Article
Cell Biology
Xiaoxi Zhang, Yunxia Sun, Siyao Cheng, Yanjing Yao, Xintao Hua, Yueyue Shi, Xiaoqin Jin, Jieli Pan, Miaofen G. Hu, Pian Ying, Xiaoli Hou, Daozong Xia
Summary: Cervical carcinoma, characterized by dysregulation of cell cycle, is a leading malignant tumor among women worldwide. The role of Cyclin-dependent kinase 6 (CDK6) in cervical cancer remains controversial. This study found that loss of CDK6 in cervical adenocarcinoma cells inhibited cell proliferation, induced apoptosis and autophagy, and reduced glycolysis and production of biomolecules. Furthermore, CDK6 knockout affected the survival of CDK6-high cervical cancer cells through regulation of glycolysis and autophagy. Inhibition of CDK6 kinase activity could be a potential therapeutic approach for treating cervical cancers.
Article
Biochemistry & Molecular Biology
Lena Berning, David Schluetermann, Annabelle Friedrich, Niklas Berleth, Yadong Sun, Wenxian Wu, Maria Jose Mendiburo, Jana Deitersen, Hannah U. C. Brass, Margaretha A. Skowron, Michele J. Hoffmann, Gunter Niegisch, Joerg Pietruszka, Bjorn Stork
Summary: Prodigiosin has been shown to block autophagy and sensitize cisplatin-resistant cells to apoptotic cell death in urothelial carcinoma cells. It exhibits potent anticancer activity with nanomolar IC50 values and synergistic effects when combined with cisplatin. The effects of prodigiosin are partially mediated by altering lysosomal function, making it a promising candidate for therapy of cisplatin-resistant urothelial carcinomas.
Article
Biochemistry & Molecular Biology
Yuji Nitta, Tomomi Fujii, Tomoko Uchiyama, Aya Sugimoto, Takeshi Nishikawa, Maiko Takeda, Makito Miyake, Keiji Shimada, Kiyohide Fujimoto
Summary: The study reveals the significant role of miR-138-SOX9 signaling in urothelial carcinoma. Targeting SOX9, miR-138 can reduce the proliferation and invasion of urothelial carcinoma cells by promoting autophagy and apoptosis and inducing cell cycle arrest.
Article
Pharmacology & Pharmacy
Mengxin Li, Xuyang Chen, Xuanzhong Wang, Xiaodong Wei, Ding Wang, Xiaorui Liu, Libo Xu, Wuren Batu, Yang Li, Baofeng Guo, Ling Zhang
Summary: The study demonstrated that RSL3 improved the sensitivity of PCa to DDP by causing glycolysis dysfunction, effectively inhibiting PCa cell proliferation both in vitro and in vivo. Additionally, cotreatment of RSL3 and DDP could alleviate apoptosis and cell cycle abnormalities in PCa cells, providing a potential therapeutic strategy for PCa.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Cell Biology
Tammy M. Holm, Syn Yeo, Kevin M. Turner, Jun-Lin Guan
Summary: Autophagy plays a crucial role in thyroid cancer, promoting tumor cell survival and metastasis, while also inhibiting tumor development by maintaining genomic stability. Autophagy inhibitors may enhance the effectiveness of thyroid cancer therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sajid Jalal, Ting Zhang, Jia Deng, Jie Wang, Ting Xu, Tianhua Zhang, Chuanxin Zhai, Ruqiang Yuan, Hongming Teng, Lin Huang
Summary: This study found that LXX-8250 treatment can induce apoptosis in melanoma cells by inhibiting autophagic flux and glycolysis. This effect is mediated by suppression of PFKFB4 expression. The research provides a novel strategy for the treatment of melanoma.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Styliani Papadaki, Angeliki Magklara
Summary: Cancer cells rely on glycolysis for energy production, while cancer stem cells have the ability to switch between glycolysis and oxidative phosphorylation depending on their energy needs and stimuli from the microenvironment, with this metabolic plasticity being associated with therapy resistance.
Article
Pharmacology & Pharmacy
Xiaoyu Yan, Rui Tian, Jicheng Sun, Yuanxin Zhao, Buhan Liu, Jing Su, Minghua Li, Wei Sun, Xuesong Xu
Summary: Sorafenib, as the first FDA-approved drug for the treatment of advanced hepatocellular carcinoma (HCC), has gained much attention. The study found that changes in glucose metabolism induced by sorafenib are the key mechanism of HCC cell resistance. Autophagy, a metabolic-recycling pathway, regulates multiple important pathways involved in cell survival and death. The study showed that inhibition of autophagy can significantly increase the sensitivity of HCC cells to sorafenib and reverse the enhancement of glycolysis. Additionally, sorafenib-induced autophagy promotes HDAC6 activity by degrading p62, which in turn regulates the acetylation of its critical substrate HSP90 and promotes the activity of PKM2.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Elisabetta Panza, Ivana Bello, Martina Smimmo, Vincenzo Brancaleone, Emma Mitidieri, Mariarosaria Bucci, Giuseppe Cirino, Raffaella Sorrentino, Roberta d'Emmanuele di Villa Bianca
Summary: The impairment of the H2S pathway involving CSE and CBS-derived hydrogen sulfide is observed in urothelial carcinoma. Thus, targeting the H2S signaling pathway could be a novel therapeutic strategy for this type of cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biology
Laure Perrin-Cocon, Pierre-Olivier Vidalain, Clemence Jacquemin, Anne Aublin-Gex, Keedrian Olmstead, Baptiste Panthu, Gilles Jeans Philippe Rautureau, Patrice Andre, Piotr Nyczka, Marc-Thorsten Huett, Nivea Amoedo, Rodrigue Rossignol, Fabian Volker Filipp, Vincent Lotteau, Olivier Diaz
Summary: During the transformation into hepatocellular carcinoma, the replacement of GCK by HK2 is associated with poor prognosis for patient survival. Knocking out HK2 and expressing GCK in Huh7 cell line rewired central carbon metabolism, stimulated mitochondrial respiration, and reactivated innate immune responses, showing that consequences of the HK switch extend beyond metabolic reprogramming.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yanhong Wang, Xinyu Mang, Danni Li, Yiliang Chen, Zhenyu Cai, Fei Tan
Summary: In this study, the anti-neoplastic functions and mechanism of Piezo-CAP on hepatocellular carcinoma (HCC) were investigated. The results showed that Piezo-CAP could inhibit cell proliferation, migration and invasion, promote cell apoptosis and autophagy, and disrupt the survival pathways of redox deregulation, glycolysis, and PI3K/AKT/mTOR/HIF-1α signaling. Piezo-CAP has the potential to be a therapeutic approach for HCC.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Oncology
Mike Wenzel, Marina Deuker, Luigi Nocera, Claudia Colla Ruvolo, Zhe Tian, Shahrokh F. Shariat, Fred Saad, Alberto Briganti, Andreas Becker, Luis A. Kluth, Felix K. H. Chun, Pierre Karakiewicz
Summary: Variant histology in urethral cancer is associated with higher cancer specific mortality compared to urothelial histology. Chemotherapy improves survival in metastatic urethral cancer patients with adenocarcinoma and other variant histology, but not in those with squamous cell carcinoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Prakash P. Praharaj, Amruta Singh, Srimanta Patra, Sujit K. Bhutia
Summary: Cancer stem cell populations are enriched by cisplatin treatment through autophagy. Autophagy is essential for maintaining cancer stemness and resistance to cisplatin-induced cytotoxicity. Inhibiting autophagy activates NRF2 signaling, reduces reactive oxygen species, and enhances cancer stemness. Combining autophagy inhibition with NRF2 signaling inhibition can enhance cisplatin cytotoxicity and suppress the expansion of oral CD44+ cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Medicine, Research & Experimental
Maha Al-Tamimi, Abdul Q. Khan, Rasheeda Anver, Fareed Ahmad, Jericha M. Mateo, Syed Shadab Raza, Majid Alam, Joerg Buddenkotte, Martin Steinhoff, Shahab Uddin
Summary: This study explored the underlying mechanisms of pristimerin-induced programmed cell death in squamous cell carcinoma cells. The results showed that pristimerin inhibits the growth and proliferation of cancer cells through JNK activation, and induces cell death via apoptosis and autophagy. Moreover, pristimerin sensitizes cancer cells to conventional anticancer drugs through ROS-mediated JNK activation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Wang Yin, Cuong Pham, Tao Wang, Hadi Al Shamaileh, Rocky Chowdhury, Shweta Patel, Yong Li, Lingxue Kong, Yingchu Hou, Yimin Zhu, Sunrui Chen, Huo Xu, Lee Jia, Wei Duan, Dongxi Xiang
Summary: This study aimed to overcome drug resistance in liver cancer caused by cancer stem cells by using a CD133 aptamer for targeted delivery of Doxorubicin and enhancing the treatment efficacy through autophagy inhibition. The results showed that CD133 aptamer-guided delivery of Doxorubicin resulted in a higher concentration of Doxorubicin in liver cancer stem cells. The combinatorial treatment strategy of CD133 aptamer-Doxorubicin conjugates and an autophagy inhibitor showed a significantly higher elimination of liver cancer stem cells in vitro.
Article
Multidisciplinary Sciences
Vivek Sood, Kajal Kamboj, Prateek Bhatia, Vishal Sharma, Monica Kundu, Arpita Ghosh, Sanjay Kumar Singh, Thakur Sen, Prabhjot Kaur, Raja Ramachandran, Manish Rathi, Harbir Singh Kohli, Krishan Lal Gupta, Samir Malhotra, Ashok Kumar Yadav, Vivek Kumar, Vivekanand Jha
Summary: This study investigated the effects of two dosing regimens of oral iron on iron status and hematological parameters in CKD patients. The results showed no significant difference in TSAT changes between the groups, but the OD group had a smaller increase in serum ferritin and an increase in MCHC compared to the BD group.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Medicine, General & Internal
Gautam Satheesh, M. K. Unnikrishnan, Vivekanand Jha, Abdul Salam
BMJ EVIDENCE-BASED MEDICINE
(2023)
Editorial Material
Urology & Nephrology
Alex Gallagher, Brendan Smyth, Vivekanand Jha
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Review
Urology & Nephrology
Vivek Kumar, Vivekanand Jha
Summary: This review discusses the differences between community acquired acute kidney injury (CA-AKI) and hospital acquired acute kidney injury (HA-AKI), emphasizing the need for different approaches in tackling these conditions. The burden of AKI is higher in low-income countries and CA-AKI is the dominant form in these settings. Current clinical practice guidelines focus more on HA-AKI and fail to fully capture the spectrum and impact of CA-AKI.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2023)
Article
Urology & Nephrology
Kirsten L. Johansen, Alexander R. Cobitz, Ajay K. Singh, Iain C. Macdougall, Renato D. Lopes, Gregorio T. Obrador, Csaba P. Kovesdy, Rubeen Israni, Vivekanand Jha, Tony Okoro, Mike Sprys, Shivinder Jolly, Alistair C. Lindsay, Purav Bhatt, Rodrigo Refoios Camejo, Tom Keeley, Borut Cizman, David C. Wheeler
Summary: The ASCEND-NHQ trial demonstrated that daprodustat significantly increased hemoglobin levels and improved fatigue symptoms in patients with chronic kidney disease stages 3-5. These findings highlight the potential benefits of daprodustat in managing anemia in this patient population.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Michelle A. Josephson, Yolanda Becker, Klemens Budde, Bertram L. Kasiske, Bryce A. Kiberd, Alexandre Loupy, Jolanta Malyszko, Roslyn B. Mannon, Burkhard Toenshoff, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Martin Zeier
Summary: In March 2022, KDIGO held a virtual Controversies Conference to address the often overlooked phase of kidney transplant failure. The conference discussed various aspects related to failing allografts, including prognosis, immunosuppression strategies, management of complications, and choice of treatment options. The conference emphasized the importance of identifying individuals with failing allografts, accurate prognostication tools, psychological preparation and support, and patient involvement in decision-making.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Emma O'Lone, Fred S. Apple, James O. Burton, Fergus J. Caskey, Jonathan C. Craig, Christopher R. deFilippi, Derek Forfang, Karen A. Hicks, Vivekanand Jha, Kenneth W. Mahaffey, Patrick B. Mark, Patrick Rossignol, Nicole Scholes-Robertson, Allison Jaue, Andrea K. Viecelli, Angela Y. Wang, David C. Wheele, David White, Wolfgang C. Winkelmayer, Charles A. Herzog
Summary: Cardiovascular disease is the leading cause of death in hemodialysis patients. However, there is currently no standardized definition of myocardial infarction (MI) for this population. The international working group recommends specific approaches for interpreting ischemic symptoms and performing baseline electrocardiograms to improve the accuracy of MI diagnosis in hemodialysis patients. While baseline cardiac troponin values are not recommended, serial cardiac biomarkers should be obtained when ischemia is suspected.
KIDNEY INTERNATIONAL
(2023)
Editorial Material
Urology & Nephrology
Priyadarshini John, Vivekanand Jha
KIDNEY INTERNATIONAL REPORTS
(2023)
Editorial Material
Urology & Nephrology
Edwina A. Brown, Vivekhand Jha, Steering Comm
KIDNEY INTERNATIONAL REPORTS
(2023)
Review
Medicine, Research & Experimental
Vivekanand Jha, Saeed M. G. Al-Ghamdi, Guisen Li, Mai-Szu Wu, Panagiotis Stafylas, Lise Retat, Joshua Card-Gowers, Salvatore Barone, Claudia Cabrera, Juan Jose Garcia Sanchez
Summary: This review examines the costs of chronic kidney disease (CKD) in 31 countries/regions and provides estimates of CKD management and associated complications. The study finds that CKD imposes a significant economic burden that increases with disease severity, and there are significant gaps and inconsistencies in published cost studies and definitions.
ADVANCES IN THERAPY
(2023)
Article
Medicine, General & Internal
Arpita Ghosh, Monica Kundu, Niveditha Devasenapathy, Mark Woodward, Vivekanand Jha
Summary: This study aimed to examine the prevalence and correlates of frailty in middle-aged and older Indian adults. The results showed that the prevalence of frailty among adults aged 45 and above was 30%, with higher rates in women compared to men. Frail adults had higher odds of hospitalization and falls, as well as poorer cognition.
Article
Economics
Phil McEwan, Marco Hafner, Vivekenand Jha, Ricardo Correa-Rotter, Gil Chernin, Luca De Nicola, Russell Villanueva, David C. Wheeler, Salvatore Barone, Stephen Nolan, Juan Jose Garcia Sanchez
Summary: This study assessed the potential medical care cost offsets associated with dapagliflozin treatment for chronic kidney disease. The results showed that dapagliflozin plus standard therapy can reduce the incidence of cardio-renal outcomes compared to standard therapy alone, leading to a 33% reduction in total costs across 31 countries and regions.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Urology & Nephrology
Vivekanand Jha
INDIAN JOURNAL OF NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
G. F. Senguel, R. Mishra, E. Candiello, P. Schu
Summary: AP2 forms AP2 CCV with clathrin and other coat proteins, and synapses contain different types of CCV. The stability and composition of CCV are regulated by various factors, including Hsc70 and phosphorylation patterns. The knockout of the AP1/O1B complex disrupts synaptic vesicle recycling and endosomal protein sorting, leading to upregulation of endocytosis. Stable CCV, termed stCCV, have distinct characteristics and specialized functions in synaptic plasticity. The phosphorylation of Hsc70 and the levels of kinases play a crucial role in regulating the stability and disassembly of clathrin in CCV.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Martin Fluck, Colline Sanchez, Vincent Jacquemond, Christine Berthier, Marie-Noelle Giraud, Daniel Jacko, Kathe Bersiner, Sebastian Gehlert, Guus Baan, Richard T. Jaspers
Summary: Enhancing CaMKII signaling improves fatigue resistance and contractile characteristics of skeletal muscle by enhancing calcium release.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Letter
Biochemistry & Molecular Biology
Federica Coppola, Sara Monaci, Alessandro Falsini, Carlo Aldinucci, Irene Filippi, Daniela Rossi, Fabio Carraro, Antonella Naldini
Summary: The adaptor protein p62 plays a crucial role in maintaining the survival of dendritic cells (DCs) under hypoxic conditions by preserving Erk1/2 phosphorylation and reducing AMPK activation, thus extending their lifespan to ensure their functions in hypoxic microenvironments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Jenifer Pendiuk Goncalves, Jorvani Cruz Villarreal, Sierra A. Walker, Xuan Ning Sharon Tan, Chad Borges, Joy Wolfram
Summary: This study used a mass spectrometry-based approach to assess the differences in glycan features between extracellular vesicles (EVs) and originating cells. The results showed that EVs selectively enriched specific glycan features, particularly those associated with binding to the extracellular matrix. The study also found differences in EV glycan sorting between different metastatic cell lines and mouse models, indicating a potential role of glycan diversity in the metastatic process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
De-ao Gong, Peng Zhou, Wen-yi Chang, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang, Kai Wang
Summary: Liver cancer, ranked sixth globally, is a major contributor to cancer-related mortality. Metastasis is the main cause of treatment failure and deaths in liver cancer. The SPOP-CREB5-MET axis plays a significant role in liver cancer metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ning Huang, Jun Tang, Xiaoyao Yi, Maoxin Zhang, Bin Li, Yuan Cheng, Jin Chen
Summary: This study reveals that glioma-derived S100A9 can induce microglial M2 polarization, inhibit CD8+ T lymphocytes, and promote immunosuppression. The mechanism is related to the interaction with alpha v133 integrin and subsequent activation of AKT1 in microglia. The expression of S100A9 is positively associated with CD206 expression and negatively correlated with CD8+ T lymphocyte accumulation in the TME, suggesting a potential role of S100A9 in regulating the tumor microenvironment and immune evasion in glioma.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Yomna S. Abd El-Aziz, Matthew J. McKay, Mark P. Molloy, Betty McDowell, Elizabeth Moon, Loretta Sioson, Amy Sheen, Angela Chou, Anthony J. Gill, Patric J. Jansson, Sumit Sahni
Summary: This study identified a novel combination of autophagy inhibitors that can effectively inhibit the proliferation of oral squamous cell carcinoma (OSCC) cells, including both chemosensitive and chemoresistant cells. This research is important for the development of new therapies for advanced OSCC tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Luojia Liu, Xiaoqiang Liu, Ying Chen, Meng Kong, Jinghong Zhang, Min Jiang, Hongling Zhou, Jinrui Yang, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jiaping Zhang
Summary: Our study revealed that the Paxillin/HDAC6 signaling pathway regulates microtubule acetylation in electric field-guided keratinocyte migration.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Julia Weikum, Jeroen F. van Dyck, Saranya Subramani, David P. Klebl, Merete Storflor, Stephen P. Muench, Soren Abel, Frank Sobott, J. Preben Morth
Summary: The study reveals the complex interaction between bacterial magnesium transporter A (MgtA) and cardiolipin 18:1 and cardiolipin 16:0, highlighting the importance of lipid environment in protein activity and stability. Further understanding of Mg2+ homeostasis in bacteria will provide insights into bacterial infections.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Sumit Kinger, Yuvraj Anandrao Jagtap, Ankur Rakesh Dubey, Prashant Kumar, Akash Choudhary, Rohan Dhiman, Vijay Kumar Prajapati, Deepak Chitkara, Krishna Mohan Poluri, Amit Mishra
Summary: Efficient protein synthesis and quality control mechanisms are crucial for maintaining proteostasis and preventing neurodegeneration. This study demonstrates that treating cells with Lanosterol can enhance the proteolytic activity of Proteasome and promote the removal of misfolded proteins, suggesting a potential therapeutic approach for abnormal protein accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Karolina Stepien, Adrianna Skoneczna, Monika Kula-Maximenko, Lukasz Jurczyk, Mateusz Molon
Summary: The replication of DNA requires a complex machinery called the replisome, which is highly conserved across species. One crucial component of the replisome is the CMG helicase complex, which unwinds DNA and coordinates the assembly and function of other replisome components. In this study, the impact of the absence of one copy of the CMG complex genes on the physiology and aging of yeast cells was investigated. The findings showed disruptions in the cell cycle, extended doubling times, and alterations in the biochemical profile of these cells. Importantly, it was found that heterozygous cells for CMG helicase genes exhibited increased reproductive potential and delayed aging. The study also highlighted potential therapeutic targets for cancer treatment using yeast.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Nishadh Rathod, Guadalupe Guerrero-Serna, Howard S. Young, L. Michel Espinoza-Fonseca
Summary: This study reveals that replacing Lys27 with Asn enhances the inhibitory potency of MLN without affecting SERCA's affinity for Ca2+. The findings suggest that the SERCA site modulating Ca2+ affinity also functions as a catalytic activity switch.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Can Jiang, Chunyang Zhang, Min Dai, Fuyan Wang, Sa Xu, Dan Han, Yanyan Wang, Yajie Cao, Yanyan Liang, Ziyu Zhang, Lina Yan, Yujun Shen, Kewu He, Yuxian Shen, Jun Liu
Summary: The phosphorylation of p65 and the expression of SUMO1 are increased in cancer tissues of HCC patients, and there is a positive correlation between SUMO1 and phosphorylated p65. SUMOylation of p65 by SUMO1 promotes p65 nuclear import and enhances NF-xB activity. Both SUMOylation and phosphorylation of p65 increase the viability and invasion of hepatoma cells, and decrease cell apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ming-Fo Hsu, Yoshihiro Ito, Jai Prakash Singh, Shu-Fang Hsu, Alan Wells, Kuang-Yu Jen, Tzu-Ching Meng, Fawaz G. Haj
Summary: This study identified alpha-actinin4 as a novel substrate of PTP1B in podocytes and demonstrated their interaction in regulating podocyte function. Targeting PTP1B and alpha-actinin4 could be a potential therapeutic approach for podocyte injury.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Paulo F. V. Bizerra, Eduardo H. Gilglioni, Hang Lam Li, Simei Go, Ronald P. J. Oude Elferink, Arthur J. Verhoeven, Jung -Chin Chang
Summary: This study investigates the role of cyclic AMP (cAMP) in glycogen metabolism and reveals that cAMP regulates glycogenolysis in opposite directions depending on its site of synthesis within cells and downstream effectors. The canonical tmAC-cAMP-PKA signaling promotes glycogenolysis, while the non-canonical sAC-cAMP-Epac1 signaling suppresses glycogenolysis. This highlights the importance of cAMP microdomain organization for distinct metabolic regulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)