A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control

A Synthetic DNA, Multi-Neoantigen Vaccine Drives Predominately MHC Class I CD8+ T-cell Responses, Impacting Tumor Challenge

(2019) Elizabeth K. Duperret et al.   Cancer Immunology Research

Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8+ T Cells in Murine Syngeneic Tumor Models

(2019) Huizhong Xiong et al.   Cancer Immunology Research

Personalized neoantigen vaccines: A new approach to cancer immunotherapy

(2018) Amanda R. Aldous et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations

(2018) Judith A. Seidel et al.   Frontiers in Oncology

Cationic Liposomes: A Flexible Vaccine Delivery System for Physicochemically Diverse Antigenic Peptides

(2018) Jeroen Heuts et al.   PHARMACEUTICAL RESEARCH

A non-functional neoepitope specific CD8+ T-cell response induced by tumor derived antigen exposure in vivo

(2018) Mathias Vormehr et al.   OncoImmunology

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy

(2017) Jan Willem Kleinovink et al.   OncoImmunology

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines

(2015) John J. Suschak et al.   JOURNAL OF IMMUNOLOGY

Mutant MHC class II epitopes drive therapeutic immune responses to cancer

(2015) Sebastian Kreiter et al.   NATURE

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

(2015) B. M. Carreno et al.   SCIENCE

Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia

(2014) M. Rajasagi et al.   BLOOD

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

(2014) Mahesh Yadav et al.   NATURE

Exploiting the Mutanome for Tumor Vaccination

(2012) J. C. Castle et al.   CANCER RESEARCH

IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques

(2012) Rashmi Jalah et al.   Human Vaccines & Immunotherapeutics

DNA Vaccines: Developing New Strategies against Cancer

(2010) Daniela Fioretti et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Naive tumor-specific CD4+T cells differentiated in vivo eradicate established melanoma

(2010) Ying Xie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Directly Transfected Langerin+ Dermal Dendritic Cells Potentiate CD8+ T Cell Responses following Intradermal Plasmid DNA Immunization

(2010) M. Elnekave et al.   JOURNAL OF IMMUNOLOGY

Immune response induced by a linear DNA vector: Influence of dose, formulation and route of injection

(2010) Anne Endmann et al.   VACCINE

Construction of an HBV DNA vaccine by fusion of the GM-CSF gene to the HBV-S gene and examination of its immune effects in normal and HBV-transgenic mice

(2010) Yuling Qing et al.   VACCINE

Equivalent stimulation of naive and memory CD8 T cells by DNA vaccination: a dendritic cell-dependent process

(2009) Sammy Bedoui et al.   IMMUNOLOGY AND CELL BIOLOGY

Induction of T cell-mediated immunity using a c-Myb DNA vaccine in a mouse model of colon cancer

(2008) Benjamin B. Williams et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY