Keeping the Centromere under Control: A Promising Role for DNA Methylation

Structural basis of specific DNA binding by the transcription factor ZBTB24

(2019) Ren Ren et al.   NUCLEIC ACIDS RESEARCH

Transposable elements: genome innovation, chromosome diversity, and centromere conflict

(2018) Savannah J. Klein et al.   CHROMOSOME RESEARCH

Chromosome Segregation Is Biased by Kinetochore Size

(2018) Danica Drpic et al.   CURRENT BIOLOGY

Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state

(2018) Guillaume Velasco et al.   HUMAN MOLECULAR GENETICS

Overexpression of satellite alpha transcripts leads to chromosomal instability via segregation errors at specific chromosomes

(2018) Kosuke Ichida et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome

(2018) Christopher Jenness et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome

(2018) Motoko Unoki et al.   JOURNAL OF CLINICAL INVESTIGATION

The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

(2018) V. Barra et al.   Nature Communications

Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome

(2018) Srivarsha Rajshekar et al.   eLife

Rapid molecular assays to study human centromere genomics

(2017) Rafael Contreras-Galindo et al.   GENOME RESEARCH

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

(2017) Lilian Kabeche et al.   SCIENCE

Centromere evolution and CpG methylation during vertebrate speciation

(2017) Kazuki Ichikawa et al.   Nature Communications

Structure of centromere chromatin: from nucleosome to chromosomal architecture

(2016) Thomas Schalch et al.   CHROMOSOMA

Genomic variation within alpha satellite DNA influences centromere location on human chromosomes with metastable epialleles

(2016) Megan E. Aldrup-MacDonald et al.   GENOME RESEARCH

Converging disease genes in ICF syndrome:ZBTB24controls expression ofCDCA7in mammals

(2016) Haoyu Wu et al.   HUMAN MOLECULAR GENETICS

Epigenome Maintenance in Response to DNA Damage

(2016) Juliette Dabin et al.   MOLECULAR CELL

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

(2016) Peter Ly et al.   NATURE CELL BIOLOGY

Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression

(2016) Antoine Aze et al.   NATURE CELL BIOLOGY

The DNA methyltransferase DNMT3C protects male germ cells from transposon activity

(2016) Joan Barau et al.   SCIENCE

Repression of harmful meiotic recombination in centromeric regions

(2016) Mridula Nambiar et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function

(2015) Daniele Fachinetti et al.   DEVELOPMENTAL CELL

DNA methylation epigenetically silences crossover hot spots and controls chromosomal domains of meiotic recombination inArabidopsis

(2015) Nataliya E. Yelina et al.   GENES & DEVELOPMENT

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

The molecular basis for centromere identity and function

(2015) Kara L. McKinley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mutations in CDCA7 and HELLS cause immunodeficiency–centromeric instability–facial anomalies syndrome

(2015) Peter E. Thijssen et al.   Nature Communications

Influence of DNA methylation on positioning and DNA flexibility of nucleosomes with pericentric satellite DNA

(2015) Akihisa Osakabe et al.   Open Biology

The Centromere: Chromatin Foundation for the Kinetochore Machinery

(2014) Tatsuo Fukagawa et al.   DEVELOPMENTAL CELL

Redundant Mechanisms to Form Silent Chromatin at Pericentromeric Regions Rely on BEND3 and DNA Methylation

(2014) Nehmé Saksouk et al.   MOLECULAR CELL

DNA Methylation in Mammals

(2014) E. Li et al.   Cold Spring Harbor Perspectives in Biology

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

Heterogeneous clinical presentation in ICF syndrome: correlation with underlying gene defects

(2013) Corry MR Weemaes et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A two-step mechanism for epigenetic specification of centromere identity and function

(2013) Daniele Fachinetti et al.   NATURE CELL BIOLOGY

Effects of DNA methylation on nucleosome stability

(2013) Clayton K. Collings et al.   NUCLEIC ACIDS RESEARCH

Neocentromeres: a place for everything and everything in its place

(2013) Kristin C. Scott et al.   TRENDS IN GENETICS

Programming of DNA Methylation Patterns

(2012) Howard Cedar et al.   Annual Review of Biochemistry

Maintenance of DNA methylation: Dnmt3b joins the dance

(2012) Emma L. Walton et al.   Epigenetics

The SNF2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells

(2012) Joe Burrage et al.   JOURNAL OF CELL SCIENCE

Roles of Mis18α in Epigenetic Regulation of Centromeric Chromatin and CENP-A Loading

(2012) Ik Soo Kim et al.   MOLECULAR CELL

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Deficiency in DNA methylation increases meiotic crossover rates in euchromatic but not in heterochromatic regions in Arabidopsis

(2012) C. Melamed-Bessudo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of DNA methylation affects the recombination landscape in Arabidopsis

(2012) M. Mirouze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases

(2012) Julia Arand et al.   PLoS Genetics

Mutations in ZBTB24 Are Associated with Immunodeficiency, Centromeric Instability, and Facial Anomalies Syndrome Type 2

(2011) Jessica C. de Greef et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genomic size of CENP-A domain is proportional to total alpha satellite array size at human centromeres and expands in cancer cells

(2011) Lori L. Sullivan et al.   CHROMOSOME RESEARCH

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

(2011) Sanjeev Shukla et al.   NATURE

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore

(2010) Jan H Bergmann et al.   EMBO JOURNAL

The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats

(2010) Claudio Guetg et al.   EMBO JOURNAL

Cell cycle-dependent accumulation of histone H3.3 and euchromatic histone modifications in pericentromeric heterochromatin in response to a decrease in DNA methylation levels

(2010) Kazuto Sugimura et al.   EXPERIMENTAL CELL RESEARCH

Condensin complexes regulate mitotic progression and interphase chromatin structure in embryonic stem cells

(2010) Thomas G. Fazzio et al.   JOURNAL OF CELL BIOLOGY

DNA Methylation Increases Nucleosome Compaction and Rigidity

(2010) John S. Choy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail

(2010) Yingying Zhang et al.   NUCLEIC ACIDS RESEARCH

Altered Intra-Nuclear Organisation of Heterochromatin and Genes in ICF Syndrome

(2010) Andrew Jefferson et al.   PLoS One

Genome-Wide Evolutionary Analysis of Eukaryotic DNA Methylation

(2010) A. Zemach et al.   SCIENCE

Centromeres Convert but Don't Cross

(2010) Paul B. Talbert et al.   PLOS BIOLOGY

The life and miracles of kinetochores

(2009) Stefano Santaguida et al.   EMBO JOURNAL

Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX–DNMT3–DNMT3L domain

(2009) Junji Otani et al.   EMBO REPORTS

DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions

(2009) Suhasni Gopalakrishnan et al.   HUMAN MOLECULAR GENETICS

G2 histone methylation is required for the proper segregation of chromosomes

(2009) R. Heit et al.   JOURNAL OF CELL SCIENCE

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

Centromere mitotic recombination in mammalian cells

(2008) Isabel Jaco et al.   JOURNAL OF CELL BIOLOGY

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

(2008) Fabio Mohn et al.   MOLECULAR CELL