Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators

(2018) Julian Nüchel et al.   Autophagy

Transcriptional network systems in cartilage development and disease

(2018) Riko Nishimura et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis

(2018) Eleni Zengini et al.   NATURE GENETICS

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

A Multicenter, Double-Blind, Phase III Clinical Trial to Evaluate the Efficacy and Safety of a Cell and Gene Therapy in Knee Osteoarthritis Patients

(2018) Myung-Ku Kim et al.   Human Gene Therapy Clinical Development

Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis

(2017) Julia Steinberg et al.   Scientific Reports

Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations

(2017) Bram P. Prins et al.   Scientific Reports

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

(2016) Jie Zheng et al.   BIOINFORMATICS

A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn’s Disease and Human Gut Microbiome Composition

(2016) Dalin Li et al.   GASTROENTEROLOGY

A blood pressure-associated variant of theSLC39A8gene influences cellular cadmium accumulation and toxicity

(2016) Ruoxin Zhang et al.   HUMAN MOLECULAR GENETICS

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Open Targets: a platform for therapeutic target identification and validation

(2016) Gautier Koscielny et al.   NUCLEIC ACIDS RESEARCH

Genetic Determinism of Primary Early-Onset Osteoarthritis

(2016) Juliette Aury-Landas et al.   TRENDS IN MOLECULAR MEDICINE

The Genotype-Tissue Expression (GTEx) Project

(2015) Latarsha J. Carithers et al.   BIOPRESERVATION AND BIOBANKING

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments

(2015) C.-H. Chou et al.   OSTEOARTHRITIS AND CARTILAGE

The Genotype-Tissue Expression (GTEx) Project

(2015) Latarsha J. Carithers et al.   Biopreservation and Biobanking

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Regulation of the Catabolic Cascade in Osteoarthritis by the Zinc-ZIP8-MTF1 Axis

(2014) Jin-Hong Kim et al.   CELL

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

MicroRNA-146a Regulates Human Foetal Femur Derived Skeletal Stem Cell Differentiation by Down-Regulating SMAD2 and SMAD3

(2014) Kelvin S. C. Cheung et al.   PLoS One

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

(2013) Evangelos Evangelou et al.   ANNALS OF THE RHEUMATIC DISEASES

Health economics in the field of osteoarthritis: An Expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)

(2013) Mickaël Hiligsmann et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

NFAT3 and TGF-β/SMAD3 regulate the expression of miR-140 in osteoarthritis

(2013) Ginette Tardif et al.   ARTHRITIS RESEARCH & THERAPY

The effect of surgical factors on early patient-reported outcome measures (PROMS) following total knee replacement

(2012) P. N. Baker et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study

(2012)   LANCET

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Theo Vos et al.   LANCET

Evaluating the effective numbers of independent tests and significant p-value thresholds in commercial genotyping arrays and public imputation reference datasets

(2011) Miao-Xin Li et al.   HUMAN GENETICS

TGF-β regulates β-catenin signaling and osteoblast differentiation in human mesenchymal stem cells

(2011) Shuanhu Zhou   JOURNAL OF CELLULAR BIOCHEMISTRY

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

(2010) Matthew B. Lanktree et al.   AMERICAN JOURNAL OF HUMAN GENETICS

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study

(2010) K. Panoutsopoulou et al.   ANNALS OF THE RHEUMATIC DISEASES

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Latent TGF-β binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells

(2008) Katri Koli et al.   BONE

Bayes factors for genome-wide association studies: comparison withP-values

(2008) Jon Wakefield   GENETIC EPIDEMIOLOGY