
Article
Biochemistry & Molecular Biology
Maria T. Loeblein, Isabel Falke, Hans Theodor Eich, Burkhard Greve, Martin Goette, Fabian M. Troschel
Summary: Translation:
In ovarian cancer, targeting Musashi RNA-binding proteins (MSI) may increase therapeutic efficacy by affecting CSC and cell cycle gene expression, metabolic activity, and chemo- and radioresistance. Database analyses revealed associations between MSI proteins and key genes, supporting the potential of MSI dual knockdown to impede tumor growth and sensitize cancer cells to therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Kuo-Shyang Jeng, Chiung-Fang Chang, I-Shyang Sheen, Chi-Juei Jeng, Chih-Hsuan Wang
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. Cancer stem cells (CSCs) in HCC play essential roles in tumor progression, resistance to therapy, and metastasis. Several surface markers, including EpCAM, CD90, CD44, and CD133, are used to identify liver CSCs, and multiple molecular signaling pathways, such as Wnt/beta-catenin, TGF-beta, SHH, PI3K/Akt/mTOR, and Notch, are implicated. Different markers are associated with poor prognosis, advanced tumor stages, early metastasis, and increased recurrence rate. Targeting CSCs and reducing their population is crucial for improving the treatment of advanced HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Igor Karp, Alex Lyakhovich
Summary: Traditional cancer treatments kill differentiated cancer cells but not resistant cells or cancer stem cells, which often cause metastasis and recurrences. Unlike many cancers, the bioenergetics of resistant cells and stem cells are often dependent on mitochondrial function. Compounds that induce mitochondrial dysfunction may provide an alternative approach to anticancer therapy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Oncology
Jakob Pueschel, Anna Dubrovska, Ielizaveta Gorodetska
Summary: Cancer stem cells are the engine of tumor progression and a source of tumor regrowth after treatment. Targeting CSCs might be a powerful tool to overcome tumor resistance and increase the efficiency of current cancer treatment strategies, with high ALDH activity being a common marker of prostate CSCs.
Article
Biochemistry & Molecular Biology
Yu-An Chen, Yi-Ru Lai, Hui-Yu Wu, Yen-Ju Lo, Yu-Fang Chang, Chiu-Lien Hung, Chun-Jung Lin, U-Ging Lo, Ho Lin, Jer-Tsong Hsieh, Cheng-Hsun Chiu, Yu-Hsin Lin, Chih-Ho Lai
Summary: The study identified HA-CdtB-NPs as a promising targeted therapy against radioresistant PCa cells, enhancing DNA double-strand breaks and inducing cell-cycle arrest to increase cell sensitivity. These nanoparticles demonstrate maximum target specificity and delivery efficiency, enhancing the radiation effect in radioresistant PCa cells. Their target specificity and radiomimetic activity suggest that they could be developed as an effective strategy against radioresistant PCa.
Review
Biochemistry & Molecular Biology
Maryam Ghanbari-Movahed, Sahar Shafiee, Jack T. Burcher, Ricardo Lagoa, Mohammad Hosein Farzaei, Anupam Bishayee
Summary: It has been found that cancer stem cells exhibit altered metabolism compared to non-CSCs, which plays a crucial role in tumor initiation, progression, immunosuppression, and resistance to conventional therapy. Two natural flavonoids, apigenin and isovitexin, have been shown to enhance the efficacy of conventional chemotherapeutic drugs by sensitizing CSCs. This study aims to critically evaluate the potential of apigenin and isovitexin in targeting CSCs in different cancers as novel therapeutic agents.
Article
Oncology
Xupeng Bai, Jie Ni, Julia Beretov, Peter Graham, Yong Li
Summary: TNBC shows higher response rate to systemic therapy but poorer tumor differentiation, with higher tendency to metastasis and recurrence. Relapsed and metastatic TNBCs progress more rapidly, demonstrating strong resistance to chemotherapy and radiotherapy.
Article
Engineering, Multidisciplinary
Guangli Zhou, Yongming Yao, Huiying Liu, Xupeng Bai, Jianbo Liu
Summary: The paper presents a strategy for accurate trajectory tracking control of a quadrotor by combining linear prediction model of disturbances and fuzzy sliding mode control based on LFSC. The proposed LFSC scheme showed superior performance and robustness in the presence of external disturbances, as demonstrated through simulation results and comprehensive comparisons.
MATHEMATICAL PROBLEMS IN ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Xupeng Bai, Jie Ni, Julia Beretov, Valerie C. Wasinger, Shanping Wang, Ying Zhu, Peter Graham, Yong Li
Summary: Triple-negative breast cancer (TNBC) is the most aggressive subtype, and radiotherapy is an effective treatment option. However, acquired radioresistance is a major challenge. The integrated stress response (ISR) pathway is found to be highly activated in radioresistant TNBC cells, with the eIF2 alpha /ATF4 axis proposed as a potential therapeutic target.
Review
Cell Biology
Zhenyu Nie, Mei Chen, Xiaohong Wen, Yuanhui Gao, Denggao Huang, Hui Cao, Yanling Peng, Na Guo, Jie Ni, Shufang Zhang
Summary: Bladder cancer is a common malignant tumor of the urinary system, and research related to tumor microenvironment and endoplasmic reticulum stress is crucial for improving treatment outcomes. The challenge lies in overcoming therapeutic resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Wanjia Tian, Ningjing Lei, Junying Zhou, Mengyu Chen, Ruixia Guo, Bo Qin, Yong Li, Lei Chang
Summary: Chemoresistance and metastasis are major challenges in the treatment of ovarian cancer. Understanding the mechanisms of ovarian cancer progression and metastasis is crucial for developing new therapies. Extracellular vesicles (EVs) have recently gained extensive attention due to their role in tumor progression, recurrence, and immune evasion in ovarian cancer.
CELL DEATH & DISEASE
(2022)
Article
Chemistry, Multidisciplinary
Ji Tu, Wentian Li, Sidong Yang, Pengyi Yang, Qi Yan, Shenyu Wang, Kaitao Lai, Xupeng Bai, Cenhao Wu, Wenyuan Ding, Justin Cooper-White, Ashish Diwan, Cao Yang, Huilin Yang, Jun Zou
Summary: This study provides a comprehensive single-cell resolution transcript landscape of human NP, identifying six novel NPC populations with distinct molecular signatures and analyzing their potential functional differences. The study explores predictive transcripts, transcriptional factors, and signal pathways related to degeneration grades. The research reveals that G-MDSCs are enriched in mildly degenerated NP tissues and have immunosuppressive function and alleviation effects on NPC matrix degradation.
Article
Oncology
Yujin Lee, Peter Graham, Yong Li
Summary: Breast cancer lacks effective management approaches for metastasis and therapy-resistant disease. Extracellular vesicles (EVs) play an important role in intercellular communication and are associated with pathological conditions. Cancer cells secrete EVs and communicate with neighboring cells in the tumor microenvironment, which contributes to BC metastasis, immune escape, and chemo-resistance. EVs have emerged as potential therapeutic targets and carriers for BC treatment, stimulating angiogenesis, inhibiting the immune response, and promoting cancer metastasis.
Correction
Pharmacology & Pharmacy
Xupeng Bai, Weipeng Hong, Peiheng Cai, Yibei Chen, Chuncao Xu, Di Cao, Weibang Yu, Zhongxiang Zhao, Min Huang, Jing Jin
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wang Yin, Cuong Pham, Tao Wang, Hadi Al Shamaileh, Rocky Chowdhury, Shweta Patel, Yong Li, Lingxue Kong, Yingchu Hou, Yimin Zhu, Sunrui Chen, Huo Xu, Lee Jia, Wei Duan, Dongxi Xiang
Summary: This study aimed to overcome drug resistance in liver cancer caused by cancer stem cells by using a CD133 aptamer for targeted delivery of Doxorubicin and enhancing the treatment efficacy through autophagy inhibition. The results showed that CD133 aptamer-guided delivery of Doxorubicin resulted in a higher concentration of Doxorubicin in liver cancer stem cells. The combinatorial treatment strategy of CD133 aptamer-Doxorubicin conjugates and an autophagy inhibitor showed a significantly higher elimination of liver cancer stem cells in vitro.
Article
Biochemistry & Molecular Biology
Yujin Lee, Jie Ni, Valerie C. Wasinger, Peter Graham, Yong Li
Summary: This study aimed to optimize the isolation and proteomic analysis methods of sEVs to identify potential protein biomarkers for breast cancer diagnosis. The results showed that the assessment of both the quantity and quality of isolation methods is important in selecting the optimal approach for specific sEV research purposes, depending on the sample types and downstream analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Urology & Nephrology
Athos Katelaris, Ashan Canagasingham, Jie Ni, Nandan Deshpande, David Malouf, Joseph Bucci, James Thompson, Xupeng Bai, Bairen Pang, Ying Zhu, Marc Wilkins, Peter Graham, Yong Li
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
