Crosstalk network among multiple inflammatory mediators in liver fibrosis

Ly6C+ Monocytes and Kupffer Cells Orchestrate Liver Immune Responses Against Hepatitis B Virus in Mice

(2019) Li-Ling Wu et al.   HEPATOLOGY

Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis

(2019) Leah M. Norona et al.   PLoS One

The influence of the rs1137101 genotypes of leptin receptor gene on the demographic and metabolic profile of normal Saudi females and those suffering from polycystic ovarian syndrome

(2019) Maha H. Daghestani et al.   BMC Womens Health

Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signaling

(2019) Jun Li et al.   EBioMedicine

Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt/β-catenin pathway

(2019) Xiaoli Rong et al.   Stem Cell Research & Therapy

MicroRNA-101 suppresses liver fibrosis by downregulating PI3K/Akt/mTOR signaling pathway

(2019) Yang Lei et al.   Clinics and Research in Hepatology and Gastroenterology

The clinical significance of intrahepatic Th22 cells in liver cirrhosis

(2019) Shanyu Qin et al.   Advances in Clinical and Experimental Medicine

Diffusion-weighted magnetic resonance imaging and micro-RNA in the diagnosis of hepatic fibrosis in chronic hepatitis C virus

(2019) Tarek Besheer et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Activated NK cells kill hepatic stellate cells via p38/PI3K signaling in a TRAIL‐involved degranulation manner

(2019) Tianyang Li et al.   JOURNAL OF LEUKOCYTE BIOLOGY

rSJYB1 inhibits collagen type I protein expression in hepatic stellate cells via down‐regulating activity of collagen α1 (I) promoter

(2019) Liuting Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Interleukin-1 Receptor Antagonist Modulates Liver Inflammation and Fibrosis in Mice in a Model-Dependent Manner

(2019) Raphael Meier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Deleterious Impact of Interleukin 9 to Hepatorenal Physiology

(2019) Nadjania Saraiva de Lira Silva et al.   INFLAMMATION

Neutrophil-to-lymphocyte ratio is independently associated with inflammatory activity and fibrosis grade in nonalcoholic fatty liver disease

(2019) Tawfik Khoury et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Adoptive transfer of regulatory T cells stimulated by Allogeneic Hepatic Stellate Cells mitigates liver injury in mice with concanavalin A-induced autoimmune hepatitis

(2019) Huifang Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A novel STAT3 inhibitor, STX-0119, attenuates liver fibrosis by inactivating hepatic stellate cells in mice

(2019) Seungho Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The anti-fibrotic role of mast cells in the liver is mediated by HLA-G and interaction with hepatic stellate cells

(2019) Laurence Amiot et al.   CYTOKINE

miR‐193a/b‐3p relieves hepatic fibrosis and restrains proliferation and activation of hepatic stellate cells

(2019) Baoling Ju et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MicroRNA-26b-5p Inhibits Mouse Liver Fibrogenesis and Angiogenesis by Targeting PDGF Receptor-Beta

(2019) Le Yang et al.   Molecular Therapy-Nucleic Acids

Loss of toll-like receptor 3 aggravates hepatic inflammation but ameliorates steatosis in mice

(2018) Young-Sun Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CXCL10-induced IL-9 promotes liver fibrosis via Raf/MEK/ERK signaling pathway

(2018) Xiaoyun Guo et al.   BIOMEDICINE & PHARMACOTHERAPY

MicroRNA-34a-5p inhibits liver fibrosis by regulating TGF-β1/Smad3 pathway in hepatic stellate cells

(2018) Xiaofei Li et al.   CELL BIOLOGY INTERNATIONAL

Effect of soothing Gan (Liver) and invigorating Pi (Spleen) recipes on TLR4-p38 MAPK pathway in kupffer cells of non-alcoholic steatohepatitis rats

(2018) Xiang-wen Gong et al.   Chinese Journal of Integrative Medicine

Expression of Fibroblast Growth Factor 21 and β-Klotho Regulates Hepatic Fibrosis through the Nuclear Factor-κB and c-Jun N-Terminal Kinase Pathways

(2018) Kyong Joo Lee et al.   Gut and Liver

Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2

(2018) Tian Lan et al.   HEPATOLOGY

Kupffer-derived matrix metalloproteinase-9 contributes to liver fibrosis resolution

(2018) Min Feng et al.   International Journal of Biological Sciences

TLR2 Stimulation Strengthens Intrahepatic Myeloid-Derived Cell-Mediated T Cell Tolerance through Inducing Kupffer Cell Expansion and IL-10 Production

(2018) Jia Liu et al.   JOURNAL OF IMMUNOLOGY

An efficient method to isolate Kupffer cells eliminating endothelial cell contamination and selective bias

(2018) Ruairi W. Lynch et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-22 inactivates hepatic stellate cells via downregulation of the TGF-β1/Notch signaling pathway

(2018) Enran Chen et al.   Molecular Medicine Reports

IL-34 Inhibits Acute Rejection of Rat Liver Transplantation by Inducing Kupffer Cell M2 Polarization

(2018) Zhengfei Zhao et al.   TRANSPLANTATION

Serum interleukin-34 level can be an indicator of liver fibrosis in patients with chronic hepatitis B virus infection

(2018) Yin-Qiu Wang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Hepatoprotective effects of ethyl pyruvate against CCl4-induced hepatic fibrosis via inhibition of TLR4/NF-κB signaling and up-regulation of MMPs/TIMPs ratio

(2018) Mingxiao Zhang et al.   Clinics and Research in Hepatology and Gastroenterology

Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways

(2018) Jiao Feng et al.   Drug Design Development and Therapy

Interleukin (IL)-13, Prostaglandin E2 (PGE2), and Prostacyclin 2 (PGI2) Activate Hepatic Stellate Cells via Protein kinase C (PKC) Pathway in Hepatic Fibrosis

(2018) Guode Sui et al.   MEDICAL SCIENCE MONITOR

Soluble fibrinogen-like protein 2 ameliorates acute rejection of liver transplantation in rat via inducing Kupffer cells M2 polarization

(2018) Guangrui Pan et al.   Cancer Medicine

Unique Action of Interleukin-18 on T Cells and Other Immune Cells

(2018) Kenji Nakanishi   Frontiers in Immunology

Spermine Alleviates Acute Liver Injury by Inhibiting Liver-Resident Macrophage Pro-Inflammatory Response Through ATG5-Dependent Autophagy

(2018) Shun Zhou et al.   Frontiers in Immunology

The association of single nucleotide polymorphisms of Toll-like receptor 3, Toll-like receptor 7 and Toll-like receptor 8 genes with the susceptibility to HCV infection

(2018) M El-Bendary et al.   BRITISH JOURNAL OF BIOMEDICAL SCIENCE

Pharmacological inhibition of CCR2/5 signaling prevents and reverses alcohol-induced liver damage, steatosis and inflammation in mice

(2018) Aditya Ambade et al.   HEPATOLOGY

CXCL6-EGFR-induced Kupffer cells secrete TGF-β1 promoting hepatic stellate cell activation via the SMAD2/BRD4/C-MYC/EZH2 pathway in liver fibrosis

(2018) Xiaobo Cai et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis

(2018) Shimaa Farouk et al.   PLoS One

Interleukin-35 Attenuates D-Galactosamine/Lipopolysaccharide-Induced Liver Injury via Enhancing Interleukin-10 Production in Kupffer Cells

(2018) Xing-Feng Zheng et al.   Frontiers in Pharmacology

Increased interleukin-23 receptor (IL-23R) expression is associated with disease severity in acute-on-chronic liver failure

(2018) Arshi Khanam et al.   LIVER INTERNATIONAL

MicroRNA‑219 overexpression serves a protective role during liver fibrosis by targeting tumor growth factor β receptor 2

(2018) Li Ma et al.   Molecular Medicine Reports

RAMP1 in Kupffer cells is a critical regulator in immune-mediated hepatitis

(2018) Tomoyoshi Inoue et al.   PLoS One

Luteolin Targets the Toll-Like Receptor Signaling Pathway in Prevention of Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice

(2018) Eun-Young Kwon et al.   Nutrients

The Role of Monocytes and Macrophages in Acute and Acute-on-Chronic Liver Failure

(2018) Evangelos Triantafyllou et al.   Frontiers in Immunology

MicroRNA 181b-3p and its target importin α5 regulate toll-like receptor 4 signaling in Kupffer cells and liver injury in mice in response to ethanol

(2017) Paramananda Saikia et al.   HEPATOLOGY

γδT cells are indispensable for interleukin-23-mediated protection against Concanavalin A-induced hepatitis in hepatitis B virus transgenic mice

(2017) Ziyu Meng et al.   IMMUNOLOGY

Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway

(2017) Liu-Ya Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury

(2017) Lara Campana et al.   JOURNAL OF IMMUNOLOGY

MiR-142-3p blocks TGF-β-induced activation of hepatic stellate cells through targeting TGFβRI

(2017) Xiaoxue Yang et al.   LIFE SCIENCES

Genetic variations in toll-like receptors 7 and 8 modulate natural hepatitis C outcomes and liver disease progression

(2017) Fatima-Zohra Fakhir et al.   LIVER INTERNATIONAL

Curcumin Promotes Apoptosis of Activated Hepatic Stellate Cells by Inhibiting Protein Expression of the MyD88 Pathway

(2017) Ya-Jun He et al.   PLANTA MEDICA

Both MAPK and STAT3 signal transduction pathways are necessary for IL-6-dependent hepatic stellate cells activation

(2017) Polina Kagan et al.   PLoS One

Antioxidant axis Nrf2-keap1-ARE in inhibition of alcoholic liver fibrosis by IL-22

(2017) Ya-Hui Ni et al.   WORLD JOURNAL OF GASTROENTEROLOGY

MiR-130a-3p attenuates activation and induces apoptosis of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2

(2017) Yang Wang et al.   Cell Death & Disease

Role of interleukin-23 in monocyte-derived dendritic cells of HBV-related acute-on-chronic liver failure and its correlation with the severity of liver damage

(2017) Suxia Bao et al.   Clinics and Research in Hepatology and Gastroenterology

Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emperipolesis in HBV cirrhotic patients

(2017) Jijing Shi et al.   Scientific Reports

miR-200c Accelerates Hepatic Stellate Cell-Induced Liver Fibrosis via Targeting the FOG2/PI3K Pathway

(2017) Tengfei Ma et al.   Biomed Research International

Anti-fibrotic Effects of Synthetic Oligodeoxynucleotide for TGF-β1 and Smad in an Animal Model of Liver Cirrhosis

(2017) Jung-Yeon Kim et al.   Molecular Therapy-Nucleic Acids

MircoRNA-145 promotes activation of hepatic stellate cells via targeting krüppel-like factor 4

(2017) Ruoting Men et al.   Scientific Reports

TGF-β-induced hepatocyte lincRNA-p21 contributes to liver fibrosis in mice

(2017) Xiaolong Tu et al.   Scientific Reports

Role of TGF-β signaling in differentiation of mesothelial cells to vitamin A-poor hepatic stellate cells in liver fibrosis

(2016) Yuchang Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Suppressive effect of microRNA-29b on hepatic stellate cell activation and its crosstalk with TGF-β1/Smad3

(2016) Chunli Liang et al.   CELL BIOCHEMISTRY AND FUNCTION

CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in HBsAg transgenic mice by promoting the interaction of NKT cells with Kupffer cells

(2016) Xin Hou et al.   Cellular & Molecular Immunology

IL-10-producing regulatory B-cells suppressed effector T-cells but enhanced regulatory T-cells in chronic HBV infection

(2016) Y. Liu et al.   CLINICAL SCIENCE

Pharmacokinetics, Safety, and CCR2/CCR5 Antagonist Activity of Cenicriviroc in Participants With Mild or Moderate Hepatic Impairment

(2016) E Lefebvre et al.   CTS-Clinical and Translational Science

Mechanism of Corilagin interference with IL-13/STAT6 signaling pathways in hepatic alternative activation macrophages in schistosomiasis-induced liver fibrosis in mouse model

(2016) Peng Du et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Isorhamnetin attenuates liver fibrosis by inhibiting TGF-β/Smad signaling and relieving oxidative stress

(2016) Ji Hye Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Exosome-mediated activation of toll-like receptor 3 in stellate cells stimulates interleukin-17 production by γδ T cells in liver fibrosis

(2016) Wonhyo Seo et al.   HEPATOLOGY

Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells

(2016) Yumin Oh et al.   HEPATOLOGY

Epidermal growth factor signaling protects from cholestatic liver injury and fibrosis

(2016) Jasmin Svinka et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Plasma Cytokeratin-18 Level As a Novel Biomarker for Liver Fibrosis in Children With Nonalcoholic Fatty Liver Disease

(2016) Chetan Mandelia et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Involvement of TGF-β1/Smad3 Signaling in Carbon Tetrachloride-Induced Acute Liver Injury in Mice

(2016) Liman Niu et al.   PLoS One

ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis

(2016) Shirley Oren Ben-Shoshan et al.   RNA Biology

Antagonism of Interleukin-17A ameliorates experimental hepatic fibrosis by restoring the IL-10/STAT3-suppressed autophagy in hepatocytes

(2016) Xiao-Wei Zhang et al.   Oncotarget

Interleukin-22 ameliorates liver fibrosis through miR-200a/beta-catenin

(2016) Bang-li Hu et al.   Scientific Reports

Interleukin-34 as a fibroblast-derived marker of liver fibrosis in patients with non-alcoholic fatty liver disease

(2016) Hirotaka Shoji et al.   Scientific Reports

New Insight into the Anti-liver Fibrosis Effect of Multitargeted Tyrosine Kinase Inhibitors: From Molecular Target to Clinical Trials

(2016) Kai Qu et al.   Frontiers in Pharmacology

TLR2 and TLR9 contribute to alcohol-mediated liver injury through induction of CXCL1 and neutrophil infiltration

(2015) Yoon Seok Roh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Up-regulation of interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C

(2015) Li-Yuan Wu et al.   CLINICAL IMMUNOLOGY

Regulatory CD4+ T cells modulate the interaction between NK cells and hepatic stellate cells by acting on either cell type

(2015) Bettina Langhans et al.   JOURNAL OF HEPATOLOGY

24-nor-ursodeoxycholic acid ameliorates inflammatory response and liver fibrosis in a murine model of hepatic schistosomiasis

(2015) Martina Sombetzki et al.   JOURNAL OF HEPATOLOGY

Kupffer Cells Support Hepatitis B Virus–Mediated CD8+T Cell Exhaustion via Hepatitis B Core Antigen–TLR2 Interactions in Mice

(2015) Min Li et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-17-5p activates hepatic stellate cells through targeting of Smad7

(2015) Fujun Yu et al.   LABORATORY INVESTIGATION

Interleukin-22 ameliorates liver fibrogenesis by attenuating hepatic stellate cell activation and downregulating the levels of inflammatory cytokines

(2015) Dong-Hong Lu   WORLD JOURNAL OF GASTROENTEROLOGY

MicroRNA-17-5p-activated Wnt/β-catenin pathway contributes to the progression of liver fibrosis

(2015) Fujun Yu et al.   Oncotarget

microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway

(2015) Jia Wang et al.   Oncotarget

Sauchinone attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway

(2014) Ju-Hee Lee et al.   CHEMICO-BIOLOGICAL INTERACTIONS

CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis

(2014) Josef Ehling et al.   GUT

IL-34 and macrophage colony-stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen synthesis by hepatic stellate cells

(2014) Laurence Preisser et al.   HEPATOLOGY

IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice

(2014) Abhisek Mitra et al.   HEPATOLOGY

Can Toll-Like Receptor (TLR) 2 be considered as a new target for immunotherapy against hepatitis B infection?

(2014) Vahid Bagheri et al.   HUMAN IMMUNOLOGY

IL-17A Enhances the Expression of Profibrotic Genes through Upregulation of the TGF-β Receptor on Hepatic Stellate Cells in a JNK-Dependent Manner

(2014) Thomas Fabre et al.   JOURNAL OF IMMUNOLOGY

Wnt signaling in liver fibrosis: Progress, challenges and potential directions

(2013) Cheng-gui Miao et al.   BIOCHIMIE

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Toll-like receptor 7-mediated type I interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis

(2013) Yoon Seok Roh et al.   HEPATOLOGY

Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment

(2013) Juanjuan Zhao et al.   HEPATOLOGY

Transforming Growth Factor-β (TGF-β)-mediated Connective Tissue Growth Factor (CTGF) Expression in Hepatic Stellate Cells Requires Stat3 Signaling Activation

(2013) Yan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pro-Inflammatory Activated Kupffer Cells by Lipids Induce Hepatic NKT Cells Deficiency through Activation-Induced Cell Death

(2013) Tongfang Tang et al.   PLoS One

Preproendothelin-1 expression is negatively regulated by IFNγ during hepatic stellate cell activation

(2012) Tianxia Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Huangqi decoction inhibits apoptosis and fibrosis, but promotes Kupffer cell activation in dimethylnitrosamine-induced rat liver fibrosis

(2012) Cheng Liu et al.   BMC Complementary and Alternative Medicine

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

(2012) Fanli Meng et al.   GASTROENTEROLOGY

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

(2012) Xiaoni Kong et al.   HEPATOLOGY

Th2-Associated Alternative Kupffer Cell Activation Promotes Liver Fibrosis without Inducing Local Inflammation

(2012) Giuliana López-Navarrete et al.   International Journal of Biological Sciences

Asiatic Acid Inhibits Liver Fibrosis by Blocking TGF-beta/Smad Signaling In Vivo and In Vitro

(2012) Li-xia Tang et al.   PLoS One

Inflammation-associated interleukin-6/signal transducer and activator of transcription 3 activation ameliorates alcoholic and nonalcoholic fatty liver diseases in interleukin-10-deficient mice

(2011) Andrew M. Miller et al.   HEPATOLOGY

Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice

(2011) Yehuda Kamari et al.   JOURNAL OF HEPATOLOGY

CCL5 mRNA is a marker for early fibrosis in chronic hepatitis C and is regulated by interferon-α therapy and toll-like receptor 3 signalling

(2011) A. Katsounas et al.   JOURNAL OF VIRAL HEPATITIS

Interleukin-8 Is Activated in Patients with Chronic Liver Diseases and Associated with Hepatic Macrophage Accumulation in Human Liver Fibrosis

(2011) Henning W. Zimmermann et al.   PLoS One

Epigenetic regulation in alcoholic liver disease

(2011) Pranoti Mandrekar   WORLD JOURNAL OF GASTROENTEROLOGY

CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation

(2010) Edith Hintermann et al.   JOURNAL OF AUTOIMMUNITY

Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

(2010) W. R. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS