Article
Multidisciplinary Sciences
Masaki Sasai
Summary: This study investigates the molecular synchronization mechanism of the circadian clock in cyanobacteria, proposing a theoretical model that considers multiple feedback relationships and interactions between KaiA, KaiB, and KaiC. The model suggests that biochemical assays with varying concentrations of KaiA or KaiB can be used to test the synchronization mechanism.
SCIENTIFIC REPORTS
(2021)
Article
Psychiatry
Hadar Naftalovich, Gideon E. Anholt, Rotem Keren, Oded Ben Arush, Eyal Kalanthroff
Summary: This study examined the relationship between alertness and OCD symptom severity fluctuations throughout the day, finding that individuals with an evening preference tended to have worse symptoms in the morning, and vice versa. The findings suggest that alertness may modulate OCD symptom severity, with individuals experiencing more severe symptoms during times of low alertness.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Endocrinology & Metabolism
Yin Jiang, Shiping Li, Wenming Xu, Junjie Ying, Yi Qu, Xiaohui Jiang, Ayuan Zhang, Yan Yue, Ruixi Zhou, Tiechao Ruan, Jinhui Li, Dezhi Mu
Summary: BMAL1 plays a vital role in reproductive physiology, as its knockout results in infertility in mice, with impaired reproductive organs, hormone secretion and signaling, and gonadal steroidogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Psychiatry
Zhi Xu, Lei Chen, Yunyun Hu, Tian Shen, Zimu Chen, Tingting Tan, Chenjie Gao, Suzhen Chen, Wenji Chen, Bingwei Chen, Yonggui Yuan, Zhijun Zhang
Summary: The study found that factors such as age of onset, suicide attempts, and hospitalizations are associated with MDD-to-BD conversion, and established a predictive model with specific guiding significance for clinical diagnosis.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Maria A. Kozlova, Yuri A. Kirillov, Lyudmila A. Makartseva, Igor Chernov, David A. Areshidze
Summary: The study revealed that chronic alcohol intoxication and constant illumination have significant effects on the rat liver structure and circadian rhythms, with their combined effects being the most profound. These factors disrupt micromorphometric parameters of hepatocytes, protein levels, enzymes, and bilirubin rhythms, as well as impacting the expression and rhythmicity of clock genes in the context of liver inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maria Luz Alonso-Alonso, Ana Sampedro-Viana, Manuel Rodriguez-Yanez, Iria Lopez-Dequidt, Jose M. Pumar, Antonio J. Mosqueira, Sabela Fernandez-Rodicio, Marcos Bazarra-Barreiros, Tomas Sobrino, Francisco Campos, Jose Castillo, Pablo Hervella, Ramon Iglesias-Rey
Summary: The circadian system has an influence on body temperature and stroke onset. This study explores the impact of temperature chronobiology on stroke onset and functional outcomes, as well as the variation of blood biomarkers based on stroke onset time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marta Budkowska, Elzbieta Cecerska-Heryc, Zuzanna Marcinowska, Aldona Siennicka, Barbara Dolegowska
Summary: This study aimed to investigate the activity of several enzymes related to oxidative stress and the concentration of glutathione in the circadian rhythm. The results showed that the activity of these enzymes and the concentration of glutathione peaked at 2 a.m. during sleep. This suggests that the processes maintaining the redox balance are intensified during sleep, thus reducing oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Yufei Liu, Long Niu, Xinyao Liu, Cheng Cheng, Weidong Le
Summary: Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by both motor and non-motor symptoms, with circadian rhythm dysregulation emerging as a key feature that may play a pivotal role in the pathogenesis of PD. Recent research progress has focused on understanding altered circadian rhythm in PD, from clinical manifestations to underlying causes of circadian disorders in PD.
NEUROSCIENCE BULLETIN
(2021)
Review
Endocrinology & Metabolism
Si-Ke He, Jia-Hao Wang, Tao Li, Shan Yin, Jian-Wei Cui, Yun-Fei Xiao, Yin Tang, Jia Wang, Yun-Jin Bai
Summary: This article reviews the relationship between circadian rhythm disturbance and kidney stone disease (KSD), summarizing the risk factors and treatment methods. The results indicate that KSD is associated with systemic disorders such as metabolic syndrome, inflammatory bowel disease, and microbiome dysbiosis, and some chronotherapies have been proven effective.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Neurosciences
Elena Gangitano, Lucio Gnessi, Andrea Lenzi, David Ray
Summary: Circadian rhythms play a crucial role in physiological processes and are influenced by light-dark cycles and food intake. Misalignment of circadian clocks may lead to metabolic diseases, highlighting the significance of diet and fasting on clock regulation.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Adam J. Webb, Emily Harper, Tim Rattay, Miguel E. Aguado-Barrera, David Azria, Celine Bourgier, Muriel Brengues, Erik Briers, Renee Bultijnck, Jenny Chang-Claude, Ananya Choudhury, Alessandro Cicchetti, Dirk De Ruysscher, Maria Carmen De Santis, Alison M. Dunning, Rebecca M. Elliott, Laura Fachal, Antonio Gomez-Caamano, Sara Gutierrez-Enriquez, Kerstie Johnson, Ramon Lobato-Busto, Sarah L. Kerns, Giselle Post, Tiziana Rancati, Victoria Reyes, Barry S. Rosenstein, Petra Seibold, Alejandro Seoane, Paloma Sosa-Fajardo, Elena Sperk, Begona Taboada-Valladares, Riccardo Valdagni, Ana Vega, Liv Veldeman, Tim Ward, Catharine M. West, R. Paul Symonds, Christopher J. Talbot
Summary: The study investigated the impact of genotypes and treatment timing on toxicity after breast cancer radiotherapy, revealing significant effects of the interaction between treatment time and genotypes on toxicity.
Review
Biochemistry & Molecular Biology
Li-Ping Liu, Meng-Huan Li, Yun-Wen Zheng
Summary: Clock genes in hair follicles are regulated by both the central circadian system and external factors such as light and thyroid hormones. They play a role in regulating physiological processes of hair follicles, including hair growth and pigmentation. Hair follicles can serve as a noninvasive method for monitoring circadian-rhythm-related conditions in humans, and combining hair follicle sampling with other assays can improve their applications. Hair follicles provide insights into potential mechanisms of circadian-rhythm-related conditions and can support personalized treatment scheduling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Pharmacology & Pharmacy
Lukasz Dobrek
Summary: The optimization of pharmacotherapy aims for maximum individualization to ensure effectiveness and safety for the patient. Factors such as patient characteristics, polypharmacotherapy, genotyping, and TDM monitoring are crucial considerations. Chronopharmacology is also an important but often overlooked factor in drug therapy.
Article
Clinical Neurology
Himanshu K. Mishra, Heather Wei, Kayla E. Rohr, Insu Ko, Caroline M. Nievergelt, Adam X. Maihofer, Paul D. Shilling, Martin Alda, Wade H. Berrettini, Kristen J. Brennand, Joseph R. Calabrese, William H. Coryell, Mark Frye, Fred Gage, Elliot Gershon, Melvin G. McInnis, John Nurnberger, Ketil J. Oedegaard, Peter P. Zandi, John R. Kelsoe, Michael J. McCarthy
Summary: Bipolar disorder (BD) is characterized by mood episodes, disrupted circadian rhythms, and gray matter reduction in the brain. Lithium, an effective pharmacotherapy for BD, has neuroprotective properties and beneficial effects on circadian rhythms that may distinguish lithium responders (Li-R) from non-responders (Li-NR). Patterns of co-expression among circadian clock and cell survival genes were found in BD patients and controls, as well as in Li-R vs. Li-NR cells. The coordination between circadian clock and cell survival genes in BD may help predict lithium response.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Y. Xie, Q. Tang, S. Yu, W. Zheng, G. Chen, X. Huang, L. Chen
Summary: BMAL1 in PDLCs plays a crucial role in sensing and transmitting biomechanical signals during orthodontic tooth movement. Upregulation of BMAL1 expression by orthodontic force can enhance secretion of CCL2 and RANKL, ultimately promoting osteoclast recruitment. Inhibition of ERK/AP1/BMAL1 signaling can effectively reduce osteoclastic activity and slow down orthodontic tooth movement.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Jiwei Sun, Tiantian Chen, Baoying Zhao, Wenjie Fan, Yufeng Shen, Haojie Wei, Man Zhang, Wenhao Zheng, Jinfeng Peng, Jinyu Wang, Yifan Wang, Lihong Fan, Yingying Chu, Lili Chen, Cheng Yang
Summary: Oral wounds under diabetic conditions exhibit delayed healing due to oxidative stress-induced inflammation and abnormal immune responses. Additionally, the dynamic and wet oral cavity environment complicates stable treatment. To address these challenges, a biomimetic hydrogel adhesive inspired by mussels was developed. This adhesive demonstrates excellent adhesion and mechanical compatibility on oral mucosa in an acidic proinflammatory environment. It also exhibits antioxidative properties by mimicking enzymatic activities to counteract reactive oxygen species-mediated immune disorders. Experimental results on diabetic rat oral wounds showed that this hydrogel adhesive effectively protects against mucosal wounds and accelerates the inflammatory phase, thus promoting wound healing. This study offers a promising therapeutic option to improve the clinical treatment of diabetic oral wounds.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Applied
Xiaohu Zhou, Jiwei Sun, Keqi Wo, Haojie Wei, Haoqi Lei, Junyuan Zhang, Xiaofeng Lu, Feng Mei, Qingming Tang, Yifan Wang, Zhiqiang Luo, Lihong Fan, Yingying Chu, Lili Chen
Summary: This study developed a novel composite hydrogel material with excellent adaptability and supportive properties, showing remarkable efficiency in repairing facial bone defects. The use of nanoparticle-decorated porous structure can enhance communication and interaction between macrophages and stem cells, facilitating the repair process of bone defects.
CARBOHYDRATE POLYMERS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jinfeng Peng, Jiajia Zhao, Qingming Tang, Jinyu Wang, Wencheng Song, Xiaofeng Lu, Xiaofei Huang, Guangjin Chen, Wenhao Zheng, Luoying Zhang, Yunyun Han, Chunze Yan, Qian Wan, Lili Chen
Summary: Low-intensity near-infrared (NIR) light has been found to promote bone regeneration by affecting the expression and degradation of core circadian clock protein CRY1, leading to osteoblast differentiation and activation of bone formation signaling pathways.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Review
Physiology
Guangxia Feng, Jiajia Zhao, Jinfeng Peng, Beibei Luo, Jiaqi Zhang, Lili Chen, Zhi Xu
Summary: This paper provides a comprehensive review of the function of the circadian clock in oral science, discusses recent advances, highlights the importance of the circadian clock in oral tissue activity, and analyzes its role in oral health and diseases.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Jiwei Sun, Qingming Tang, Shaoling Yu, Mengru Xie, Wenhao Zheng, Guangjin Chen, Ying Yin, Xiaofei Huang, Keqi Wo, Haoqi Lei, Junyuan Zhang, Qian Wan, Lili Chen
Summary: This study reveals that F. nucleatum, a tumor-resident bacterium, accumulates in invasive margins of OSCC tissues and promotes the formation of tumor-associated macrophages (TAMs). Mechanistically, F. nucleatum triggers the GalNAc-Autophagy-TBC1D5 signaling, leading to GLUT1 aggregation in the plasma membrane and the deposition of extracellular lactate. Targeting this process may provide a distinct clinical strategy for patients with advanced OSCC.
Article
Chemistry, Multidisciplinary
Danlei Zhao, Keda Yu, Tingfang Sun, Xirui Jing, Yizhou Wan, Kaifang Chen, Hairui Gao, Yifan Wang, Lili Chen, Xiaodong Guo, Qingsong Wei
Summary: The integration of bio-adaptable performance, elaborate structure, and biological functionality is crucial for degradable bone implants. Innovations in zinc-based bone implants are achieved through material-structure-function integrated additive manufacturing (MSFI-AM), which combines in situ alloying of AM and boundary engineering strategy. These implants demonstrate mechanical self-strengthening and in situ multifunctions, such as augmenting osteogenesis and promoting bone ingrowth and regeneration through sustained release of metal cations and unique structure construction. MSFI-AMed Zn alloy implants show promising clinical translation prospects for load-bearing applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Guangjin Chen, Qingming Tang, Shaoling Yu, Yufeng Shen, Jiwei Sun, Jinfeng Peng, Ying Yin, Guangxia Feng, Xiaofeng Lu, Gang Mei, Yifan Zhang, Qian Wan, Luoying Zhang, Lili Chen
Summary: Excessive exposure to artificial light at night (LAN) can damage the formation of cartilage and impair bone growth. This is due to downregulation of the core circadian clock protein BMAL1, which leads to collagen buildup in the endoplasmic reticulum (ER). Restoring BMAL1 signaling can rescue the dysregulation of cartilage formation caused by LAN exposure, suggesting a potential therapeutic approach for promoting bone growth.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Cell Biology
Chenguang Zhang, Yuting Cai, Dang Pengrui, Jiechen Wang, Lu Wang, Jiayun Xu, Yuhan Wu, Wenwen Liu, Lili Chen, Zhengtang Luo, Feilong Deng
Summary: Developing multifunctional nanoparticles for multimodal imaging-guided combination therapy is challenging but highly desirable. In this study, graphene oxide-grafted hollow mesoporous organosilica nanoparticles loaded with doxorubicin and photosensitizers were introduced. Metal oxide nanoparticles grown on the graphene oxide surface served multiple roles in enhancing photothermal efficiency, improving magnetic resonance imaging, increasing photoacoustic imaging sensitivity and specificity, and catalyzing hydrogen peroxide for reactive oxygen species generation. The combination therapy using these nanoparticles successfully suppressed tumors without noticeable side effects, presenting a unique approach to cancer treatment.
CELL PROLIFERATION
(2023)
Article
Cell Biology
Yufeng Shen, Qingming Tang, Jiajia Wang, Zheng Zhou, Ying Yin, Yifan Zhang, Wenhao Zheng, Xinyuan Wang, Guangjin Chen, Jiwei Sun, Lili Chen
Summary: Diabetes mellitus (DM) poses a serious threat to human health and its associated bone regeneration deficiency and nonunion have a significant impact on public health. Activation of retinoic acid-related orphan receptor a (RORa) by SR1078 during early bone defect repair promotes bone regeneration in DM rats. In DM rats, RORa fails to upregulate due to IGF1-AMPK signaling deficiency induced by hyperglycemic inflammatory microenvironment. RORa is crucial for macrophage-induced migration and proliferation of bone mesenchymal stem cells (BMSCs) through CCL3/IL-6 dependent manner.
CELL PROLIFERATION
(2023)
Article
Engineering, Environmental
Zhenhua Wu, Congcan Shi, Yike Li, Aotian Chen, Lili Chen, Bin Su
Summary: This study presents the one-step construction of abrasion-resistant superhydrophilic objects with anisotropic water transport capacities using selective laser sintering. The inserted hydrophilic glass beads and thermoplastic phenol-formaldehyde resin grains form long capillary channels, enabling anisotropic water transport on different surfaces. The superhydrophilic materials also exhibit abrasion resistance and excellent anti-gravity water transport ability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Qian Liu, Irene Lodoso-Torrecilla, Raquel Klein Gunnewiek, Harry R. Harhangi, Antonios G. Mikos, Laura van Niftrik, John A. Jansen, Lili Chen, Jeroen J. J. P. van den Beucken
Summary: In this study, a system was established to achieve different release profiles of the antibiotic drug doxycycline from calcium phosphate cements (CPCs) by adjusting the formulation. The CPC formulations showed appropriate handling properties and released doxycycline with antibacterial activity against Staphylococcus aureus. In vivo implantation experiments demonstrated the effectiveness of the CPC system in local antibacterial therapy.
Review
Biochemistry & Molecular Biology
Xiaofei Huang, Mengru Xie, Xiaofeng Lu, Feng Mei, Wencheng Song, Yang Liu, Lili Chen
Summary: Atherosclerosis is an inflammatory vascular disease that leads to cardiovascular diseases and stroke. Infection, such as periodontitis, has been implicated as a contributing risk factor for atherosclerosis. This review summarizes the prevalent periodontal pathogens found in atherosclerotic plaques, their association with atherosclerosis-related diseases, and the mechanisms by which these pathogens contribute to the progression and destabilization of plaques. Understanding the relationship between periodontal pathogens and atherosclerosis will provide valuable insights and potential therapeutic approaches for its prevention and management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Materials Science, Multidisciplinary
Xian Cheng, Yanping Liu, Ousheng Liu, Yanqin Lu, Zhengwei Liao, Zoya Hadzhieva, Lili Chen, Sander G. C. Leeuwenburgh, Aldo R. Boccaccini, Fang Yang
Summary: Electrophoretic deposition (EPD) is an effective technique for constructing coatings on medical devices, which can be used for local delivery of therapeutic agents. This manuscript provides a comprehensive overview of EPD coatings for drug delivery, with a focus on the mechanism and control over loading and release of therapeutic agents. The different strategies for loading therapeutic agents and factors influencing loading are discussed, as well as the release mechanisms and techniques used to control release kinetics. The applications of therapeutic agent loaded EPD coatings are summarized, and the remaining challenges and future perspectives are reviewed.
PROGRESS IN MATERIALS SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Xinyuan Wang, Qian Liu, Jinfeng Peng, Wencheng Song, Jiajia Zhao, Lili Chen
Summary: Malocclusion, a major disease, affects 56% of oral and systemic health globally. Orthodontics is the primary method, but complications associated with long-term therapy exist. Photobiomodulation (PBM) therapy can shorten orthodontic treatment duration by 26% to 40%. This review evaluates the efficacy, mechanisms, clinical trials, and future developments of PBM therapy in orthodontics, providing evidence-based support for the research and development of light-related orthodontic tooth movement acceleration devices.
