Rap1‐mediated nucleosome displacement can regulate gene expression in senescent cells without impacting the pace of senescence

NAD+ metabolism governs the proinflammatory senescence-associated secretome

(2019) Timothy Nacarelli et al.   NATURE CELL BIOLOGY

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

(2018) Athena Georgilis et al.   CANCER CELL

Systematic Study of Nucleosome-Displacing Factors in Budding Yeast

(2018) Chao Yan et al.   MOLECULAR CELL

Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest

(2018) Przemyslaw Sapieha et al.   TRENDS IN CELL BIOLOGY

Epigenetic Mechanisms Impacting Aging: A Focus on Histone Levels and Telomeres

(2018) Shufei Song et al.   Genes

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

Telomere shortening triggers a feedback loop to enhance end protection

(2017) Chia-Wei Yang et al.   NUCLEIC ACIDS RESEARCH

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance

(2016) Paula Martínez et al.   AGING CELL

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Asymmetric unwrapping of nucleosomal DNA propagates asymmetric opening and dissociation of the histone core

(2016) Yujie Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions

(2016) Rekha Rai et al.   Nature Communications

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

(2016) N. Tasdemir et al.   Cancer Discovery

Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming

(2015) Abdenour Soufi et al.   CELL

Nucleosome Stability Distinguishes Two Different Promoter Types at All Protein-Coding Genes in Yeast

(2015) Slawomir Kubik et al.   MOLECULAR CELL

Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex

(2015) M Daniel Ricketts et al.   Nature Communications

A genomics approach identifies senescence-specific gene expression regulation

(2014) Daniel H. Lackner et al.   AGING CELL

Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging

(2014) Z. Hu et al.   GENES & DEVELOPMENT

Two distinct promoter architectures centered on dynamic nucleosomes control ribosomal protein gene transcription

(2014) Britta Knight et al.   GENES & DEVELOPMENT

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

(2013) Marco De Cecco et al.   AGING CELL

Rif1 and Rif2 Shape Telomere Function and Architecture through Multivalent Rap1 Interactions

(2013) Tianlai Shi et al.   CELL

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

(2013) P. P. Shah et al.   GENES & DEVELOPMENT

Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence

(2013) J. M. Platt et al.   GENES & DEVELOPMENT

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

The 50:50 method for PCR-based seamless genome editing in yeast

(2013) Joe Horecka et al.   YEAST

Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging

(2013) Ling Liu et al.   Cell Reports

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Genome-wide protein–DNA binding dynamics suggest a molecular clutch for transcription factor function

(2012) Colin R. Lickwar et al.   NATURE

The great unravelling: chromatin as a modulator of the aging process

(2012) Roderick J. O'Sullivan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Comprehensive Genome-wide Protein-DNA Interactions Detected at Single-Nucleotide Resolution

(2011) Ho Sung Rhee et al.   CELL

Pioneer transcription factors: establishing competence for gene expression

(2011) K. S. Zaret et al.   GENES & DEVELOPMENT

Characterization of a Highly Conserved Histone Related Protein, Ydl156w, and Its Functional Associations Using Quantitative Proteomic Analyses

(2011) Joshua M. Gilmore et al.   MOLECULAR & CELLULAR PROTEOMICS

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

The orientation of the C-terminal domain of the Saccharomyces cerevisiae Rap1 protein is determined by its binding to DNA

(2011) Béatrice Matot et al.   NUCLEIC ACIDS RESEARCH

Telomere capping in non-dividing yeast cells requires Yku and Rap1

(2010) Momchil D Vodenicharov et al.   EMBO JOURNAL

Chromatin structure as a mediator of aging

(2010) Jason Feser et al.   FEBS LETTERS

Characterization of the Yeast Telomere Nucleoprotein Core

(2010) Tanya L. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide YFP Fluorescence Complementation Screen Identifies New Regulators for Telomere Signaling in Human Cells

(2010) Ok-Hee Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

Elevated Histone Expression Promotes Life Span Extension

(2010) Jason Feser et al.   MOLECULAR CELL

Extensive role of the general regulatory factors, Abf1 and Rap1, in determining genome-wide chromatin structure in budding yeast

(2010) Mythily Ganapathi et al.   NUCLEIC ACIDS RESEARCH

Interaction of Transcriptional Regulators with Specific Nucleosomes across the Saccharomyces Genome

(2009) R. Thomas Koerber et al.   MOLECULAR CELL

Aging by epigenetics—A consequence of chromatin damage?

(2008) John M. Sedivy et al.   EXPERIMENTAL CELL RESEARCH

Acetylation in the globular core of histone H3 on lysine-56 promotes chromatin disassembly during transcriptional activation

(2008) Stephanie K. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA