EGFR/ErbB Inhibition Promotes OPC Maturation up to Axon Engagement by Co-Regulating PIP2 and MBP

Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation

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Molecular Control of Oligodendrocyte Development

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Forskolin improves sensitivity to doxorubicin of triple negative breast cancer cells via Protein Kinase A-mediated ERK1/2 inhibition

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Engineered 3D-printed artificial axons

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Synthesis and PI3 Kinase Inhibition Activity of a Wortmannin-Leucine Derivative

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Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

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Targeting Smoothened as a New Frontier in the Functional Recovery of Central Nervous System Demyelinating Pathologies

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Metabolomics-based discovery of a metabolite that enhances oligodendrocyte maturation

(2017) Brittney A Beyer et al.   Nature Chemical Biology

Remyelination therapies: a new direction and challenge in multiple sclerosis

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Targeting sonic hedgehog signaling in neurological disorders

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Oligodendrocyte progenitor programming and reprogramming: Toward myelin regeneration

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Cdon, a cell surface protein, mediates oligodendrocyte differentiation and myelination

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Oligodendrocyte regeneration: Its significance in myelin replacement and neuroprotection in multiple sclerosis

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Clobetasol promotes remyelination in a mouse model of neuromyelitis optica

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Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

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Identification of gefitinib off-targets using a structure-based systems biology approach; their validation with reverse docking and retrospective data mining

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Insulin activates EGFR by stimulating its interaction with IGF-1R in low-EGFR-expressing TNBC cells

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SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer

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CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes

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Myelination: Actin Disassembly Leads the Way

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CNS Myelin Wrapping Is Driven by Actin Disassembly

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Actin Filament Turnover Drives Leading Edge Growth during Myelin Sheath Formation in the Central Nervous System

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Selective ligand activity at Nur/retinoid X receptor complexes revealed by dimer-specific bioluminescence resonance energy transfer-based sensors

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Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination

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Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo

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Transcriptional and Epigenetic Regulation of Oligodendrocyte Development and Myelination in the Central Nervous System

(2015) Ben Emery et al.   Cold Spring Harbor Perspectives in Biology

Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation

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Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors

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Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Motor skill learning requires active central myelination

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Axon-glia interaction and membrane traffic in myelin formation

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The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases

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Genetic Activation of Hedgehog Signaling Unbalances the Rate of Neural Stem Cell Renewal by Increasing Symmetric Divisions

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Smoothened Oligomerization/Higher Order Clustering in Lipid Rafts Is Essential for High Hedgehog Activity Transduction

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Sonic Hedgehog Signaling Is a Positive Oligodendrocyte Regulator during Demyelination

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Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines

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A regenerative approach to the treatment of multiple sclerosis

(2013) Vishal A. Deshmukh et al.   NATURE

The quest for myelin in the adult brain

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Mapping the human phosphatome on growth pathways

(2012) Francesca Sacco et al.   Molecular Systems Biology

Oligodendroglia metabolically support axons and contribute to neurodegeneration

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Deconstructing myelination: it all comes down to size

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Oligodendrogenesis in the subventricular zone and the role of epidermal growth factor

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Neuregulin signaling, cortical circuitry development and schizophrenia

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Retinoid X receptor gamma signaling accelerates CNS remyelination

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Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation

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Identification of select glucocorticoids as Smoothened agonists: Potential utility for regenerative medicine

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Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination

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Phosphatidylinositol 4,5-Bisphosphate-Dependent Interaction of Myelin Basic Protein with the Plasma Membrane in Oligodendroglial Cells and Its Rapid Perturbation by Elevated Calcium

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ErbB receptors and the development of the nervous system

(2008) Carmen Birchmeier   EXPERIMENTAL CELL RESEARCH

Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2–dependent RNA granules

(2008) Robin White et al.   JOURNAL OF CELL BIOLOGY

Potentiation by Thrombin of Hyposmotic Glutamate and Taurine Efflux from Cultured Astrocytes: Signalling Chains

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Functional selectivity of EGF family peptide growth factors: Implications for cancer

(2008) Kristy J. Wilson et al.   PHARMACOLOGY & THERAPEUTICS