Synthetic Polyclonal-Derived CDR Peptides as an Innovative Strategy in Glaucoma Therapy

Neuroprotective and neuroregenerative effects of CRMP-5 on retinal ganglion cells in an experimental in vivo and in vitro model of glaucoma

(2019) Jasmin Lauzi et al.   PLoS One

Neuroprotection in glaucoma: recent advances and clinical translation

(2018) Chelsea Guymer et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Neuroprotective effects of erythropoietin on rat retinas subjected to oligemia

(2018) LA Carvalho et al.   Clinics

Proteomics Unravels the Regulatory Mechanisms in Human Tears Following Acute Renouncement of Contact Lens Use: A Comparison between Hard and Soft Lenses

(2018) Caroline Manicam et al.   Scientific Reports

Comparison of Two Solid-Phase Extraction (SPE) Methods for the Identification and Quantification of Porcine Retinal Protein Markers by LC-MS/MS

(2018) Carsten Schmelter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cross-linking mass spectrometry: methods and applications in structural, molecular and systems biology

(2018) Francis J. O’Reilly et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Peptides of the variable IgG domain as potential biomarker candidates in primary open-angle glaucoma (POAG)

(2017) Carsten Schmelter et al.   HUMAN MOLECULAR GENETICS

Ugi Reaction-Derived α-Acyl Aminocarboxamides Bind to Phosphatidylinositol 3-Kinase-Related Kinases, Inhibit HSF1-Dependent Heat Shock Response, and Induce Apoptosis in Multiple Myeloma Cells

(2017) Matthias Bach et al.   JOURNAL OF MEDICINAL CHEMISTRY

Decelerated neurodegeneration after intravitreal injection of α-synuclein antibodies in a glaucoma animal model

(2017) J. Teister et al.   Scientific Reports

Mitochondrial VDAC2 and cell homeostasis: highlighting hidden structural features and unique functionalities

(2016) Svetlana Rajkumar Maurya et al.   BIOLOGICAL REVIEWS

Neuroprotective effects of antibodies on retinal ganglion cells in an adolescent retina organ culture

(2016) Katharina Bell et al.   JOURNAL OF NEUROCHEMISTRY

Alterations in the expression of Hs1-associated protein X-1 in the rat retina after optic nerve crush

(2016) Ling Cui et al.   Molecular Medicine Reports

In-Depth Proteomic Analysis of the Porcine Retina by Use of a four Step Differential Extraction Bottom up LC MS Platform

(2016) Sebastian Funke et al.   MOLECULAR NEUROBIOLOGY

Glaucoma related Proteomic Alterations in Human Retina Samples

(2016) Sebastian Funke et al.   Scientific Reports

First insight into the proteome landscape of the porcine short posterior ciliary arteries: Key signalling pathways maintaining physiologic functions

(2016) Caroline Manicam et al.   Scientific Reports

AC-1001 H3 CDR peptide induces apoptosis and signs of autophagyin vitroand exhibits antimetastatic activity in a syngeneic melanoma model

(2016) Aline N. Rabaça et al.   FEBS Open Bio

Proteomics analysis of human tears from aqueous-deficient and evaporative dry eye patients

(2016) Natarajan Perumal et al.   Scientific Reports

Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration

(2015) Eliska Holzerova et al.   BRAIN

Regulation and function of the human HSP90AA1 gene

(2015) Abbey D. Zuehlke et al.   GENE

GFAP antibodies show protective effect on oxidatively stressed neuroretinal cells via interaction with ERP57

(2015) C. Wilding et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells

(2015) Andreas Kuehne et al.   MOLECULAR CELL

Characterization of human reflex tear proteome reveals high expression of lacrimal proline-rich protein 4 (PRR4)

(2015) Natarajan Perumal et al.   PROTEOMICS

Protective effect of 14-3-3 antibodies on stressed neuroretinal cells via the mitochondrial apoptosis pathway

(2015) Katharina Bell et al.   BMC Ophthalmology

Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy

(2014) Lucia Cilenti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Pathophysiology and Treatment of Glaucoma

(2014) Robert N. Weinreb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Anti-tumor activities of peptides corresponding to conserved complementary determining regions from different immunoglobulins

(2014) Carlos R. Figueiredo et al.   PEPTIDES

γ-Synuclein Antibodies Have Neuroprotective Potential on Neuroretinal Cells via Proteins of the Mitochondrial Apoptosis Pathway

(2014) Corina Wilding et al.   PLoS One

Peptides from the Variable Region of Specific Antibodies Are Shared among Lung Cancer Patients

(2014) Dominique de Costa et al.   PLoS One

Differential Antitumor Effects of IgG and IgM Monoclonal Antibodies and Their Synthetic Complementarity-Determining Regions Directed to New Targets of B16F10-Nex2 Melanoma Cells

(2014) Andrey S. Dobroff et al.   Translational Oncology

Selected autoantibodies and normal-tension glaucoma

(2014) Agnieszka Jamrozy-Witkowska   MEDICAL SCIENCE MONITOR

HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA

(2013) Hui-Gwan Goo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

HtrA Protease Family as Therapeutic Targets

(2013) Joanna Skorko-Glonek et al.   CURRENT PHARMACEUTICAL DESIGN

Cerebrospinal-fluid-derived Immunoglobulin G of Different Multiple Sclerosis Patients Shares Mutated Sequences in Complementarity Determining Regions

(2013) Vaibhav Singh et al.   MOLECULAR & CELLULAR PROTEOMICS

The Ubiquitin–Proteasome System in Retinal Health and Disease

(2013) Laura Campello et al.   MOLECULAR NEUROBIOLOGY

Does autoimmunity play a part in the pathogenesis of glaucoma?

(2013) Katharina Bell et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The Structural Basis of Antibody-Antigen Recognition

(2013) Inbal Sela-Culang et al.   Frontiers in Immunology

A novel role for the mitochondrial HTRA2/OMI protease in aging

(2012) Seokwon Kang et al.   Autophagy

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Antibody Constant Region Peptides Can Display Immunomodulatory Activity through Activation of the Dectin-1 Signalling Pathway

(2012) Elena Gabrielli et al.   PLoS One

Mass spectrometry analyses of κ and λ fractions result in increased number of complementarity-determining region identifications

(2011) Ingrid Broodman et al.   PROTEOMICS

Mitochondrial dysfunction in glaucoma and emerging bioenergetic therapies

(2010) Shanjean Lee et al.   EXPERIMENTAL EYE RESEARCH

Sequencing and Quantifying IgG Fragments and Antigen-Binding Regions by Mass Spectrometry

(2010) Dominique de Costa et al.   JOURNAL OF PROTEOME RESEARCH

Challenges in monoclonal antibody-based therapies

(2009) Haritha Samaranayake et al.   ANNALS OF MEDICINE

The serine protease HtrA2/Omi cleaves Parkin and irreversibly inactivates its E3 ubiquitin ligase activity

(2009) Hye-Min Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A tolerogenic peptide that induces suppressor of cytokine signaling (SOCS)-1 restores the aberrant control of IFN-γ signaling in lupus-affected (NZB×NZW)F1 mice

(2009) Amir Sharabi et al.   CLINICAL IMMUNOLOGY

The tolerogenic peptide hCDR1 downregulates pathogenic cytokines and apoptosis and upregulates immunosuppressive molecules and regulatory T cells in peripheral blood mononuclear cells of lupus patients

(2009) Zev M. Sthoeger et al.   HUMAN IMMUNOLOGY

Yeast Two-Hybrid, a Powerful Tool for Systems Biology

(2009) Anna Brückner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A New Model of Induced Experimental Systemic Lupus Erythematosus (SLE) in Pigs and Its Amelioration by Treatment with a Tolerogenic Peptide

(2009) Amir Sharabi et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Mitochondrial Dysfunction and Glaucoma

(2009) George Y. X. Kong et al.   JOURNAL OF GLAUCOMA

Antibody Complementarity-Determining Regions (CDRs): A Bridge between Adaptive and Innate Immunity

(2009) Elena Gabrielli et al.   PLoS One

A review on research progress of transketolase

(2009) Jing Zhao et al.   Neuroscience Bulletin

The mitochondrial serine protease HtrA2/Omi: an overview

(2008) L Vande Walle et al.   CELL DEATH AND DIFFERENTIATION

Antibody Complementarity-Determining Regions (CDRs) Can Display Differential Antimicrobial, Antiviral and Antitumor Activities

(2008) Luciano Polonelli et al.   PLoS One