l-Lysine suppresses myofibrillar protein degradation and autophagy in skeletal muscles of senescence-accelerated mouse prone 8

High mTORC1 signaling is maintained, while protein degradation pathways are perturbed in old murine skeletal muscles in the fasted state

(2016) Zoe White et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Effects of long-term resveratrol-induced SIRT1 activation on insulin and apoptotic signalling in aged skeletal muscle

(2015) Thomas K. Sin et al.   ACTA DIABETOLOGICA

Aging related ER stress is not responsible for anabolic resistance in mouse skeletal muscle

(2015) Sreeda Chalil et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Muscle-specificity of age-related changes in markers of autophagy and sphingolipid metabolism

(2015) David W. Russ et al.   BIOGERONTOLOGY

Testosterone enables growth and hypertrophy in fusion impaired myoblasts that display myotube atrophy: deciphering the role of androgen and IGF-I receptors 

(2015) David C. Hughes et al.   BIOGERONTOLOGY

Muscle mass, structural and functional investigations of senescence-accelerated mouse P8 (SAMP8)

(2015) Guo An Yun et al.   EXPERIMENTAL ANIMALS

Dietary l-Lysine Suppresses Autophagic Proteolysis and Stimulates Akt/mTOR Signaling in the Skeletal Muscle of Rats Fed a Low-Protein Diet

(2015) Tomonori Sato et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dietary (−)-Epigallocatechin-3-gallate Supplementation Counteracts Aging-Associated Skeletal Muscle Insulin Resistance and Fatty Liver in Senescence-Accelerated Mouse

(2015) Hung-Wen Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Autophagy as a Potential Target for Sarcopenia

(2015) Jingjing Fan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Age related skeletal muscle atrophy and upregulation of autophagy in dogs

(2015) Teresa B. Pagano et al.   VETERINARY JOURNAL

p62/SQSTM1 but not LC3 is accumulated in sarcopenic muscle of mice

(2015) Kunihiro Sakuma et al.   Journal of Cachexia Sarcopenia and Muscle

Electroacupuncture Upregulates SIRT1-Dependent PGC-1α Expression in SAMP8 Mice

(2015) Weiguo Dong et al.   MEDICAL SCIENCE MONITOR

Metabolomic Analysis of the Skeletal Muscle of Mice Overexpressing PGC-1α

(2015) Yukino Hatazawa et al.   PLoS One

Diversity of amino acid signaling pathways on autophagy regulation: A novel pathway for arginine

(2014) Aileen B. Angcajas et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Skeletal Muscle Protein Degradation and Synthesis by Oral Administration of Lysine in Rats

(2014) Tomonori SATO et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Lysine suppresses myofibrillar protein degradation by regulating the autophagic-lysosomal system through phosphorylation of Akt in C2C12 cells

(2014) Tomonori Sato et al.   SpringerPlus

Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway

(2013) M. Sandri et al.   BIOGERONTOLOGY

The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals

(2012) Anna-Maria Joseph et al.   AGING CELL

Sarcopenic obesity: A Critical appraisal of the current evidence

(2012) C.M.M. Prado et al.   CLINICAL NUTRITION

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Reduction in Reactive Oxygen Species Production by Mitochondria From Elderly Subjects With Normal and Impaired Glucose Tolerance

(2011) S. Ghosh et al.   DIABETES

The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy

(2011) Victoria C. Foletta et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People

(2010) A. J. Cruz-Jentoft et al.   AGE AND AGEING

Sarcopenia: characteristics, mechanisms and functional significance

(2010) M. V. Narici et al.   BRITISH MEDICAL BULLETIN

Physiological significance of selective degradation of p62 by autophagy

(2010) Masaaki Komatsu et al.   FEBS LETTERS

Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway

(2010) Mikael Altun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Increased muscle PGC-1  expression protects from sarcopenia and metabolic disease during aging

(2009) T. Wenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of muscle protein degradation, not synthesis, by dietary leucine in rats fed a protein-deficient diet

(2008) Takayuki Sugawara et al.   AMINO ACIDS

Effect of amino acid supplementation on muscle mass, strength and physical function in elderly

(2008) Elisabet Børsheim et al.   CLINICAL NUTRITION

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL