IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques

Therapeutic Vaccination with Simian Immunodeficiency Virus (SIV)-DNA+IL-12 or IL-15 Induces Distinct CD8 Memory Subsets in SIV-Infected Macaques

(2014) R. Halwani et al.   JOURNAL OF IMMUNOLOGY

CD4+CD8+ T Cells Represent a Significant Portion of the Anti-HIV T Cell Response to Acute HIV Infection

(2012) M. A. Frahm et al.   JOURNAL OF IMMUNOLOGY

Safety and Immunogenicity of an HIV-1 Gag DNA Vaccine with or without IL-12 and/or IL-15 Plasmid Cytokine Adjuvant in Healthy, HIV-1 Uninfected Adults

(2012) Spyros A. Kalams et al.   PLoS One

New Paradigms for HIV/AIDS Vaccine Development

(2011) Louis J. Picker et al.   Annual Review of Medicine

IL-12 selectively programs effector pathways that are stably expressed in human CD8+ effector memory T cells in vivo

(2011) F. Z. Chowdhury et al.   BLOOD

Electroporation delivery of DNA vaccines: prospects for success

(2011) Niranjan Y Sardesai et al.   CURRENT OPINION IN IMMUNOLOGY

Enhanced Control of Pathogenic Simian Immunodeficiency Virus SIVmac239 Replication in Macaques Immunized with an Interleukin-12 Plasmid and a DNA Prime-Viral Vector Boost Vaccine Regimen

(2011) N. Winstone et al.   JOURNAL OF VIROLOGY

Distinct CD4+CD8+ Double-Positive T Cells in the Blood and Liver of Patients during Chronic Hepatitis B and C

(2011) Michelina Nascimbeni et al.   PLoS One

In Vivo Electroporation Enhances the Immunogenicity of an HIV-1 DNA Vaccine Candidate in Healthy Volunteers

(2011) Sandhya Vasan et al.   PLoS One

DNA/Ad5 vaccination with SIV epitopes induced epitope-specific CD4+ T cells, but few subdominant epitope-specific CD8+ T cells

(2011) Lara Vojnov et al.   VACCINE

Selected approaches for increasing HIV DNA vaccine immunogenicity in vivo

(2011) Natalie A Hutnick et al.   Current Opinion in Virology

Unique Th1/Th2 Phenotypes Induced during Priming and Memory Phases by Use of Interleukin-12 (IL-12) or IL-28B Vaccine Adjuvants in Rhesus Macaques

(2010) M. P. Morrow et al.   Clinical and Vaccine Immunology

Natural Suppression of Human Immunodeficiency Virus Type 1 Replication Is Mediated by Transitional Memory CD8+ T Cells

(2010) M. S. Killian et al.   JOURNAL OF VIROLOGY

Multiple Vaccine-Elicited Nonneutralizing Antienvelope Antibody Activities Contribute to Protective Efficacy by Reducing both Acute and Chronic Viremia following Simian/Human Immunodeficiency Virus SHIV89.6P Challenge in Rhesus Macaques

(2010) P. Xiao et al.   JOURNAL OF VIROLOGY

Phase 1 Safety and Immunogenicity Evaluation of ADVAX, a Multigenic, DNA-Based Clade C/B' HIV-1 Candidate Vaccine

(2010) Sandhya Vasan et al.   PLoS One

Long-lasting humoral and cellular immune responses and mucosal dissemination after intramuscular DNA immunization

(2010) Vainav Patel et al.   VACCINE

Repeated DNA therapeutic vaccination of chronically SIV-infected macaques provides additional virological benefit

(2010) Antonio Valentin et al.   VACCINE

Comparison of immune responses generated by optimized DNA vaccination against SIV antigens in mice and macaques

(2010) Viraj Kulkarni et al.   VACCINE

Phenotypic and Functional Characterization of HIV-1-Specific CD4+CD8+ Double-Positive T Cells in Early and Chronic HIV-1 Infection

(2009) Rawleigh Howe et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1

(2009) Brandon F. Keele et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

(2009) Scott G Hansen et al.   NATURE MEDICINE

DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge

(2009) M. Rosati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discordant memory B cell and circulating anti-Env antibody responses in HIV-1 infection

(2009) Y. Guan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of DNA vaccines producing HIV-1 Gag and LAMP/Gag chimera in rhesus macaques reveals antigen-specific T-cell responses with distinct phenotypes

(2009) Antonio Valentin et al.   VACCINE

Increased immune responses in rhesus macaques by DNA vaccination combined with electroporation

(2008) Margherita Rosati et al.   VACCINE

Comparative ability of various plasmid-based cytokines and chemokines to adjuvant the activity of HIV plasmid DNA vaccines

(2008) Rong Xu et al.   VACCINE

Combined effects of IL-12 and electroporation enhances the potency of DNA vaccination in macaques

(2008) Lauren A. Hirao et al.   VACCINE