PTEN Alterations as a Potential Mechanism for Tumor Cell Escape from PD-1/PD-L1 Inhibition
出版年份 2019 全文链接
标题
PTEN Alterations as a Potential Mechanism for Tumor Cell Escape from PD-1/PD-L1 Inhibition
作者
关键词
-
出版物
Cancers
Volume 11, Issue 9, Pages 1318
出版商
MDPI AG
发表日期
2019-09-09
DOI
10.3390/cancers11091318
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mechanisms of PTEN loss in cancer: It’s all about diversity
- (2019) Virginia Álvarez-Garcia et al. SEMINARS IN CANCER BIOLOGY
- Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma
- (2019) Junfei Zhao et al. NATURE MEDICINE
- A retrospective cohort study of PD-L1 prevalence, molecular associations and clinical outcomes in patients with NSCLC: Results from the European Thoracic Oncology Platform (ETOP) Lungscape Project
- (2019) Keith M Kerr et al. LUNG CANCER
- Transforming Growth Factor-β Signaling in Immunity and Cancer
- (2019) Eduard Batlle et al. IMMUNITY
- PI 3K δ is a Treg target in cancer immunotherapy
- (2019) Ee Lyn Lim et al. IMMUNOLOGY
- Tumor-Associated Neutrophils in Cancer: Going Pro
- (2019) Wu et al. Cancers
- PTEN Hamartoma Tumor Syndrome: A Clinical Overview
- (2019) Robert Pilarski Cancers
- The PTEN–PI3K Axis in Cancer
- (2019) Papa et al. Biomolecules
- Mechanisms of resistance to immune checkpoint inhibitors
- (2018) Russell W Jenkins et al. BRITISH JOURNAL OF CANCER
- MiR-19a negatively regulated the expression of PTEN and promoted the growth of ovarian cancer cells
- (2018) Yuhong Wang et al. GENE
- Regulation and Function of the PD-L1 Checkpoint
- (2018) Chong Sun et al. IMMUNITY
- Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic β-Catenin, PIK3CA and MET
- (2018) Jacey J. Liu et al. JOURNAL OF HEPATOLOGY
- The functions and regulation of the PTEN tumour suppressor: new modes and prospects
- (2018) Yu-Ru Lee et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth
- (2018) Helen B. Pearson et al. Cancer Discovery
- Expression of phosphatase and tensin homolog and programmed cell death ligand 1 in adenosquamous carcinoma of the lung
- (2018) Aung Myo Hlaing et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Genomics of response to immune checkpoint therapies for cancer: implications for precision medicine
- (2018) Jake R. Conway et al. Genome Medicine
- Loss of PTEN Is Associated with Resistance to Anti-PD-1 Checkpoint Blockade Therapy in Metastatic Uterine Leiomyosarcoma
- (2017) Suzanne George et al. IMMUNITY
- Tumor-associated macrophages: from basic research to clinical application
- (2017) Li Yang et al. Journal of Hematology & Oncology
- Protein Expression of Programmed Death 1 Ligand 1 and HER2 in Gastric Carcinoma
- (2017) Eiji Oki et al. ONCOLOGY
- IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks
- (2017) Bryan Serrels et al. Science Signaling
- Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance
- (2017) Whijae Roh et al. Science Translational Medicine
- Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN
- (2017) Andrea Cavazzoni et al. Oncotarget
- Recurrent glioma clinical trial, CheckMate-143: the game is not over yet
- (2017) Anna C. Filley et al. Oncotarget
- IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks
- (2017) Bryan Serrels et al. Science Signaling
- Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment
- (2017) David Gyori et al. Cancers
- New Treatment Opportunities in Phosphatase and Tensin Homolog (PTEN)-Deficient Tumors: Focus on PTEN/Focal Adhesion Kinase Pathway
- (2017) Roberta Alfieri et al. Frontiers in Oncology
- PI3K Inhibition Reduces Mammary Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 Responses
- (2016) Jiqing Sai et al. CLINICAL CANCER RESEARCH
- Analysis of expression of PTEN/PI3K pathway and programmed cell death ligand 1 (PD-L1) in malignant pleural mesothelioma (MPM)
- (2016) S. Cedrés et al. LUNG CANCER
- Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells
- (2016) Olivier De Henau et al. NATURE
- Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations
- (2016) Daniel Sanghoon Shin et al. Cancer Discovery
- Control of PD-L1 Expression by Oncogenic Activation of the AKT–mTOR Pathway in Non–Small Cell Lung Cancer
- (2015) Kristin J. Lastwika et al. CANCER RESEARCH
- Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity
- (2015) Alan Serrels et al. CELL
- Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
- (2015) Lin Zhang et al. NATURE
- PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex
- (2015) P. Liu et al. Cancer Discovery
- Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy
- (2015) W. Peng et al. Cancer Discovery
- cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels
- (2015) Lukas Stanczuk et al. Cell Reports
- PTEN: Multiple Functions in Human Malignant Tumors
- (2015) Michele Milella et al. Frontiers in Oncology
- Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer
- (2014) Claudia Fumarola et al. BIOCHEMICAL PHARMACOLOGY
- Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression
- (2014) Chunxiao Xu et al. CANCER CELL
- PTEN inhibits the invasion and metastasis of gastric cancer via downregulation of FAK expression
- (2014) Ling-Li Zhang et al. CELLULAR SIGNALLING
- Complete Loss of PTEN Protein Expression Correlates with Shorter Time to Brain Metastasis and Survival in Stage IIIB/C Melanoma Patients with BRAFV600 Mutations
- (2014) A. D. Bucheit et al. CLINICAL CANCER RESEARCH
- The tumor suppressor PTEN interacts with p53 in hereditary cancer
- (2014) ATSUKO NAKANISHI et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- MicroRNAs in B-cell lymphomas: how a complex biology gets more complex
- (2014) K Musilova et al. LEUKEMIA
- Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes
- (2014) Steffen Durinck et al. NATURE GENETICS
- A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma
- (2014) Mark R. Gilbert et al. NEW ENGLAND JOURNAL OF MEDICINE
- Assessing PIK3CA and PTEN in Early-Phase Trials with PI3K/AKT/mTOR Inhibitors
- (2014) Filip Janku et al. Cell Reports
- Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity
- (2014) Alberto Toso et al. Cell Reports
- Functions and Regulation of the PTEN Gene in Colorectal Cancer
- (2014) Francesca Molinari et al. Frontiers in Oncology
- The multiple layers of non-genetic regulation of PTEN tumour suppressor activity
- (2013) Nádia C. Correia et al. EUROPEAN JOURNAL OF CANCER
- Advancing Precision Medicine for Prostate Cancer Through Genomics
- (2013) Sameek Roychowdhury et al. JOURNAL OF CLINICAL ONCOLOGY
- Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis
- (2013) Adriana Soler et al. JOURNAL OF EXPERIMENTAL MEDICINE
- PTEN Loss Increases PD-L1 Protein Expression and Affects the Correlation between PD-L1 Expression and Clinical Parameters in Colorectal Cancer
- (2013) Minmin Song et al. PLoS One
- Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?
- (2013) L. M. Coussens et al. SCIENCE
- An immunohistochemical signature comprising PTEN, MYC, and Ki67 predicts progression in prostate cancer patients receiving adjuvant docetaxel after prostatectomy
- (2012) Emmanuel S. Antonarakis et al. CANCER
- The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms
- (2012) Ludovica Ciuffreda et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- The landscape of cancer genes and mutational processes in breast cancer
- (2012) Philip J. Stephens et al. NATURE
- The mutational landscape of lethal castration-resistant prostate cancer
- (2012) Catherine S. Grasso et al. NATURE
- The functions and regulation of the PTEN tumour suppressor
- (2012) Min Sup Song et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis
- (2011) Emilie A. Bard-Chapeau et al. CANCER CELL
- Immunotherapy with PI3K Inhibitor and Toll-Like Receptor Agonist Induces IFN- +IL-17+ Polyfunctional T Cells That Mediate Rejection of Murine Tumors
- (2011) N. A. Marshall et al. CANCER RESEARCH
- Genetic alterations of PTEN in human melanoma
- (2011) Almass-Houd Aguissa-Touré et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Cellular senescence and tumor suppressor gene p16
- (2011) Hani Rayess et al. INTERNATIONAL JOURNAL OF CANCER
- PI3K Pathway Mutations and PTEN Levels in Primary and Metastatic Breast Cancer
- (2011) A. M. Gonzalez-Angulo et al. MOLECULAR CANCER THERAPEUTICS
- Oncogenic Role of the E3 Ubiquitin Ligase NEDD4-1, a PTEN Negative Regulator, in Non-Small-Cell Lung Carcinomas
- (2010) Nicola Amodio et al. AMERICAN JOURNAL OF PATHOLOGY
- PTEN Signaling pathways in glioblastoma
- (2010) Dimpy Koul CANCER BIOLOGY & THERAPY
- Integrative Genomic Profiling of Human Prostate Cancer
- (2010) Barry S. Taylor et al. CANCER CELL
- Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer
- (2010) R. K. Shrimali et al. CANCER RESEARCH
- MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)
- (2010) Ji-guang Zhang et al. CLINICA CHIMICA ACTA
- A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
- (2010) Andrea Alimonti et al. JOURNAL OF CLINICAL INVESTIGATION
- mTOR: from growth signal integration to cancer, diabetes and ageing
- (2010) Roberto Zoncu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Combined PTEN and p27kip1 Protein Expression Patterns Are Associated with Obesity and Prognosis in Endometrial Carcinomas
- (2009) A. Dellas et al. CLINICAL CANCER RESEARCH
- Pten in stromal fibroblasts suppresses mammary epithelial tumours
- (2009) Anthony J. Trimboli et al. NATURE
- BrafV600E cooperates with Pten loss to induce metastatic melanoma
- (2009) David Dankort et al. NATURE GENETICS
- Tenets of PTEN Tumor Suppression
- (2008) Leonardo Salmena et al. CELL
- Repression of PTEN Phosphatase by Snail1 Transcriptional Factor during Gamma Radiation-Induced Apoptosis
- (2008) M. Escriva et al. MOLECULAR AND CELLULAR BIOLOGY
- Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis
- (2008) Shidong Jia et al. NATURE
- Genetic and phenotypic heterogeneity in the PTEN hamartoma tumour syndrome
- (2008) M S Orloff et al. ONCOGENE
- PTEN signaling in brain: neuropathology and tumorigenesis
- (2008) R Endersby et al. ONCOGENE
- PTEN-deficient cancers depend on PIK3CB
- (2008) S. Wee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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