Constrained Peptides with Fine-Tuned Flexibility Inhibit NF-Y Transcription Factor Assembly

Foldamer Tertiary Structure through Sequence-Guided Protein Backbone Alteration

(2018) Kelly L. George et al.   ACCOUNTS OF CHEMICAL RESEARCH

Rigid Peptide Macrocycles from On-Resin Glaser Stapling

(2018) Philip A. Cistrone et al.   CHEMBIOCHEM

Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein–Protein Interactions

(2017) Dennis M. Krüger et al.   JOURNAL OF MEDICINAL CHEMISTRY

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(2017) Claire M. Grison et al.   Chemical Science

Challenges in Targeting a Basic Helix–Loop–Helix Transcription Factor with Hydrocarbon-Stapled Peptides

(2016) Amanda L. Edwards et al.   ACS Chemical Biology

Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains

(2016) Raheleh Rezaei Araghi et al.   ACS Chemical Biology

Hydrocarbon constrained peptides – understanding preorganisation and binding affinity

(2016) Jennifer A. Miles et al.   Chemical Science

Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides

(2016) Philipp M. Cromm et al.   Nature Communications

Hydrocarbon Stapled Peptides as Modulators of Biological Function

(2015) Philipp M. Cromm et al.   ACS Chemical Biology

A Thiol-Ene Coupling Approach to Native Peptide Stapling and Macrocyclization

(2015) Yuanxiang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes

(2015) Marta Pelay-Gimeno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acetone-Linked Peptides: A Convergent Approach for Peptide Macrocyclization and Labeling

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Encoded libraries of chemically modified peptides

(2015) Christian Heinis et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Peptide/Protein Stapling and Unstapling: Introduction of s-Tetrazine, Photochemical Release, and Regeneration of the Peptide/Protein

(2015) Stephen P. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics

(2015) V. H. Le et al.   NATURAL PRODUCT REPORTS

Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein–Helix Interaction

(2014) Christopher H. Douse et al.   ACS Chemical Biology

Selection-Based Discovery of Druglike Macrocyclic Peptides

(2014) Toby Passioura et al.   Annual Review of Biochemistry

Indirubin derivatives alter DNA binding activity of the transcription factor NF-Y and inhibit MDR1 gene promoter

(2014) Toru Tanaka et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sequence-Specific Transcription Factor NF-Y Displays Histone-like DNA Binding and H2B-like Ubiquitination

(2013) Marco Nardini et al.   CELL

Targeting the Y/CCAAT box in cancer: YB-1 (YBX1) or NF-Y?

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A Perfluoroaryl-Cysteine SNAr Chemistry Approach to Unprotected Peptide Stapling

(2013) Alexander M. Spokoyny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Development of α-Helical Calpain Probes by Mimicking a Natural Protein–Protein Interaction

(2012) Hyunil Jo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted Disruption of the BCL9/ -Catenin Complex Inhibits Oncogenic Wnt Signaling

(2012) K. Takada et al.   Science Translational Medicine

DNA Minor Groove Sensing and Widening by the CCAAT-Binding Complex

(2012) Eva M. Huber et al.   STRUCTURE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction

(2011) Steven A. Kawamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Assessing Helical Protein Interfaces for Inhibitor Design

(2011) Brooke N. Bullock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and Structure of Stapled Peptides Binding to Estrogen Receptors

(2011) Chris Phillips et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An orthosteric inhibitor of the Ras-Sos interaction

(2011) Anupam Patgiri et al.   Nature Chemical Biology

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

(2011) Young-Woo Kim et al.   Nature Protocols

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

(2010) R. S. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE