Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations

Treating Disease at the RNA Level with Oligonucleotides

(2019) Arthur A. Levin   NEW ENGLAND JOURNAL OF MEDICINE

Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease

(2019) Robert Shenkar et al.   STROKE

A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis

(2019) Eric M. Chapman et al.   Nature Communications

Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional GrowthNovelty and Significance

(2018) Romuald Girard et al.   CIRCULATION RESEARCH

The Cullin-3–Rbx1–KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB

(2018) Igor Kovačević et al.   JOURNAL OF CELL BIOLOGY

Conditional deletion of Neurog1 in the cerebellum of postnatal mice delays inhibitory interneuron maturation

(2018) Edwin A. Obana et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Phenotypic characterization of murine models of cerebral cavernous malformations

(2018) Hussein A. Zeineddine et al.   LABORATORY INVESTIGATION

Enhanced Expression of TGFBI Promotes the Proliferation and Migration of Glioma Cells

(2018) Shi-Kun  Guo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice

(2018) Miguel Alejandro Lopez-Ramirez et al.   BLOOD

Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells

(2018) Matthew R. Detter et al.   CIRCULATION RESEARCH

Matrix metalloproteinase-12 as an endogenous resolution promoting factor following myocardial infarction

(2018) Alan J. Mouton et al.   PHARMACOLOGICAL RESEARCH

Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations

(2017) Miguel Alejandro Lopez-Ramirez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-Wide Sequencing Reveals MicroRNAs Downregulated in Cerebral Cavernous Malformations

(2017) Souvik Kar et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

(2017) Alan T. Tang et al.   NATURE

Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scientific Advisory Board Clinical Experts Panel

(2017) Amy Akers et al.   NEUROSURGERY

Knockdown of Latent Transforming Growth Factor-β (TGF-β)-Binding Protein 2 (LTBP2) Inhibits Invasion and Tumorigenesis in Thyroid Carcinoma Cells

(2017) Fuqiang Wan et al.   ONCOLOGY RESEARCH

SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function

(2017) Kate E Coleman et al.   eLife

The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells

(2017) Tomohisa Sakaue et al.   Scientific Reports

Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin

(2016) Saverio Francesco Retta et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models

(2016) Changbin Shi et al.   Journal of Neuroimmune Pharmacology

Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling

(2016) Zinan Zhou et al.   NATURE

Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation

(2016) Huanjiao Jenny Zhou et al.   NATURE MEDICINE

RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations

(2016) Robert Shenkar et al.   STROKE

CRTAM determines the CD4+cytotoxic T lymphocyte lineage

(2015) Arata Takeuchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

sRNAtoolbox: an integrated collection of small RNA research tools

(2015) Antonio Rueda et al.   NUCLEIC ACIDS RESEARCH

Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations

(2014) Robert Shenkar et al.   GENETICS IN MEDICINE

Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis

(2014) David A. McDonald et al.   HUMAN MOLECULAR GENETICS

Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-β

(2014) Lindsay B. Alcaraz et al.   JOURNAL OF CELL BIOLOGY

miRDB: an online resource for microRNA target prediction and functional annotations

(2014) Nathan Wong et al.   NUCLEIC ACIDS RESEARCH

EndMT contributes to the onset and progression of cerebral cavernous malformations

(2013) Luigi Maddaluno et al.   NATURE

Molecular mechanisms underlying RB protein function

(2013) Frederick A. Dick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of cell cycle transcription during G1 and S phases

(2013) Cosetta Bertoli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation

(2013) Ugo Moens et al.   Genes

An integrated view of cyclin E function and regulation

(2012) Ka Tat Siu et al.   CELL CYCLE

Untreated clinical course of cerebral cavernous malformations: a prospective, population-based cohort study

(2012) Rustam Al-Shahi Salman et al.   LANCET NEUROLOGY

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

Targeting inflammation by modulating the Jun/AP-1 pathway

(2011) H. B. Schonthaler et al.   ANNALS OF THE RHEUMATIC DISEASES

Endothelial paxillin and focal adhesion kinase (FAK) play a critical role in neutrophil transmigration

(2011) Sean A. Parsons et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Synergistic Roles for G-protein γ3and γ7Subtypes in Seizure Susceptibility as Revealed in Double Knock-out Mice

(2011) William F. Schwindinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impairment of Tight Junctions and Glucose Transport in Endothelial Cells of Human Cerebral Cavernous Malformations

(2011) Hannah Schneider et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans

(2011) J Pöschl et al.   ONCOGENE

Loss ofcerebral cavernous malformation 3(Ccm3) in neuroglia leads to CCM and vascular pathology

(2011) Angeliki Louvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGF164 differentially regulates neutrophil and T cell adhesion through ItgaL- and ItgaM-dependent mechanisms

(2010) John H. Chidlow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

KRIT1 Regulates the Homeostasis of Intracellular Reactive Oxygen Species

(2010) Luca Goitre et al.   PLoS One

Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling

(2010) Joycelyn Wüstehube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Rap1 and its effector KRIT1/CCM1 regulate  -catenin signaling

(2009) A. J. Glading et al.   Disease Models & Mechanisms

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

(2009) Kevin J Whitehead et al.   NATURE MEDICINE

Regulation of cardiovascular development and integrity by the heart of glass–cerebral cavernous malformation protein pathway

(2009) Benjamin Kleaveland et al.   NATURE MEDICINE

Excitation control: balancing PSD-95 function at the synapse

(2008) Dove Keith   Frontiers in Molecular Neuroscience