Review
Cell Biology
Linbin Zhou, Danny Siu-Chun Ng, Jason C. Yam, Li Jia Chen, Clement C. Tham, Chi Pui Pang, Wai Kit Chu
Summary: This review summarizes recent findings on the impact of post-translational modifications (PTMs) on the functions of retinoblastoma protein (pRb). PTMs on pRb play crucial roles in cell cycle regulation, cell survival, and differentiation, and altered PTMs can lead to anomalies in cell proliferation and tumorigenesis. Understanding the post-translational modulation of pRb could facilitate the development of novel therapeutic strategies for various human diseases.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Cell Biology
Robert S. Rogers, Annemarie Parker, Phill D. Vainer, Elijah Elliott, Dakota Sudbeck, Kaushal Parimi, Venkata P. Peddada, Parker G. Howe, Nick D'Ambrosio, Gregory Ruddy, Kaitlin Stackable, Megan Carney, Lauren Martin, Thomas Osterholt, Jeff L. Staudinger
Summary: Pregnane X receptor (PXR) is highly expressed in the enterohepatic system and regulates the expression of genes encoding key drug metabolizing enzymes and drug transporter proteins. Activation of PXR increases metabolism and clears drugs and xenobiotics from the body, mediating important drug interactions. PXR activation also transrepresses inflammatory- and nutrient-signaling pathways, connecting these pathways with drug biotransformation pathways. Research on post-translational modifications (PTMs) of PXR is still in its early stages.
Review
Biochemistry & Molecular Biology
Siyi Zhang, Tingting Zhou, Zhuo Wang, Fei Yi, Chunlu Li, Wendong Guo, Hongde Xu, Hongyan Cui, Xiang Dong, Jingwei Liu, Xiaoyu Song, Liu Cao
Summary: Faithful DNA replication is crucial for cell survival and inheritance, but damage can lead to replication stalling and DNA lesions. Post-translational modifications of PCNA regulate DNA synthesis and damage tolerance to maintain genomic stability. Dysregulation of PCNA PTMs can result in DNA breaks, affecting cell response and causing mutations.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Cell Biology
Chunhua Yang, Mengna Wei, Yanpu Zhao, Zhanyi Yang, Mengyao Song, Jia Mi, Xiaoyong Yang, Geng Tian
Summary: Post-translational modifications (PTMs) in pancreatic beta cells play crucial roles in insulin secretion and have significant implications for diabetes mellitus development. This article summarizes the major PTMs occurring in beta cells and their impact on insulin secretion, providing valuable insights into the understanding of insulin secretion mechanisms and potential therapeutic targets for diabetes from the perspective of protein PTMs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yanfeng Wang, Feng Wang
Summary: Post-translational modifications like ubiquitination play crucial roles in regulating biological processes in eukaryotes, with DUBs being key enzymes that control ubiquitin-related pathways. Dysregulation of DUBs can lead to various diseases. Phosphorylation is the most extensively studied post-translational modification of DUBs, influencing their function and activity.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ivana Samarzija
Summary: The specific functional form of a protein is mostly achieved through dynamic interactions of many enzymes in post-translational modifications, which cells widely use to respond to stimuli, regulate transcription, and maintain proteostasis. Post-translational modifications play important roles in driving prostate cancer, particularly in regulating protein activity at the level of post-translational modifications.
Review
Biochemistry & Molecular Biology
Celia R. Bloom, Brian J. North
Summary: BubR1 plays a crucial role in mitosis and its post-translational modifications are important for its function, which may be associated with pathological conditions.
CELL AND BIOSCIENCE
(2021)
Review
Clinical Neurology
Carolina Alquezar, Shruti Arya, Aimee W. Kao
Summary: Post-translational modifications play a crucial role in regulating tau protein function, including phosphorylation and acetylation. While these modifications may regulate protein function under normal conditions, they can be hijacked in disease states. Limited understanding exists on how these modifications impact tau protein, but studies indicate their critical role in localization, interactions, and other aspects.
FRONTIERS IN NEUROLOGY
(2021)
Article
Behavioral Sciences
Jaquelini B. Canever, Ericks Sousa Soares, Nubia C. P. de Avelar, Helena I. Cimarosti
Summary: This review provides an overview of the pathophysiological roles of alpha-synuclein in Parkinson's disease and discusses various post-translational modifications that are implicated in its functions. It also highlights the potential of alpha-synuclein PTMs as biomarkers for PD.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Shuaishuai Zhang, Manlan Guo, Xiaowen Jiang, Lan Tang, Ting Wu, Guofang Bi, Xiao Yang, Shicheng Fan, Huichang Bi
Summary: This study reveals the mechanisms by which PXR induces liver enlargement and regeneration through the regulation of YAP acetylation, ubiquitination, and YAP-TEAD binding, providing evidence for using PXR as a potential target to promote hepatic development and liver repair.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Wei-hua Wang, Tao Yuan, Mei-jia Qian, Fang-jie Yan, Liu Yang, Qiao-jun He, Bo Yang, Jin-jian Lu, Hong Zhu
Summary: This review discusses the regulatory mode of post-translational modifications on KRAS, including prenylation, phosphorylation, and more, while highlighting recent studies targeting these modifications that have shown potent anti-tumor activities.
ACTA PHARMACOLOGICA SINICA
(2021)
Review
Oncology
Ana Gonzalez-Garcia, Antonio Garrido, Ana C. Carrera
Summary: Genetic alterations in the PI3-kinase/PTEN pathway are common in cancer cells. Current efforts to treat PTEN-dependent tumors mainly focus on PI3-kinase inhibition, but modulating PTEN post-translational modifications could provide alternative therapeutic strategies.
Article
Biochemistry & Molecular Biology
Nicole E. Pellegrino, Arcan Guven, Kayleigh Gray, Punit Shah, Gargi Kasture, Maria-Dorothea Nastke, Anjan Thakurta, Stephane Gesta, Vivek K. Vishnudas, Niven R. Narain, Michael A. Kiebish
Summary: Post-translational modifications of proteins play a crucial role in regulating cellular processes, and their abnormalities are associated with diseases. This review discusses the role, regulatory mechanisms, and assay capabilities of ubiquitination, SUMOylation, and NEDDylation in tumorigenesis. These modifications are closely related to cancer biology and tumor development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Katie Dunphy, Paul Dowling, Despina Bazou, Peter O'Gorman
Summary: This review discusses techniques used for PTM analysis and their applications in blood cancer research. Mass spectrometry-based techniques are at the forefront of PTM analysis due to their ability to detect large numbers of modified proteins with high sensitivity and specificity. Immuno-based techniques remain popular, with improvements in the quality of commercially available modification-specific antibodies facilitating the detection of modified proteins with high affinity. PTM-focused studies on blood cancers have provided information on altered cellular processes that contribute to the malignant phenotype, while many blood cancer therapies target protein modifications to exert their anti-cancer effects. Continued optimization of protocols and techniques for PTM analysis in blood cancer research will lead to novel insights into mechanisms of malignant transformation and the identification of new biomarkers and therapeutic targets.
Review
Biochemistry & Molecular Biology
Catherine Gough, Ari Sadanandom
Summary: Plants have evolved complex defence signalling networks to combat pathogen attacks, with post-translational modifications playing a crucial role in plant immunity. Manipulating defence-related PTMs has the potential to produce disease-resistant crops without compromising growth and fitness.
Review
Pharmacology & Pharmacy
Jeff L. Staudinger, Sarah Woody, Mengxi Sun, Wenqi Cui
DRUG METABOLISM REVIEWS
(2013)
Article
Multidisciplinary Sciences
Devon S. Svoboda, M. Inmaculada Barrasa, Jian Shu, Rosalie Rietjens, Shupei Zhang, Maya Mitalipova, Peter Berube, Dongdong Fu, Leonard D. Shultz, George W. Bell, Rudolf Jaenisch
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Cell Biology
Wenqi Cui, Aishwarya Sathyanarayan, Michael Lopresti, Mariam Aghajan, Chi Chen, Douglas G. Mashek
Summary: The autophagic degradation of lipid droplets, termed lipophagy, is a major mechanism that contributes to lipid turnover in numerous cell types. This study demonstrates that the fusion of lysosomes to the plasma membrane is the primary route for the disposal of fatty acids derived from lipophagy. Additionally, the efflux of fatty acids and their reuptake or subsequent extracellular trafficking may play a crucial role in cell-to-cell lipid exchange and signaling.
Article
Biochemistry & Molecular Biology
Enxiang Zhang, Wenqi Cui, Michael Lopresti, Mara T. Mashek, Charles P. Najt, Hongbo Hu, Douglas G. Mashek
JOURNAL OF LIPID RESEARCH
(2020)
Article
Cell & Tissue Engineering
Malkiel A. Cohen, Shupei Zhang, Satyaki Sengupta, Haiting Ma, George W. Bell, Brendan Horton, Bandana Sharma, Rani E. George, Stefani Spranger, Rudolf Jaenisch
Article
Pharmacology & Pharmacy
Wenqi Cui, Xunan Shen, Emre Agbas, Brandon Tompkins, Hadley Cameron-Carter, Jeff L. Staudinger
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2020)
Article
Multidisciplinary Sciences
Qiang Huang, Malkiel A. Cohen, Fernando C. Alsina, Garth Devlin, Aliesha Garrett, Jennifer McKey, Patrick Havlik, Nikolai Rakhilin, Ergang Wang, Kun Xiang, Parker Mathews, Lihua Wang, Cheryl Bock, Victor Ruthig, Yi Wang, Marcos Negrete, Chi Wut Wong, Preetish K. L. Murthy, Shupei Zhang, Andrea R. Daniel, David G. Kirsch, Yubin Kang, Blanche Capel, Aravind Asokan, Debra L. Silver, Rudolf Jaenisch, Xiling Shen
Article
Multidisciplinary Sciences
Elisa M. Floriddia, Tania Lourenco, Shupei Zhang, David van Bruggen, Markus M. Hilscher, Petra Kukanja, Joao P. Goncalves dos Santos, Muge Altinkok, Chika Yokota, Enric Llorens-Bobadilla, Sara B. Mulinyawe, Mario Graos, Lu O. Sun, Jonas Frisen, Mats Nilsson, Goncalo Castelo-Branco
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Michael W. Lopresti, Wenqi Cui, Breann Abernathy, Gavin Fredrickson, Fanta Barrow, Arnav S. Desai, Xavier S. Revelo, Douglas Mashek
Summary: The hepatic overexpression of LAL does not alleviate the progression of NAFLD, but instead exacerbates inflammation and immune cell infiltration in mice fed a Western diet.
JOURNAL OF LIPID RESEARCH
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Michael Lopresti, Wenqi Cui, Breann Abernathy, Gavin Fredrickson, Xavier Revelo, Douglas Mashek
Meeting Abstract
Biochemistry & Molecular Biology
Wenqi Cui, Mengxi Sun, Xunan Shen, Jeff Staudinger
Article
Pharmacology & Pharmacy
Wenqi Cui, Mengxi Sun, Nadezhda Galeva, Todd D. Williams, Yoshiaki Azuma, Jeff L. Staudinger
DRUG METABOLISM AND DISPOSITION
(2015)
Article
Pharmacology & Pharmacy
Mengxi Sun, Wenqi Cui, Sarah K. Woody, Jeff L. Staudinger
DRUG METABOLISM AND DISPOSITION
(2015)
Article
Biochemistry & Molecular Biology
Damien Marchese, Florent Guislain, Tamara Pringels, Laure Bridoux
Summary: Homopolymeric amino acid repeats are common in human proteins, particularly in transcription factors and kinases. This study focuses on homopolymeric histidine repeats (polyH) and their role in regulating embryonic development. Through bioinformatic analysis, the study identifies that polyH-containing proteins interact with cysteine-rich proteins and proteins containing cysteine repeats. The study further investigates the HOXA1 protein, a transcription factor with a long polyH motif, and finds that the polyH motif is necessary for its interaction with cysteine-rich proteins. Additionally, the study discovers that metal ions are required for the HOXA1-MDFI interaction and identifies three polyH interactors that down-regulate the transcriptional activity of HOXA1.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2024)