Review
Clinical Neurology
Vanja Tepavcevi, Catherine Lubetzki
Summary: The failure of remyelination in multiple sclerosis (MS) is often characterized by low oligodendrocyte progenitor cell density. Stimulating this process may be crucial for achieving myelin regeneration.
Article
Biochemistry & Molecular Biology
Ulises Gomez-Pinedo, Jordi A. Matias-Guiu, Maria Soledad Benito-Martin, Lidia Moreno-Jimenez, Inmaculada Sanclemente-Alaman, Belen Selma-Calvo, Sara Perez-Suarez, Francisco Sancho-Bielsa, Alejandro Canales-Aguirre, Juan Carlos Mateos-Diaz, Mercedes A. Hernandez-Sapiens, Edwin E. Reza-Zaldivar, Doddy Denise Ojeda-Hernandez, Lucia Vidorreta-Ballesteros, Paloma Montero-Escribano, Jorge Matias-Guiu
Summary: The study demonstrated that delivering HOG cells through the nasal route resulted in preferential migration to niches of OPCs in the CNS, potentially contributing to remyelination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ilias Kalafatakis, Domna Karagogeos
Summary: This review summarizes the regulation of myelination by oligodendrocytes under physiological and pathological conditions, as well as the role of microglia in myelin generation, regeneration, and repair. The beneficial and detrimental roles of microglia in remyelination are discussed, along with the cellular and molecular components involved. Recent findings related to preclinical models using human stem cells for studying microglia in human pathologies and the impact of the microbiome on glial cell functions are also presented.
Article
Multidisciplinary Sciences
Tess Dierckx, Sam Vanherle, Mansour Haidar, Elien Grajchen, Fleur Mingneau, Pascal Gervois, Esther Wolfs, Dany Bylemans, Arnout Voet, Tien Nguyen, Ibrahim Hamad, Markus Kleinewietfeld, Jeroen F. J. Bogie, Jerome J. A. Hendriks
Summary: This study reveals the reasons for the failure of remyelination, including the overly inflammatory microenvironment and the intrinsic inability of oligodendrocyte precursor cells to differentiate. The study also shows that phloretin can significantly promote remyelination by acting on the nuclear receptor peroxisome proliferator-activated receptor gamma to promote the maturation of oligodendrocyte precursor cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Haritha L. Desu, Placido Illiano, James S. Choi, Maureen C. Ascona, Han Gao, Jae K. Lee, Roberta Brambilla
Summary: The study reveals that neuroinflammation in multiple sclerosis leads to a shift in oligodendrocyte precursor cells (OPCs) towards an immunomodulatory phenotype, reducing their remyelination capacity and impairing their repair function. Furthermore, enhancing TNFR2 activation could be an effective strategy to restore OPC reparative capacity.
Review
Neurosciences
Morgan W. Psenicka, Brandon C. Smith, Rachel A. Tinkey, Jessica L. Williams
Summary: Neurodegenerative diseases often involve inflammation, and multiple sclerosis (MS) is a complex interplay between inflammation and neurodegeneration. Oligodendrocyte precursor cells (OPCs) play an active role in promoting neuroinflammation and neurodegeneration in MS, in addition to being a target of autoimmune pathology.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Yuan-Yuan Xie, Ting-Ting Pan, De-en Xu, Xin Huang, Yong Tang, Wenhui Huang, Rui Chen, Li Lu, Hao Chi, Quan-Hong Ma
Summary: Clemastine, an H1-antihistamine, has the potential to induce OPC differentiation and myelin formation under different neuropathological conditions. In aged APPSwe/PS1dE9 mice, chronic clemastine treatment reduced brain amyloid-beta deposition, improved short-term memory deficit, enhanced OPC density, and prevented OPCs from entering cellular senescence, showing therapeutic potential in Alzheimer's disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Neurosciences
Karina Maciak, Angela Dziedzic, Joanna Saluk
Summary: Remyelination depends on the repair of damaged myelin sheaths, involving microglia cells, oligodendrocyte precursor cells (OPCs), and mature oligodendrocytes. Short, noncoding RNA molecules, microRNAs (miRNAs), are believed to play a crucial role in the remyelination process by regulating gene expression. Various delivery systems, including extracellular vesicles, hold promise as an efficient and non-invasive way for providing miRNAs to stimulate remyelination.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
James J. M. Cooper, Jessie J. Polanco, Darpan Saraswat, Jennifer J. Peirick, Anna Seidl, Yi Li, Dan Ma, Fraser J. Sim
Summary: The failure of remyelination in the human CNS is a major contributor to axonal injury and disease progression in multiple sclerosis (MS). Murine models show a high density of oligodendrocyte progenitor cells (OPCs) in areas of demyelination, suggesting that efficient OPC repopulation is necessary for successful remyelination. However, in this study, we found that OPC repopulation was low in large lesions and almost absent in small lesions in adult rabbits, suggesting that both lesion volume and species-specific mechanisms play a role in regulating OPC proliferation and remyelination.
Article
Multidisciplinary Sciences
Jayshree Samanta, Hernandez Moura Silva, Juan J. Lafaille, James L. Salzer
Summary: Gli1-expressing neural stem cells in the subventricular zone of the adult mammalian brain have the ability to generate new oligodendrocytes for remyelination. Loss or inhibition of Gli1 enhances remyelination efficacy and may be a potential therapeutic strategy for demyelinating diseases like multiple sclerosis. Transcriptomic analysis of these neural stem cells provides valuable insights for identifying therapeutic targets to enhance remyelination.
Article
Biochemistry & Molecular Biology
Yizi Zhu, Mingzhu Chen, Yubo Zhang, Mei Han
Summary: This study found that stemazole can enhance the survival rate and clone formation of oligodendrocyte precursor cells (OPCs) and decrease cell apoptosis. In addition, in vivo experiments showed that stemazole promotes the recovery of motor dysfunction and repair of myelin sheaths. These findings suggest that stemazole may be a potential therapeutic agent for demyelinating diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Ulises Gomez-Pinedo, Jordi A. Matias-Guiu, Denise Ojeda-Hernandez, Sarah de la Fuente-Martin, Ola Mohamed-Fathy Kamal, Maria Soledad Benito-Martin, Belen Selma-Calvo, Paloma Montero-Escribano, Jorge Matias-Guiu
Summary: The implantation of oligodendrocyte precursor cells is a potential therapeutic strategy for remyelination. However, it is unclear how these cells behave after implantation and if they retain the ability to proliferate and differentiate into myelin-forming oligodendrocytes. This study evaluates the impact of corticosteroids on cell proliferation, differentiation, and survival, finding that corticosteroids reduce these capacities and do not support remyelination.
Article
Neurosciences
Haley E. Titus, Huan Xu, Andrew P. Robinson, Priyam A. Patel, Yanan Chen, Damiano Fantini, Valerie Eaton, Molly Karl, Eric D. Garrison, Indigo V. L. Rose, Ming Yi Chiang, Joseph R. Podojil, Roumen Balabanov, Shane A. Liddelow, Robert H. Miller, Brian Popko, Stephen D. Miller
Summary: Multiple sclerosis is an autoimmune disease of the central nervous system characterized by inflammation, demyelination, and neurodegeneration. This study found that digoxin, a medication used for cardiac conditions, promoted myelin repair and axonal integrity. This research provides important evidence for future clinical trials in multiple sclerosis patients.
Article
Neurosciences
Omri Zveik, Nina Fainstein, Ariel Rechtman, Nitzan Haham, Tal Ganz, Iris Lavon, Livnat Brill, Adi Vaknin-Dembinsky
Summary: Oligodendrocyte progenitor cells play a role in both remyelination and immune response in the central nervous system. CSF from patients with progressive MS impairs differentiation of OPCs and reduces immune functions.
Review
Neurosciences
Kelley C. C. Atkinson, Marvellous Osunde, Seema K. K. Tiwari-Woodruff
Summary: Multiple sclerosis (MS) is a degenerative disorder of the central nervous system (CNS) with mitochondrial energy production failure. Mitochondrial morphology changes and impaired transport contribute to neurodegeneration and disability in MS. Current methodologies for studying mitochondria in MS only provide a partial understanding, and cell-specific studies in animal models are needed for a comprehensive understanding.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Cell Biology
Alerie Guzman de la Fuente, Oihana Errea, Peter van Wijngaarden, Ginez A. Gonzalez, Christophe Kerninon, Andrew A. Jarjour, Hilary J. Lewis, Clare A. Jones, Brahim Nait-Oumesmar, Chao Zhao, Jeffrey K. Huang, Charles Ffrench-Constant, Robin J. M. Franklin
JOURNAL OF CELL BIOLOGY
(2015)
Article
Neurosciences
Sarah Moyon, Anne Laure Dubessy, Marie Stephane Aigrot, Matthew Trotter, Jeffrey K. Huang, Luce Dauphinot, Marie Claude Potier, Christophe Kerninon, Stephane Melik Parsadaniantz, Robin J. M. Franklin, Catherine Lubetzki
JOURNAL OF NEUROSCIENCE
(2015)
Article
Chemistry, Multidisciplinary
Tian Xie, Ankit Vora, Patrick J. Mulcahey, Sonia E. Nanescu, Manpreet Singh, Daniel S. Choi, Jeffrey K. Huang, Chi-Chun Liu, Daniel P. Sanders, Jong-in Hahm
Article
Clinical Neurology
Konstantina Psachoulia, Kelly A. Chamberlain, Dongeun Heo, Stephanie E. Davis, Jeremiah D. Paskus, Sonia E. Nanescu, Jeffrey L. Dupree, Thomas A. Wynn, Jeffrey K. Huang
Editorial Material
Neurosciences
Jeffrey K. Huang, Ragnhildur T. Karadottir
Editorial Material
Cell & Tissue Engineering
Tara Walker, Jeffrey Huang, Kaylene Young
STEM CELLS INTERNATIONAL
(2016)
Article
Neurosciences
Kelly A. Chamberlain, Kristen S. Chapey, Sonia E. Nanescu, Jeffrey K. Huang
JOURNAL OF NEUROSCIENCE
(2017)
Review
Clinical Neurology
Lauren Rosko, Victoria N. Smith, Reiji Yamazaki, Jeffrey K. Huang
Article
Multidisciplinary Sciences
Maryna Baydyuk, David S. Cha, Jingwen Hu, Reiji Yamazaki, Evan M. Miller, Victoria N. Smith, Katherine A. Kelly, Jeffrey K. Huang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biochemistry & Molecular Biology
Maryna Baydyuk, Vivianne E. Morrison, Phillip S. Gross, Jeffrey K. Huang
NEUROCHEMICAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Reiji Yamazaki, Nobuhiko Ohno, Jeffrey K. Huang
Summary: The study found that focal IC demyelination induced by LPC injection resulted in acute motor deficit, but the mice regained motor function and axonal integrity in lesions by 28 days post-lesion through remyelination.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Jingwen Hu, Maryna Baydyuk, Jeffrey K. Huang
Summary: Amino acids play a crucial role in demyelination and remyelination processes by modulating immune activity in the CNS and influencing oligodendrocyte function. Studying amino acid metabolism can enhance our understanding of CNS inflammation and diseases like multiple sclerosis.
CURRENT OPINION IN PHARMACOLOGY
(2022)
Article
Neurosciences
Vivianne E. Morrison, Victoria N. Smith, Jeffrey K. Huang
Review
Chemistry, Medicinal
George S. Melchor, Tahiyana Khan, Joan F. Reger, Jeffrey K. Huang
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2019)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.