Article
Medicine, General & Internal
Jamal S. Rana, Salim S. Virani, Howard H. Moffet, Jennifer Y. Liu, Landis A. Coghlan, Jitesh Vasadia, Christie M. Ballantyne, Andrew J. Karter
Summary: The study aimed to evaluate the association between outpatient LDL-C testing and subsequent statin adherence and intensification in patients after an ASCVD event. The results showed that LDL-C testing was associated with improved statin adherence and higher rates of treatment intensification.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ji Yoon Kim, Jimi Choi, Sin Gon Kim, Nam Hoon Kim
Summary: This study aimed to evaluate the optimal statin therapy for patients with type 2 diabetes. The findings suggest that the duration of statin therapy is as important or even more crucial than statin intensity or achieved LDL-C level in reducing cardiovascular risk. Longer treatment duration was associated with a lower risk of major adverse cardiovascular events. Adequate control of LDL-C levels with moderate to high-intensity statins also contributed to a lower cardiovascular risk.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Multidisciplinary Sciences
Akhil Sasidharan, Bhavani Shankara Bagepally, S. Sajith Kumar, Kayala Venkata Jagadeesh, Meenakumari Natarajan
Summary: The study found that Ezetimibe plus statin therapy is cost-effective compared to other lipid-lowering therapeutic agents or placebo in high-income countries and for primary prevention, but there is limited evidence from lower-middle-income countries and the societal perspective.
Article
Multidisciplinary Sciences
C. J. MacDonald, A. L. Madika, G. Severi, A. Fournier, M. C. Boutron-Ruault
Summary: The study found that non-O blood groups, particularly the A group, are associated with an increased risk of dyslipidaemia. Current smokers have a 30% higher risk of dyslipidaemia compared to never-smokers. These results could be useful for personalized approaches to preventing cardiovascular risk factors.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Jiahui Yan, Sisi Yang, Liang Han, Xin Ba, Pan Shen, Weiji Lin, Tingting Li, Ruiyuan Zhang, Ying Huang, Yao Huang, Kai Qin, Yu Wang, Shenghao Tu, Zhe Chen
Summary: This article describes the unique lipid profile of RA, explores the mechanisms underlying lipid changes, and investigates the impact of lipid changes on cardiovascular disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rui Gao, Kaixin Du, Jinhua Liang, Yi Xia, Jiazhu Wu, Yue Li, Bihui Pan, Li Wang, Jianyong Li, Wei Xu
Summary: This study aims to evaluate the prognostic value of cholesterol levels in CLL and develop a prognostic nomogram that incorporates lipid metabolism. The results showed that lower cholesterol levels at diagnosis were associated with worse prognosis, and post-therapeutic elevation of cholesterol levels correlated with better survival. Therefore, cholesterol profiles can be used as a cheap and readily accessible tool for predicting prognosis in CLL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Minji Ha, Jiyun Song, Sunkyoung Park, Kyungdo Han, Ho Sik Hwang, Hyun-Seung Kim, Reiko Arita, Kyung-Sun Na
Summary: The study found that patients with meibomian gland dysfunction (MGD) have significantly higher levels of high-density lipoprotein (HDL) and significantly lower levels of low-density lipoprotein (LDL) compared to the general population, although there was no difference in total cholesterol (TC) and triglycerides (TG) levels.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Chieh-Li Yen, Pei-Chun Fan, Cheng-Chia Lee, Jia-Jin Chen, George Kuo, Yi-Ran Tu, Pao-Hsien Chu, Hsiang-Hao Hsu, Ya-Chung Tian, Chih-Hsiang Chang
Summary: This study evaluated the cardiovascular and renal outcomes in patients with stage 3 chronic kidney disease with different LDL-C levels during statin treatment. Patients with LDL-C levels between 70-100 mg/dL had lower risks of major adverse cardiac and cerebrovascular events and new-onset end-stage renal disease requiring chronic dialysis compared to other LDL-C groups.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Urology & Nephrology
Arata Osanami, Marenao Tanaka, Masato Furuhashi, Hirofumi Ohnishi, Nagisa Hanawa, Tomohisa Yamashita, Norihito Moniwa, Tetsuji Miura
Summary: This study examines the relationship between serum lipid levels and the time course of renal function in a cohort of healthy subjects. The findings suggest that a high LDL-C level may be a risk factor for new-onset chronic kidney disease in apparently healthy males.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Xin Zhao, Jianbin Sun, Sixu Xin, Xiaomei Zhang
Summary: This study analyzed the association between blood lipid metabolism and osteoporosis (OP) in older adults with type 2 diabetes mellitus (T2DM). The results showed that higher levels of low-density lipoprotein cholesterol (LDL-C) were associated with OP, while higher levels of high-density lipoprotein cholesterol (HDL-C) were associated with non-osteoporotic patients. Age, parathyroid hormone (PTH), total cholesterol (TC), and LDL-C were negatively linked to bone mineral density (BMD), while body mass index (BMI), uric acid (UA) level, HDL-C level, and glomerular filtration rate (eGFR) were positively related to BMD. In postmenopausal women, raised LDL-C was an independent risk factor for OP, while raised HDL-C was protective. Conclusion: Blood lipid levels are related to sex in older T2DM patients, with HDL-C being a protective factor for OP in both men and women, and LDL-C being a predictor for OP in postmenopausal women.
Article
Cardiac & Cardiovascular Systems
Kazuma Oyama, Robert P. Giugliano, Michael A. Blazing, Jeong-Gun Park, Andrew M. Tershakovec, Marc S. Sabatine, Christopher P. Cannon, Eugene Braunwald
Summary: The study found that adding ezetimibe to statin therapy consistently reduced the risk of cardiovascular events in post-ACS patients, regardless of baseline LDL-C values, supporting the use of intensive lipid-lowering therapy with ezetimibe even in patients with baseline LDL-C <70 mg/dL.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Nutrition & Dietetics
Rebeca Quiros-Fernandez, Bricia Lopez-Plaza, Laura M. Bermejo, Samara Palma Milla, Andrea Zangara, Carmen Gomez Candela
Summary: The supplement containing HT and PC showed significant improvement in dyslipidemia, indicating its potential for preventing atherosclerosis and protecting the heart in adults.
Article
Pharmacology & Pharmacy
Enchen Zhou, Zhuang Li, Hiroyuki Nakashima, Ahlam Choukoud, Sander Kooijman, Jimmy F. P. Berbee, Patrick C. N. Rensen, Yanan Wang
Summary: Accelerating lipolytic processing of VLDL by brown fat activation can further lower (V)LDL levels and reduce the risk of atherosclerosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Ciaran N. Kohli-Lynch, Brandon K. Bellows, Yiyi Zhang, Bonnie Spring, Dhruv S. Kazi, Mark J. Pletcher, Eric Vittinghoff, Norrina B. Allen, Andrew E. Moran
Summary: The study revealed that around 27% of ASCVD-free young adults in the United States have LDL-C levels >_130 mg/dL, and 9% have LDL-C >_160 mg/dL. Using statins or lifestyle interventions for lipid-lowering can prevent ASCVD events and increase QALYs compared to standard care.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Peripheral Vascular Disease
Daiji Nagayama, Atsuhito Saiki, Yasuhiro Watanabe, Takashi Yamaguchi, Masahiro Ohira, Naoko Sato, Mizuho Kanayama, Masao Moroi, Yoh Miyashita, Kohji Shirai, Ichiro Tatsuno
Summary: This study investigated the mechanism by which pitavastatin reduces cardiovascular events more effectively than atorvastatin. The results showed that despite similar LDL cholesterol-lowering effects, pitavastatin was more effective in reducing cardiovascular events. Furthermore, pitavastatin treatment increased LPL mass during the first year, which may be associated with its efficacy.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Article
Peripheral Vascular Disease
Nathalie Moise, Chen Huang, Anthony Rodgers, Ciaran N. Kohli-Lynch, Keane Y. Tzong, Pamela G. Coxson, Kirsten Bibbins-Domingo, Lee Goldman, Andrew E. Moran
Article
Nutrition & Dietetics
Cindy M. Gray, Sally Wyke, Ruiqi Zhang, Annie S. Anderson, Sarah Barry, Nicki Boyer, Graham Brennan, Andrew Briggs, Christopher Bunn, Craig Donnachie, Eleanor Grieve, Ciaran Kohli-Lynch, Suzanne M. Lloyd, Alex McConnachie, Colin McCowan, Alice MacLean, Nanette Mutrie, Kate Hunt
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2018)
Article
Medicine, General & Internal
L. Chola, K. MacQuilkan, A. Winch, R. Rapiti, I. Edoka, C. Kohli-Lynch, K. Hofman
SAMJ SOUTH AFRICAN MEDICAL JOURNAL
(2019)
Article
Medical Laboratory Technology
Ciaran N. Kohli-Lynch, George Thanassoulis, Andrew E. Moran, Allan D. Sniderman
CLINICA CHIMICA ACTA
(2020)
Article
Immunology
Ijeoma Edoka, Ciaran Kohli-Lynch, Heather Fraser, Karen Hofman, Stefano Tempia, Meredith McMorrow, Wayne Ramkrishna, Philipp Lambach, Raymond Hutubessy, Cheryl Cohen
Summary: The seasonal influenza vaccination strategy in South Africa is cost-effective for vulnerable populations, except for children aged 6-59 months. The highest number of clinical events are averted in persons living with HIV/AIDS and persons with underlying medical conditions.
Letter
Health Care Sciences & Services
Ciaran N. Kohli-Lynch, Natalia Ruiz-Negron, Amy Beal, Brandon K. Bellows
JOURNAL OF MANAGED CARE & SPECIALTY PHARMACY
(2021)
Article
Cardiac & Cardiovascular Systems
Ciaran N. Kohli-Lynch, Brandon K. Bellows, Yiyi Zhang, Bonnie Spring, Dhruv S. Kazi, Mark J. Pletcher, Eric Vittinghoff, Norrina B. Allen, Andrew E. Moran
Summary: The study revealed that around 27% of ASCVD-free young adults in the United States have LDL-C levels >_130 mg/dL, and 9% have LDL-C >_160 mg/dL. Using statins or lifestyle interventions for lipid-lowering can prevent ASCVD events and increase QALYs compared to standard care.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Economics
Yiqiao Xin, Ewan Gray, Jose Antonio Robles-Zurita, Houra Haghpanahan, Robert Heggie, Ciaran Kohli-Lynch, Andrew Briggs, David A. McAllister, Kenny D. Lawson, Jim Lewsey
Summary: This study discusses the process of converting the Scottish Cardiovascular Disease policy model from Excel to R, finding that R model has higher computational efficiency and is feasible for health economists to use. However, using health economics specialist packages to develop the model may face adaptability issues, and the conversion process needs to maintain transparency and replicability.
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2022)
Review
Health Policy & Services
Katherine Zheng, Brocha Z. Stern, Q. Eileen Wafford, Ciaran N. Kohli-Lynch
Summary: This study aimed to identify, appraise, and summarize outcomes reported in trial-based economic evaluations of Individual Placement and Support programs. Seven studies were included in the review, indicating that Individual Placement and Support may be a cost-effective alternative to traditional vocational rehabilitation programs. However, factors such as geographical location need to be considered when interpreting economic outcomes.
ADMINISTRATION AND POLICY IN MENTAL HEALTH AND MENTAL HEALTH SERVICES RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Ciaran N. Kohli-Lynch, James Lewsey, Kathleen A. Boyd, Dustin D. French, Neil Jordan, Andrew E. Moran, Naveed Sattar, David Preiss, Andrew H. Briggs
Summary: This study evaluates the cost-effectiveness of expanding preventive statin eligibility and novel approaches to prioritization from a Scottish health sector perspective. The findings suggest that generic pricing has made preventive statin therapy cost-effective for many adults. Additionally, an approach using absolute risk reduction (ARR)-guided therapy is more effective and cost-effective than the traditional method based on 10-year risk assessment.
Article
Infectious Diseases
Heather Fraser, Winfrida Tombe-Mdewa, Ciaran Kohli-Lynch, Karen Hofnnan, Stefano Tennpia, Meredith McMorrow, Philipp Lambach, Wayne Ramkrishna, Cheryl Cohen, Raymond Hutubessy, Ijeoma Edoka
Summary: The South African National Department of Health introduced a trivalent inactivated influenza vaccination programme in 2010 to address the burden of influenza. By estimating the costs and conducting scenario analyses, we provide estimates of the total costs of the programme, which can serve as a basis for future programme expansion and cost-effectiveness analyses.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2022)
Article
Public, Environmental & Occupational Health
Micheal Kofi Boachie, Evelyn Thsehla, Mustapha Immurana, Ciaran Kohli-Lynch, Karen J. Hofman
Summary: Overweight and obesity impose a significant financial burden on the public healthcare system in South Africa, with an estimated total cost of ZAR33,194 million in 2020. This represents 15.38% of government health expenditure and 0.67% of GDP. The findings emphasize the urgent need for preventive, population-level interventions to reduce the incidence and healthcare spending on overweight and obesity-related diseases.
GLOBAL HEALTH ACTION
(2022)
Article
Peripheral Vascular Disease
Matthew B. Green, Daichi Shimbo, Joseph E. Schwartz, Adam P. Bress, Jordan B. King, Paul Muntner, James P. Sheppard, Richard J. McManus, Ciaran N. Kohli-Lynch, Yiyi Zhang, Steven Shea, Andrew E. Moran, Brandon K. Bellows
Summary: Screening and treating masked hypertension using ambulatory blood pressure monitoring (ABPM) is cost-effective for US adults with suspected masked hypertension.
AMERICAN JOURNAL OF HYPERTENSION
(2022)