Article
Fisheries
Yapeng Liu, Hailing Du, Shanghong Wang, Yangfeng Lv, Hang Deng, Kaile Chang, Pengcheng Zhou, Chengyu Hu
Summary: The study reveals that TNK1 plays a crucial role in the JAK-STAT pathway in fish, enhancing the expression of IFN I.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Food Science & Technology
Hoon Kim, Jeong-Ju Lim, Hyun Young Shin, Hyung Joo Suh, Hyeon-Son Choi
Summary: The study demonstrated that the paraprobiotic LAB-P effectively inhibited lipid accumulation in preadipocytes by regulating early adipogenic factors and signaling pathways, suggesting its potential as a functional food material for controlling obesity and related diseases.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Immunology
Xinhuai Dong, Can Lin, Xu Lin, Chong Zeng, Liming Zeng, Zibo Wei, Xiaokang Zeng, Jie Yao
Summary: Lactate reduces the protein level and activation of STAT1 in ovarian cancer cells, weakens the antitumor effect of IFN alpha, and hinders the recruitment of NKT and CD8(+)T cells. Lactate triggers the degradation of STAT1 through the proteasomal pathway by promoting the expression of Fbxo40, which acts as an E3 ubiquitin ligase, resulting in the induction of STAT1 polyubiquitination and degradation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yaoyao Yu, Shengqian Dou, Peng Peng, Li Ma, Xia Qi, Ting Liu, Yang Yu, Chao Wei, Weiyun Shi
Summary: In this study, the deficiency of AIRE in corneas led to the development of corneal plaques and delayed re-epithelialization. Pharmacological blockade of IFN-I/JAK/STAT1 signaling accelerated epithelial wound healing and alleviated corneal plaques and squamous metaplasia.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Microbiology
Elena Riera, Daniel Perez-Nunez, Raquel Garcia-Belmonte, Lisa Miorin, Adolfo Garcia-Sastre, Yolanda Revilla
Summary: Infection with ASFV strains both virulent and attenuated have been shown to prevent interferon-stimulated gene expression in interferon-treated cells by counteracting the JAK/STAT signaling pathway. Two independent mechanisms of control of the JAK/STAT pathway suggest the importance of preventing this pathway for successful viral replication. Understanding these IFN antagonistic properties may lead to new strategies to control ASFV.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Virology
Baisong Zheng, Xiaolei Zhou, Li Tian, Jian Wang, Wenyan Zhang
Summary: This study reveals that EV71 can antagonize the ISG OAS3, which is the major determinant of IFN-beta 1b-mediated inhibition of EV71 replication. OAS3 functions by activating downstream RNase L. EV71 infection induces the expression of OAS3 but not RNase L through the IFN pathway. Mechanistically, EV71 or IFN-beta 1b-induced phosphorylation of STAT1 initiates the transcription of OAS3 by directly binding to its promoter.
Article
Rheumatology
Dongliang Shi, Yan Li, Xiaomei Shi, Meihong Yao, Dan Wu, Yuhui Zheng, Qing Lin, Yinghong Yang
Summary: This study used bioinformatics methods to identify key genes associated with the occurrence and development of LN, and confirmed the importance of CXCL10 and STAT1 in LN. Experimental results showed that IFN-gamma induces the expression of CXCL10 by activating the JAK/STAT1 signaling pathway, while triptolide inhibits the expression of CXCL10 by blocking the JAK/STAT1 signaling pathway. This suggests that inhibition of the JAK/STAT1 signaling pathway and CXCL10 expression may be a potential target for the treatment of LN.
CLINICAL RHEUMATOLOGY
(2023)
Article
Biology
Wenjing You, Shiqi Liu, Jie Li, Yuang Tu, Tizhong Shan
Summary: This study identified GADD45A as a critical regulator in subcutaneous fat deposition and lipid metabolism. GADD45A deficiency induces inguinal white adipose tissue (iWAT) browning and protects mice against HFD-induced obesity. These findings provide new potential targets for combating obesity-related metabolic diseases and improving human health.
Review
Oncology
Fei Xiong, Qi Wang, Guan-hua Wu, Wen-zheng Liu, Bing Wang, Yong-jun Chen
Summary: IFN-alpha 2b is a highly active cytokine that has antiviral, antitumour, antiparasitic, and immunomodulatory activities. Its antiproliferative effects are mainly mediated through the JAK-STAT pathway. Regulators of IFN-alpha 2b function may help improve its therapeutic efficacy.
BIOMARKER RESEARCH
(2022)
Review
Immunology
Qirong Li, Baozhen Sun, Yue Zhuo, Ziping Jiang, Rong Li, Chao Lin, Ye Jin, Yongjian Gao, Dongxu Wang
Summary: Hepatitis B virus (HBV) is a virus that causes acute and chronic hepatitis, as well as liver cancer and cirrhosis. Interferons (IFNs) are proteins with antiviral properties and play an important role in the immune system. IFNs inhibit HBV replication and transcription by inducing the expression of IFN-stimulated genes (ISGs) in host cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Min Qiao, Shanshan Li, Jinfeng Yuan, Weicong Ren, Yuanyuan Shang, Wei Wang, Rongmei Liu, Fuzhen Zhang, Qing Li, Xiao Wu, Jie Lu, Mengqiu Gao, Yu Pang
Summary: This study analyzed the effects of delamanid (DLM), an inhibitor of mycolic acid synthesis, on human macrophages. The results showed that DLM can suppress CXCL10 expression by regulating the JAK2/STAT1 signaling pathway, leading to a reduction in inflammation in multidrug-resistant tuberculosis (MDR-TB) patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Reproductive Biology
Xinyan Zhang, Suhua Gong, Haijing Li, Jiaqi Jiang, Yanni Jia, Ruixue Zhang, Haokun Liu, Aihua Wang, Yaping Jin, Pengfei Lin
Summary: In this study, the role and mechanism of Ubiquitin-specific protease 18 (USP18) on endometrial receptivity in goats were investigated. The results showed that USP18 promotes endometrial receptivity by regulating the JAK/STAT1 pathway and ISGylation. Additionally, the expression levels of USP18 were significantly increased during early pregnancy. Therefore, USP18 may play an important role in goat endometrial receptivity.
Article
Cell Biology
Shuang Shang, Yu-wei Yang, Fei Chen, Liang Yu, Shuo-hao Shen, Ke Li, Bing Cui, Xiao-Xi Lv, Cheng Zhang, Chen Yang, Jing Liu, Jiao-jiao Yu, Xiao-wei Zhang, Ping-ping Li, Sheng-tao Zhu, Hai-zeng Zhang, Fang Hua
Summary: TRIB3 inhibits CD8(+) T cell infiltration in colorectal cancer by inhibiting STAT1 activation and reducing tumor-infiltrating T cells. Acetyltransferase P300 acetylates TRIB3 and prevents its ubiquitination and degradation. Genetic ablation of TRIB3 or pharmacological acceleration of TRIB3 degradation with a P300 inhibitor increases T cell recruitment and sensitizes colorectal cancers to immune checkpoint blockade therapy.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Fei Qi, Fang Liu, Ling Gao
Summary: Vitiligo is a reversible skin disorder characterized by white patches resulting from destruction of melanocytes. JAK inhibitors have shown effectiveness in treating vitiligo by targeting the JAK/STAT pathway, but further studies are needed to determine optimal dosage and identify other inflammatory pathways involved in the pathogenesis of the condition.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yanpeng Li, Haodong Cui, Shipeng Li, Xingyan Li, Hongtao Guo, Kutty Selva Nandakumar, Zhilei Li
Summary: Research has shown that Kaempferol can improve psoriasis and alleviate its skin lesions. It exerts its therapeutic effects by modulating the IFN-gamma-induced JAK-STAT signaling pathway and reducing the number of inflammatory cells. These findings provide a basis for clinical application.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
A. Prabakaran, Amit Alexander
Summary: The molecular interactions and mucoadhesive nature of chitosan-coated liposomes with mucin are crucial for the development of an effective drug delivery system. The positively charged SA-CH-LPs showed stronger interaction and better mucoadhesive properties compared to negatively charged SALPs, thereby improving drug retention in the nasal cavity and enhancing therapeutic efficacy.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Maryam Noei-Khesht Masjedi, Esmaeil Sadroddiny, Jafar Ai, Saeed Balalaie, Yazdan Asgari
Summary: This study discovered an effective strategy for cargo sorting within exosomes by incorporating an appropriate cleavage site, providing further insight into the potential of exosomes as nano-shuttles bearing therapeutic biomolecules.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Pei -Gee Yap, Chee-Yuen Gan
Summary: This study collected the sequences of 128 tyrosinase inhibitory peptides and analyzed their hydrophobicity/hydrophilicity properties and amino acid profiles. Molecular docking analysis was used to investigate the binding interactions between peptides and tyrosinase. The study found that hydrophobic and/or polar neutral properties facilitate or stabilize peptide binding with tyrosinase, and short peptides with cysteine and tyrosine tend to bind to the active site of tyrosinase. These findings provide detailed explanations for the relationship between peptide/amino acid structures and tyrosinase inhibition, as well as potential anti-melanogenesis mechanisms for peptide-based treatments against skin hyperpigmentation.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ye Yang, Hai-Lian Chen, Su Fang Wu, Wei Bao
Summary: The study found that CHMP4B and VPS4A play an important role in reversing GSDMD-mediated pyroptosis by facilitating cell membrane remodeling in endometrial carcinoma.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aya Al Othman, Dmitry Bagrov, Julian M. Rozenberg, Olga Glazova, Gleb Skryabin, Elena Tchevkina, Alexandre Mezentsev, Mikhail Durymanov
Summary: Arc protein is found in glutamatergic neurons of vertebrates and can be transferred between neurons in extracellular vesicles (EVs). In glioma cells, Arc protein is also present in EVs and can facilitate the transfer of mRNA, potentially contributing to tumor progression and affecting synaptic plasticity in cancer patients.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Nan Zhang, Meng-yu Shen, Qing-li Meng, Hao-ping Sun, Fang-yi Fan, Hai Yi, Yong-jian Yang
Summary: In this study, it was demonstrated for the first time that FAT1 inhibited AML proliferation by reducing autophagy level. FAT1 achieved this by decreasing the expression of ATG4B, which is related to autophagy. Mechanistically, FAT1 decreased the levels of phosphorylated and intranuclear smad2/3, thus decreasing the activity of the ATG4B gene promoter. It was also found that FAT1 competitively bound to TGF-beta R II, leading to reduced phosphorylation of TGF-beta R I and smad2/3. Knockdown of FAT1 promoted AML autophagy and proliferation in vivo.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Oleh Demianchuk, Myroslava Vatashchuk, Dmytro Gospodaryov, Viktoria Hurza, Marian Ivanochko, Vitalii Derkachov, Vladyslav Berezovskyi, Oleh Lushchak, Kenneth B. Storey, Maria Bayliak, Volodymyr I. Lushchak
Summary: This study investigated the effects of a high-fat high-fructose diet (HFFD) on the behavior, energy metabolism, and oxidative stress markers in the cerebral cortex of mice. The results showed that HFFD stimulated locomotion and defecation, while an AKG-supplemented diet had a tendency to promote anxiety-like behavior. Additionally, there were significant differences in glutathione-dependent detoxification and processes related to autophagy between the two diets.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Yusaku Chukai, Ginga Ito, Yasuo Miki, Koichi Wakabayashi, Ken Itoh, Eriko Sugano, Hiroshi Tomita, Tomokazu Fukuda, Taku Ozaki
Summary: The study found that mitochondrial calpain-5 plays an important role in the occurrence and development of ischemia-reperfusion injury and is expressed in the human and mouse brains. Targeting the expression or activity of mitochondrial calpain-5 may have significant implications for suppressing inflammation during I/R injuries such as cerebrovascular diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Aline Dias da Purificaca, Victor Debbas, Leonardo Yuji Tanaka, Gabriele Veronica de Mello Gabriel, Joao Wosniak Junior, Tiphany Coralie De Bessa, Sheila Garcia-Rosa, Francisco Rafael Martins Laurindo, Percillia Victoria Santos Oliveira
Summary: The ER transmembrane chaperones DNAJB12 and DNAJB14 play important roles in protein folding and ER stress response. They are regulated by thiol redox processes and are involved in ER protein reflux.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Ekaterina O. Bryanskaya, Andrey Y. Vinokurov, Angelina I. Dolgikh, Andrey Dunaev, Plamena R. Angelova, Andrey Y. Abramov
Summary: FAD autofluorescence in cells can assess enzymatic activity, and its intensity variations may be related to different cell types and tissues. High levels of FAD autofluorescence can indicate cell pathology and potentially predict the occurrence of apoptosis and necrosis.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
Article
Biochemistry & Molecular Biology
Rumei Luan, Manyu Luo, Dongyan Ding, Xin Su, Junling Yang
Summary: Zinc deficiency can worsen obesity-related lung damage, and Nrf2 activation is one of the important mechanisms of this protective effect. Regulating zinc homeostasis can contribute to the prevention and treatment of obesity-related lung injury.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2024)
