Article
Chemistry, Multidisciplinary
Khalida Fakhruddin, Rozita Hassan, Muhammad Umar Aslam Khan, Sabrina Naula Allisha, Saiful Izwan Abd Razak, Maen Hussni Zreaqat, Hadafi Fitri Mohd Latip, Mohd Najeb Jamaludin, Anwarul Hassan
Summary: Halloysite nanotubes (HNTs), as a natural material, have unique properties that make them ideal for biomedical applications, such as loading bioactive molecules and therapeutic agents. The review paper covers the characterizations, properties, and applications of HNTs-polymer nanocomposites in biomedical fields, providing an overview of their potential in personalized medicine and drug delivery methods for researchers developing novel biomaterials in biomedical engineering and health care.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Huan Gao, Miguel A. Soto, Zongzhe Li, Lucas J. Andrew, Mark J. Maclachlan
Summary: Scientists developed new aerogel sorbents by combining halloysite nanotubes and cellulose nanocrystals, and these materials effectively remove dyes from water. They are environmentally friendly, cost-effective, and have potential for water remediation.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Physical
Fulya Taktak, Ayse Pinar Turgut Yigen
Summary: Co-administration of two or more drugs has been shown to be a viable option for treating diseases such as rheumatoid arthritis. Different kinetic models were studied to fit single and combined drug release kinetics.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Ofer Prinz Setter, Lisa Dahan, Hanan Abu Hamad, Ester Segal
Summary: Clay minerals, especially Halloysite nanotubes (HNT), have shown great potential in drug delivery due to their mesoporous tubular nanostructure and high adsorption capacity. Acid etching of HNT increases their loading potential by increasing specific surface area and porosity. This study demonstrates that etched HNT (E-HNT) outperforms pristine HNT in terms of loading capacity and antibacterial effect when used as a carrier for the antibiotic ciprofloxacin (CIP).
APPLIED CLAY SCIENCE
(2022)
Article
Chemistry, Physical
Meng Fu, Wantong Chen, Haojun Deng, Chunhui Chen, Zhikang Fan, Binyu Li, Xiangming Li
Summary: Hal-based aerogels with anisotropic mechanical properties were successfully prepared, showing low thermal conductivities, good thermal stabilities, and flame retardancy. The study provides a versatile method for designing and fabricating high-performance thermal insulation materials aerogels, and has significance in the high-value utilization of Hal mineral resources.
APPLIED CLAY SCIENCE
(2022)
Article
Polymer Science
Sophie Groult, Sytze Buwalda, Tatiana Budtova
Summary: Porous pectin matrices, including cryogels, aerogels, and xerogels, were prepared using different drying methods in this study. The physico-chemical properties of these matrices and the release of theophylline were investigated. The results indicate that porous pectin matrices have great potential for drug delivery purposes.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Physical
Xinyu Lei, Yi Zhou, Xianhao Liu, Lingchang Kong, Libing Liao, Yuxin Li, Meng Liu, Lintao Tian, Wenxiu Rao, Guocheng Lv
Summary: In this study, a drug nanocarrier with effective pH-responsive properties based on natural halloysite nanotubes (Hal) was designed and investigated. The anisotropic surfaces of Hal allow for diverse charges under different pH, enabling electrostatic attraction or repulsion between the nanocarrier and drug molecules. Chitosan and pectin were self-assembled on Hal through electrostatic attraction to achieve dual encapsulation and pH-responsive drug release in the gut.
APPLIED CLAY SCIENCE
(2023)
Article
Polymer Science
Zhongming Liu, Sufeng Zhang, Chao Gao, Xia Meng, Shoujuan Wang, Fangong Kong
Summary: Temperature/pH-responsive CMC/Ca2+/PNIPAM aerogels were developed as a novel drug delivery system. The aerogels have a highly open network structure and multiple active sites, making them suitable for drug loading and sustained release. Characterization of the aerogels confirmed their non-toxicity and good temperature and pH response performance.
Article
Biotechnology & Applied Microbiology
Reza Taheri-Ledari, Wenjie Zhang, Maral Radmanesh, Nicole Cathcart, Ali Maleki, Vladimir Kitaev
Summary: The study utilized natural halloysite nanotubes as a carrier and achieved selective release through gold nanoparticles, successfully targeting ovarian tumors. The developed DTX@HNT/Au-SORT nanocomposite demonstrated efficient antitumor activity, enabling selective drug release to tumor cells through photothermal therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Physical
Fuxing Zhao, Jundong Zhu, Tangping Peng, Hao Liu, Shengzhuo Ge, Huasheng Xie, Le Xie, Chongwen Jiang
Summary: The novel polyimide composite aerogel synthesized using functionalized clay halloysite nanotubes showed excellent thermal stability, low density, and high mechanical property, making it a promising thermal management material for practical and complex insulation applications.
APPLIED CLAY SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Fangxin Zou, Tatiana Budtova
Summary: In this study, different forms of starch (alcogels, aerogels, and xerogels) were designed and tested as carriers of theophylline in pharmaceutical applications. The influence of starch properties and drying methods on material characteristics was investigated, and a new method for making aerogel-like polysaccharide materials without supercritical drying was proposed. The results demonstrate the potential of these materials as drug carriers.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Ajmal Zarinwall, Viktor Maurer, Jennifer Pierick, Victor Marcus Oldhues, Julian Cedric Porsiel, Jan Henrik Finke, Georg Garnweitner
Summary: This study investigated the use of mesoporous silica aerogels (SA) as a carrier matrix for improving the solubility and release behavior of poorly water-soluble drugs. By utilizing post-synthetic loading methods and surface modification, the interaction properties between SA and the drug were selectively tuned. The results showed that the chemical surface properties of SA, formulation-related parameters, and process-related parameters significantly influenced the drug adsorption efficiency and stability. The findings demonstrate that specifically processed and modified SA offer a compelling technique for enhancing the bioavailability of poorly water-soluble APIs and adjusting their release profile.
Article
Engineering, Environmental
Guopeng Teng, Chaowen Chen, Nana Jing, Chuang Chen, Yajun Duan, Lihong Zhang, Zhengyan Wu, Jia Zhang
Summary: In this study, a novel responsive material with acid/alkali dual pH sensitivity was developed for the delivery of hydrophobic pesticides. The material exhibited high loading capacity and efficiency, and demonstrated sustained release behavior at different pH values. Additionally, the material showed improved foliar adhesion properties and excellent stability under high temperature and UV irradiation conditions.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Shu-Ting Liu, Xue-Gang Chen, Shi-Long Zhang, Xue-Min Liu, Jun-Ji Zhang
Summary: Chemical modification of halloysite nanotubes can improve the loading and sustained release of quercetin, with potential applications for drug delivery systems. Among the five reagents tested, sodium lauroamphoacetate showed the highest loading capacity while cocamidopropyl betaine exhibited the best sustained-release profile.
CLAYS AND CLAY MINERALS
(2021)
Article
Chemistry, Physical
Shubhankar Dube, Deepak Rawtani, Nitasha Khatri, Garvita Parikh
Summary: This article comprehensively reviews the potential and issues of HNTs as drug carriers, and discusses their safety across different cell lines and model organisms. Furthermore, it provides insights into the impact of HNTs' surface chemistry and release kinetics on therapeutic efficacy, as well as unexplored areas in current research.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
