Islets from human donors with higher but not lower hemoglobin A1c levels respond to gastrin treatment in vitro

Oxygen environment and islet size are the primary limiting factors of isolated pancreatic islet survival

(2017) Hirotake Komatsu et al.   PLoS One

Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes

(2017) A. S. Axelsson et al.   Nature Communications

Evidence for Loss in Identity, De-Differentiation, and Trans-Differentiation of Islet β-Cells in Type 2 Diabetes

(2017) Chad S. Hunter et al.   Frontiers in Genetics

Isolated human islets require hyperoxia to maintain islet mass, metabolism, and function

(2016) Hirotake Komatsu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas

(2016) Yue J. Wang et al.   Cell Metabolism

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes

(2016) Tehila Dahan et al.   DIABETES

Pancreatic β cell identity requires continual repression of non–β cell programs

(2016) Giselle Domínguez Gutiérrez et al.   JOURNAL OF CLINICAL INVESTIGATION

A Single-Cell Transcriptome Atlas of the Human Pancreas

(2016) Mauro J. Muraro et al.   Cell Systems

Therapy with proton pump inhibitors in patients with type 2 diabetes is independently associated with improved glycometabolic control

(2015) Ilaria Barchetta et al.   ACTA DIABETOLOGICA

The Effect of Proton Pump Inhibitors on Glycated Hemoglobin Levels in Patients With Type 2 Diabetes Mellitus

(2015) Na Han et al.   Canadian Journal of Diabetes

Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing  -cells to a  -like fate and reveals a facultative proliferative capacity in aged  -cells

(2015) F. C. Pan et al.   DEVELOPMENT

Loss of β-Cell Identity Occurs in Type 2 Diabetes and Is Associated With Islet Amyloid Deposits

(2015) H. Siebe Spijker et al.   DIABETES

Effect of pantoprazole on insulin secretion in drug-naïve patients with type 2 diabetes

(2015) Manuel González-Ortiz et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Pax4 acts as a key player in pancreas development and plasticity

(2015) Tiziana Napolitano et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

(2014) Tao Gao et al.   Cell Metabolism

MafA is critical for maintenance of the mature beta cell phenotype in mice

(2014) Wataru Nishimura et al.   DIABETOLOGIA

The diabetes gene Hhex maintains  -cell differentiation and islet function

(2014) J. Zhang et al.   GENES & DEVELOPMENT

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

(2014) Barak Blum et al.   eLife

Expression of Mesenchymal and  -Cell Phenotypic Markers in Islet  -Cells in Recently Diagnosed Diabetes

(2013) M. G. White et al.   DIABETES CARE

Inactivation of specific β cell transcription factors in type 2 diabetes

(2013) Shuangli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

(2013) Brandon L. Taylor et al.   Cell Reports

Effects of 12 weeks’ treatment with a proton pump inhibitor on insulin secretion, glucose metabolism and markers of cardiovascular risk in patients with type 2 diabetes: a randomised double-blind prospective placebo-controlled study

(2012) K. D. Hove et al.   DIABETOLOGIA

Pantoprazole Improves Glycemic Control in Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial

(2012) Pawan Kumar Singh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adverse Effects of Long-Term Proton Pump Inhibitor Therapy

(2011) Edward Sheen et al.   DIGESTIVE DISEASES AND SCIENCES

Gastrin Treatment Stimulates β-Cell Regeneration and Improves Glucose Tolerance in 95% Pancreatectomized Rats

(2011) Noèlia Téllez et al.   ENDOCRINOLOGY

Treatment with a proton pump inhibitor improves glycaemic control in Psammomys obesus, a model of type 2 diabetes

(2010) T. B. Bödvarsdóttir et al.   DIABETOLOGIA

Cholecystokinin Is Up-Regulated in Obese Mouse Islets and Expands β-Cell Mass by Increasing β-Cell Survival

(2010) Jeremy A. Lavine et al.   ENDOCRINOLOGY

Combination Therapy with Glucagon-Like Peptide-1 and Gastrin Induces β-Cell Neogenesis from Pancreatic Duct Cells in Human Islets Transplanted in Immunodeficient Diabetic Mice

(2008) Wilma L. Suarez-Pinzon et al.   CELL TRANSPLANTATION

In Vitro Proliferation of Cells Derived From Adult Human  -Cells Revealed By Cell-Lineage Tracing

(2008) H. A. Russ et al.   DIABETES

Insights into the binding and activation sites of the receptors for cholecystokinin and gastrin

(2007) Magali Foucaud et al.   REGULATORY PEPTIDES