Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation

Assessing arthritis in the context of cystic fibrosis

(2019) Elizabeth A. Clarke et al.   PEDIATRIC PULMONOLOGY

Inositol-Requiring Enzyme 1-Mediated Downregulation of MicroRNA (miR)-146a and miR-155 in Primary Dermal Fibroblasts across Three TNFRSF1A Mutations Results in Hyperresponsiveness to Lipopolysaccharide

(2018) Stephanie R. Harrison et al.   Frontiers in Immunology

Differential expression of genes and receptors in monocytes from patients with cystic fibrosis

(2018) Abdullah A. Tarique et al.   Journal of Cystic Fibrosis

IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

(2018) Minkyung Song et al.   NATURE

Cystic fibrosis transmembrane conductance regulator (CFTR) modulators have differential effects on cystic fibrosis macrophage function

(2018) Shuzhong Zhang et al.   Scientific Reports

Impact of CFTR modulation with Ivacaftor on Gut Microbiota and Intestinal Inflammation

(2018) Chee Y. Ooi et al.   Scientific Reports

Role of IRE1α/XBP-1 in Cystic Fibrosis Airway Inflammation

(2017) Carla Ribeiro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosis

(2017) Abdullah A. Tarique et al.   Journal of Cystic Fibrosis

The impact of impaired macrophage functions in cystic fibrosis disease progression

(2017) Manuella Lévêque et al.   Journal of Cystic Fibrosis

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

The burgeoning field of innate immune-mediated disease and autoinflammation

(2016) Daniel Peckham et al.   JOURNAL OF PATHOLOGY

XBP1: A Pivotal Transcriptional Regulator of Glucose and Lipid Metabolism

(2016) Christina Piperi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

X-Box–Binding Protein 1 and Innate Immune Responses of Human Cystic Fibrosis Alveolar Macrophages

(2015) Bob A. Lubamba et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pancreatic pathophysiology in cystic fibrosis

(2015) Katherine N Gibson-Corley et al.   JOURNAL OF PATHOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Cystic fibrosis: Evidence for gut inflammation

(2014) Anne Munck   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Physiological roles of regulated Ire1 dependent decay

(2014) Dina S. Coelho et al.   Frontiers in Genetics

Impaired Functions of Macrophage from Cystic Fibrosis Patients: CD11b, TLR-5 Decrease and sCD14, Inflammatory Cytokines Increase

(2013) Karin Simonin-Le Jeune et al.   PLoS One

Involvement of X-box binding protein 1 and reactive oxygen species pathways in the pathogenesis of tumour necrosis factor receptor-associated periodic syndrome

(2012) Laura J Dickie et al.   ANNALS OF THE RHEUMATIC DISEASES

XBP1mRNA Splicing Triggers an Autophagic Response in Endothelial Cells throughBECLIN-1Transcriptional Activation

(2012) Andriana Margariti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atypical Activation of the Unfolded Protein Response in Cystic Fibrosis Airway Cells Contributes to p38 MAPK-Mediated Innate Immune Responses

(2012) C. J. Blohmke et al.   JOURNAL OF IMMUNOLOGY

Absence of the cystic fibrosis transmembrane regulator (Cftr ) from myeloid-derived cells slows resolution of inflammation and infection

(2012) T. L. Bonfield et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

New animal models of cystic fibrosis

(2011) Nicholas W. Keiser et al.   CURRENT OPINION IN PULMONARY MEDICINE

Dysfunctional CFTR Alters the Bactericidal Activity of Human Macrophages against Pseudomonas aeruginosa

(2011) Paola Del Porto et al.   PLoS One

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Monocytes from children with clinically stable cystic fibrosis show enhanced expression of Toll-like receptor 4

(2010) Nina C. Sturges et al.   PEDIATRIC PULMONOLOGY

Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth

(2010) D. A. Stoltz et al.   Science Translational Medicine

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY